Trauma

The need for an artificial oxygen carrier for disasters and pandemics, including COVID‐19

https://onlinelibrary.wiley.com/doi/10.1111/trf.16122

Freeze-dried plasma mitigates the dilution effects of a hemoglobin-based oxygen carrier (HBOC-201) in a model of resuscitation for hemorrhage and hemodilution

https://www.ncbi.nlm.nih.gov/pubmed/31246911

Selective aortic arch perfusion with fresh whole blood or HBOC-201 reverses hemorrhage-induced traumatic cardiac arrest in a lethal model of noncompressible torso hemorrhage

https://www.ncbi.nlm.nih.gov/pubmed/31211744

Reassessment of the need for an oxygen carrier for the treatment of traumatic hemorrhage when blood is not an option

https://pubmed.ncbi.nlm.nih.gov/31348149/

Use of hemoglobin based oxygen carrier HBOC-021 (Hemopure) as a bridge during emergencies in patients unable to receive blood products: experience at a tertiary care center

https://ashpublications.org/blood/article/130/Supplement%201/4926/80958/Use-of-Hemoglobin-Based-Oxygen-Carrier-HBOC-021

Hypertonic HBOC-201 decreases neutrophil activation after hemorrhagic shock

https://www.ncbi.nlm.nih.gov/pubmed/24456255

Resuscitation from hemorrhagic shock using polymerized hemoglobin compared to blood

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049234/

Experience with the use of Hemopure in the care of a massively burned adult

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945828/

Traumatic brain injury and severe uncontrolled haemorrhage with short delay pre-hospital resuscitation in a swine model.

https://www.ncbi.nlm.nih.gov/pubmed/21036354

New and future resuscitation fluids for trauma patients using hemoglobin and hypertonic saline

https://www.ncbi.nlm.nih.gov/pubmed/23351531

The effect HBOC-201 and sodium nitrite resuscitation after uncontrolled haemorrhagic shock in swine

https://www.ncbi.nlm.nih.gov/pubmed/21094491

Pre-hospital resuscitation with HBOC-201 and rFVIIa compared to HBOC-201 alone in uncontrolled hemorrhagic shock in swine

https://www.ncbi.nlm.nih.gov/pubmed/21806503

A synthetic haemoglobin-based oxygen carrier and the reversal of cardiac hypoxia secondary to severe anaemia following trauma

https://www.ncbi.nlm.nih.gov/pubmed/21534906

Vasoactive hemoglobin solution improves survival in hemodilution followed by hemorrhagic shock

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3318980/

Is there a role for hemopure in the prehospital setting?

https://www.ncbi.nlm.nih.gov/pubmed/21841569

A bovine hemoglobin-based oxygen carrier as pump prime for cardiopulmonary bypass: reduced systemic lactic acidosis and improved cerebral oxygen metabolism during low flow in a porcine model

https://www.ncbi.nlm.nih.gov/pubmed/21641005

Amylase and lipase detection in hemorrhaged animals treated with HBOC-201

https://www.ncbi.nlm.nih.gov/pubmed/21171938

Hemoglobin-based oxygen carrier (HBOC-201) and escalating doses of recombinant factor VIIa (rFVIIa) as a novel pre-hospital resuscitation fluid in a swine model of severe uncontrolled hemorrhage

https://www.ncbi.nlm.nih.gov/pubmed/20645681

Nitroglycerin attenuates vasoconstriction of HBOC-201 during hemorrhagic shock resuscitation

https://www.ncbi.nlm.nih.gov/pubmed/20080328

Resuscitation with the hemoglobin-based oxygen carrier, HBOC-201, in a swine model of severe uncontrolled hemorrhage and traumatic brain injury

https://www.ncbi.nlm.nih.gov/pubmed/18497706

Innate immune response after resuscitation with hemoglobin-based oxygen carrier and recombinant factor VIIA in uncontrolled hemorrhagic shock in a swine model

https://www.ncbi.nlm.nih.gov/pubmed/18545114

Management of hemorrhagic shock when blood is not an option

https://www.ncbi.nlm.nih.gov/pubmed/19019664

Use of hemoglobin-based oxygen-carrying solution-201 to improve resuscitation parameters and prevent secondary brain injury in a swine model of traumatic brain injury and hemorrhage: laboratory investigation

https://www.ncbi.nlm.nih.gov/pubmed/18312106

Hemoglobin-based oxygen carrying compound-201 as salvage therapy for severe neuro- and polytrauma (Injury Severity Score = 27-41

https://www.ncbi.nlm.nih.gov/pubmed/18766094

Hematologic effects of recombinant factor VIIa combined with hemoglobin-based oxygen carrier-201 for prehospital resuscitation of swine with severe uncontrolled hemorrhage due to liver injury

https://www.ncbi.nlm.nih.gov/pubmed/18832908

Innate immune responses in Swine resuscitated from severe traumatic hemorrhagic shock with hemoglobin-based oxygen carrier-201

https://www.ncbi.nlm.nih.gov/pubmed/17573626

Hematology patterns after hemoglobin-based oxygen carrier resuscitation from severe controlled hemorrhage with prolonged delayed definitive care

https://www.ncbi.nlm.nih.gov/pubmed/17958540

Immune effects of decreasing low-molecular weight hemoglobin components of hemoglobin-based oxygen carriers (HBOC) in a swine model of severe controlled hemorrhagic shock

https://www.ncbi.nlm.nih.gov/pubmed/17922315

Resuscitation following severe, controlled hemorrhage associated with a 24 h delay to surgical intervention in swine using a hemoglobin based oxygen carrier as an oxygen bridge to definitive care

https://www.ncbi.nlm.nih.gov/pubmed/17383073

Resuscitation from hemorrhagic shock comparing standard hemoglobin-based oxygen carrier (HBOC)-201 versus 7.5% hypertonic HBOC-201

https://www.ncbi.nlm.nih.gov/pubmed/17993959

Resuscitation from hemorrhagic shock with HBOC-201 in the setting of traumatic brain injury

https://www.ncbi.nlm.nih.gov/pubmed/17505305

Coagulation patterns following haemoglobin-based oxygen carrier resuscitation in severe uncontrolled haemorrhagic shock in swine

https://www.ncbi.nlm.nih.gov/pubmed/16879158

Systemic function, oxygenation and microvascular correlation during treatment of hemorrhagic shock with blood substitutes

https://www.ncbi.nlm.nih.gov/pubmed/16543653

Bovine polymerized hemoglobin (hemoglobin-based oxygen carrier-201) resuscitation in three swine models of hemorrhagic shock with militarily relevant delayed evacuation--effects on histopathology and organ function

https://www.ncbi.nlm.nih.gov/pubmed/16540964

Bovine polymerized hemoglobin versus Hextend resuscitation in a swine model of severe controlled hemorrhagic shock with delay to definitive care

https://www.ncbi.nlm.nih.gov/pubmed/16912657

Prehospital HBOC-201 after traumatic brain injury and hemorrhagic shock in swine

https://www.ncbi.nlm.nih.gov/pubmed/16832248

Immune effects of resuscitation with HBOC-201, a hemoglobin-based oxygen carrier, in swine with moderately severe hemorrhagic shock from controlled hemorrhage

https://www.ncbi.nlm.nih.gov/pubmed/16369186

A hemoglobin-based oxygen carrier, bovine polymerized hemoglobin (HBOC-201) versus hetastarch (HEX) in a moderate severity hemorrhagic shock swine model with delayed evacuation

https://www.ncbi.nlm.nih.gov/pubmed/16081200

Resuscitation with a hemoglobin-based oxygen carrier after traumatic brain injury

https://www.ncbi.nlm.nih.gov/pubmed/16361895

Effects of bovine polymerized hemoglobin on coagulation in controlled hemorrhagic shock in swine

https://www.ncbi.nlm.nih.gov/pubmed/16044085

Prolonged low-volume resuscitation with HBOC-201 in a large-animal survival model of controlled hemorrhage

https://www.ncbi.nlm.nih.gov/pubmed/16294065

Resuscitation with a blood substitute causes vasoconstriction without nitric oxide scavenging in a model of arterial hemorrhage

https://www.ncbi.nlm.nih.gov/pubmed/15501108

A hemoglobin based oxygen carrier, bovine polymerized hemoglobin (HBOC-201) versus Hetastarch (HEX) in an uncontrolled liver injury hemorrhagic shock swine model with delayed evacuation

https://www.ncbi.nlm.nih.gov/pubmed/15514525

Low-volume resuscitation with a polymerized bovine hemoglobin-based oxygen-carrying solution (HBOC-201) provides adequate tissue oxygenation for survival in a porcine model of controlled hemorrhage

https://www.ncbi.nlm.nih.gov/pubmed/14608160

A comparison of the hemoglobin-based oxygen carrier HBOC-201 to other low-volume resuscitation fluids in a model of controlled hemorrhagic shock

https://www.ncbi.nlm.nih.gov/pubmed/14566133

Small-volume resuscitation with the hemoglobin substitute HBOC-201: effect on brain tissue oxygenation

https://www.ncbi.nlm.nih.gov/pubmed/14562727

Tissue oxygen monitoring during hemorrhagic shock and resuscitation: a comparison of lactated Ringer's solution, hypertonic saline dextran, and HBOC-201

https://www.ncbi.nlm.nih.gov/pubmed/12579047

HBOC-201 improves survival in a swine model of hemorrhagic shock and liver injury

https://www.ncbi.nlm.nih.gov/pubmed/12104112

Small-volume resuscitation with HBOC-201: effects on cardiovascular parameters and brain tissue oxygen tension in an out-of-hospital model of hemorrhage in swine

https://www.ncbi.nlm.nih.gov/pubmed/12359531

Selective aortic arch perfusion with hemoglobin-based oxygen carrier-201 for resuscitation from exsanguinating cardiac arrest in swine

https://www.ncbi.nlm.nih.gov/pubmed/11700396

Hypotensive resuscitation using a polymerized bovine hemoglobin-based oxygen-carrying solution (HBOC-201) leads to reversal of anaerobic metabolism

https://www.ncbi.nlm.nih.gov/pubmed/11426122

Potential of hemoglobin-based oxygen carriers in trauma patients

https://www.ncbi.nlm.nih.gov/pubmed/11805546

Bovine hemoglobin-based oxygen carrier (HBOC-201) for resuscitation of uncontrolled, exsanguinating liver injury in swine. Carolina Resuscitation Research Group.

https://www.ncbi.nlm.nih.gov/pubmed/10670846

Administration of polymerized bovine hemoglobin improves survival in a rat model of traumatic shock

https://www.ncbi.nlm.nih.gov/pubmed/10445236

© 2021 Hemoglobin Oxygen Therapeutics LLC