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Organ Perfusion/Transplantation
Cellular recovery after prolonged warm ischaemia of the whole body.
Andrijevic D, Vrselja Z, Lysyy T, Zhang S, Skarica M, Spajic A, et al.Nature. 2022 Aug 3. Epub ahead of print.
Organ Perfusion/Transplantation
Ex vivo normothermic preservation of amputated limbs with a hemoglobin-based oxygen carrier perfusate
Figueroa BA, Said SA, Ordenana C, Rezaei M, et al.. J Trauma Acute Care Surg. 2022 Feb 1;92(2):388-397.
Organ Perfusion/Transplantation
Perfusate Composition and Duration of Ex-Vivo Normothermic Perfusion in Kidney Transplantation: A Systematic Review.
Fard A, Pearson R, Lathan R, Mark PB, Clancy MJ. Transpl Int. 2022 May 11;35:10236. doi: 10.3389/ti.2022.10236. PMID: 35634582; PMCID: PMC9130468.
Case Reports, Reviews and Editorials
Hemoglobin-glutamer 250 (Bovine)[HBOC-201, Hemopure®] Clinical Use in South Africa and Comprehensive Review of Cardiac Outcomes and Risk/Benefit in Peer-Reviewed, Indexed Studies in Humans and Animal Models.
Jahr JS, Tseng K, Brown AP, Dubé GP. NANOBIOTHERAPEUTIC BASED BLOOD SUBSTITUTES. 2022:207-47.
Case Reports, Reviews and Editorials
Resuscitation of an exsanguinated obstetrics patient with HBOC-201: A case report
Barrett CD, Theodore S, Dechert T, et al. Transfusion. 2022 Aug;62 Suppl 1:S218-S223. doi: 10.1111/trf.16973. Epub 2022 Jun 24. PMID: 35748693.
Organ Perfusion/Transplantation
The Immunological Effect of Oxygen Carriers on Normothermic Ex Vivo Liver Perfusion.
Jennings H, Carlson KN, Little C, Verhagen JC, Nagendran J, Liu Y, et al. Front Immunol. 2022 Jun 22;13:833243. doi: 10.3389/fimmu.2022.833243.
Organ Perfusion/Transplantation
Improved organ recovery after oxygen deprivation.
Porte RJ. Improved organ recovery after oxygen deprivation. Nature. 2022 Aug 3. doi: 10.1038/d41586-022-01995-3. Epub ahead of print.
Case Reports, Reviews and Editorials
Blood Component Requirements and Erythrocyte Transfusion and Mortality Related to Hemoglobin Deficit in Phase III Trial of Hemoglobin-Based Oxygen Carrier: HBOC-201.
Jahr JS, Williams JP. Am J Ther. 2022 May-Jun 01;29(3):e279-e286. Epub 2022 Apr 14. PMID: 35421008.
Organ Perfusion/Transplantation
Comparison of Centrifugal and Pulsatile Perfusion to Preserve Donor Kidneys Using Ex Vivo Subnormothermic Perfusion
Luke PPW, Jiang L, Ruthirakanthan A, et al. Journal of Investigative Surgery, 35:1, 104-110.
Case Reports, Reviews and Editorials
New Applications of HBOC-201: A 25-Year Review of the Literature.
Cao M, Zhao Y, He H, et al. Front Med (Lausanne). 2021 Dec 8;8:794561. doi: 10.3389/fmed.2021.794561. PMID: 34957164; PMCID: PMC8692657.
Case Reports, Reviews and Editorials
Increasing hemoglobin concentration with an artificial oxygen carrier improves severe anemia-induced degraded cognitive function.
Weiskopf RB, Davenport R, Cap AP, et al. J Trauma Acute Care Surg. 2021 Aug 1;91(2S Suppl 2):S182-S185.
Organ Perfusion/Transplantation
Evaluating the Effects of Subnormothermic Perfusion with AP39 in a Novel Blood-Free Model of Ex Vivo Kidney Preservation and Reperfusion.
Juriasingani S, Jackson A, Zhang MY, et al. International Journal of Molecular Sciences. 2021; 22(13):7180.
Case Reports, Reviews and Editorials
Perioperative Management of Patients for Whom Transfusion Is Not an Option
Guinn NR, Resar LM, Frank SM. Perioperative Anesthesiology. 2021 Jun;134(6):939-48.
Case Reports, Reviews and Editorials
Documenting the Sublingual Microcirculation of a Patient with Severe Anemia Undergoing Treatment with a Hemoglobin-Based Oxygen Carrier.
Stankiewicz J, Jeyaraju M, Maheshwari S, et al. In A44. CRITICAL CARE CASE REPORTS: HEMATOLOGY AND ONCOLOGY 2020 May (pp. A1721-A1721). American Thoracic Society.
Hematology/Oncology
When Every Drop of Blood Matters: HBOC 201 and Unconventional Ventilator Strategies to Tide Over Hemolytic Crisis
Chhabria MS, Sharma N, Tong Q, Manogna D, Sheppard TJ. CRITICAL CARE CASE REPORTS: HEMATOLOGY AND ONCOLOGY 2020 May (pp. A1734-A1734). American Thoracic Society.
Organ Perfusion/Transplantation
Metabolic and lipidomic profiling of steatotic human livers during ex situ normothermic machine perfusion guides resuscitation strategies
Raigani S, Karimian N, Huang V, Zhang AM, Beijert I, Geerts S, et al. PLoS One. 2020 Jan 24;15(1):e0228011.
Organ Perfusion/Transplantation
The efficacy of HBOC-201 in ex situ gradual rewarming kidney perfusion in a rat model
Mahboub P, Aburawi M, Karimian N, et al. Artif Organs. 2020 Jan;44(1):81-90. Epub 2019 Aug 1.
Hematology/Oncology
A case study of 10 patients administered HBOC-201 in high doses over a prolonged period: outcomes during severe anemia when transfusion is not an option
Zumberg M, Gorlin J, Griffiths EA, Schwartz G, Fletcher BS, Walsh K, et al. Transfusion. 2020 May 1. [Epub ahead of print]
Case Reports, Reviews and Editorials
The need for an artificial oxygen carrier for disasters and pandemics, including COVID-19.
Weiskopf RB, Glassberg E, Guinn NR, James MFM, Ness PM, Pusateri AE. Transfusion. 2020 Dec;60(12):3039-3045. Epub 2020 Nov 20.
Organ Perfusion/Transplantation
Oxygen Transport during Ex Situ Machine Perfusion of Donor Livers Using Red Blood Cells or Artificial Oxygen Carriers.
Bodewes SB, van Leeuwen OB, Thorne AM, et al. International Journal of Molecular Sciences. 2021; 22(1):235.
Organ Perfusion/Transplantation
Ex-Vivo Normothermic Limb Perfusion With a Hemoglobin-Based Oxygen Carrier Perfusate
Said SA, Ordeñana CX, Rezaei M, et al. Mil Med. 2020 Jan 7;185(Suppl 1):110-120.
Organ Perfusion/Transplantation
Synthetic hemoglobin-based oxygen carriers are an acceptable alternative for packed red blood cells in normothermic kidney perfusion
Aburawi MM, Fontan FM, Karimian N, et al. Am J Transplant. 2019 Oct;19(10):2814-2824. Epub 2019 Apr 26.
Trauma
Use of hemoglobin based oxygen carrier HBOC-021 (Hemopure) as a bridge during emergencies in patients unable to receive blood products: experience at a tertiary care center
Bari S, Rabinovich M, Curry M, et al. Use of hemoglobin based oxygen carrier HBOC-021 (Hemopure) as a bridge during emergencies in patients unable to receive blood products: experience at a tertiary care center. Blood. 2017;130(Suppl 1):4926
Case Reports, Reviews and Editorials
Reassessment of the need for an oxygen carrier for the treatment of traumatic hemorrhage when blood is not an option
Pusateri AE, Glassberg E, Weiskopf RB. Shock. 2019;52(1S Suppl 1):55‐59.
Organ Perfusion/Transplantation
Pretransplant sequential hypo- and normothermic machine perfusion of suboptimal livers donated after circulatory death using a hemoglobin-based oxygen carrier perfusion solution
de Vries Y, Matton APM, Nijsten MWN, Werner MJM, van den Berg AP, de Boer MT, et. al. Am J Transplant. 2019 Apr;19(4):1202-1211. . Epub 2019 Jan 23.
Other
Relative Efficacies of HBOC-201 and Polyheme to Increase Oxygen Transport Compared to Blood and Crystalloids
Dubé GP, Pitman AN, Mackenzie CF. Shock. 2019 Oct;52(1S Suppl 1):100-107.PMID:29140831
Case Reports, Reviews and Editorials
Users guide to pitfalls and lessons learned about HBOC-201 during clinical trials, expanded access, and clinical use in 1,701 patients
Mackenzie CF, Dubé GP, Pitman A, Zafirelis M. Users Guide to Pitfalls and Lessons Learned About HBOC-201 During Clinical Trials, Expanded Access, and Clinical Use in 1,701 Patients. Shock. 2019 Oct;52(1S Suppl 1):92-99. PMID:29076972
Case Reports, Reviews and Editorials
Successful management of the potentially fatal hyperhaemolysis syndrome of sickle cell anaemia with a regimen including bortezomib and Hemopure
Epstein SS, Hadley TJ. J Clin Pharm Ther. 2019 Oct;44(5):815-818. Epub 2019 Jun 25.
Organ Perfusion/Transplantation
Transplantation of High-risk Donor Livers After Ex Situ Resuscitation and Assessment Using Combined Hypo- and Normothermic Machine Perfusion: A Prospective Clinical Trial
van Leeuwen OB, de Vries Y, Fujiyoshi M, Nijsten MWN, Ubbink R, Pelgrim GJ, et. al. Transplantation of High-risk Donor Livers After Ex Situ Resuscitation and Assessment Using Combined Hypo- and Normothermic Machine Perfusion: A Prospective Clinical Trial. Ann Surg. 2019 Nov;270(5):906-914. doi: 10.1097/SLA.0000000000003540. PubMed PMID: 31633615.
Trauma
Freeze-dried plasma mitigates the dilution effects of a hemoglobin-based oxygen carrier (HBOC-201) in a model of resuscitation for hemorrhage and hemodilution
Meledeo MA, Peltier GC, McIntosh CS, Taylor AS, Bynum JA, Pusateri AE, Cap AP. J Trauma Acute Care Surg. 2019 Jul;87(1S Suppl 1):S83-S90.
Organ Perfusion/Transplantation
Restoration of brain circulation and cellular functions hours post-mortem
Vrselja Z., Daniele, S.G., Silbereis, J. et al. Nature 568, 336–343 (2019)
Organ Perfusion/Transplantation
Renal Protection Against Ischemia Perfusion Injury: Hemoglobin Based Oxygen Carrier-201 vs. Blood as an Oxygen Carrier in Ex vivo Subnormothermic Machine Perfusion
Bhattacharjee RN, Patel SVB, Sun Q, et al. Transplantation. 2019 Sep 18. [Epub ahead of print]
Hematology/Oncology
Anti-N and anti-Doa immunoglobulin G alloantibody-mediated delayed hemolytic transfusion reaction with hyperhemolysis in sickle cell disease treated with eculizumab and HBOC-201: case report and review of the literature.
Unnikrishnan A, Pelletier JPR, Bari S, et al. Transfusion. 2019 Jun;59(6):1907-1910.Epub 2019 Feb 15.
Organ Perfusion/Transplantation
Transplantation of high-risk donor livers after resuscitation and viability assessment using a combined protocol of oxygenated hypothermic, rewarming and normothermic machine perfusion: study protocol for a prospective, single-arm study (DHOPE-COR-NMP trial)
de Vries Y, Berendsen TA, Fujiyoshi M, van den Berg AP, Blokzijl H, de Boer MT, et al. BMJ Open. 2019 Aug 15;9(8):e028596. doi: 10.1136/bmjopen-2018-028596.
Organ Perfusion/Transplantation
The impact on the bioenergetic status and oxidative-mediated tissue injury of a combined protocol of hypothermic and normothermic machine perfusion using an acellular haemoglobin-based oxygen carrier: The cold-to-warm machine perfusion of the liver
Boteon YL, Laing RW, Schlegel A, et al. PLoS One. 2019 Oct 23;14(10):e0224066. eCollection 2019.
Trauma
Selective aortic arch perfusion with fresh whole blood or HBOC-201 reverses hemorrhage-induced traumatic cardiac arrest in a lethal model of noncompressible torso hemorrhage
Hoops HE, Manning JE, Graham TL, et al. J Trauma Acute Care Surg. 2019 Aug;87(2):263-273.
Oxyglobin
The effects of hemoglobin glutamer-200 and iNO on pulmonary vascular tone and arterial oxygenation in an experimental acute respiratory distress syndrome
Voelker MT, Bergmann A, Busch T, Jahn N, Laudi S, Noreikat K, et. al. T. Pulm. Pharmacol Ther. 2018 Apr;49:130-133. Epub 2018. Feb 6.
Organ Perfusion/Transplantation
Normothermic machine perfusion of donor livers without the need for human blood products
Matton APM, Burlage LC, van Rijn R, de Vries Y, Karangwa SA, Nijsten MW, et al. Normothermic machine perfusion of donor livers without the need for human blood products. Liver Transpl. 2018 Apr;24(4):528-538. doi: 10.1002/lt.25005. Erratum in: Liver Transpl. 2018 Aug;24(8):1151. PubMed PMID: 29281862; PubMed Central PMCID: PMC5900573.
Case Reports, Reviews and Editorials
Pharmacotherapy in Acutely Anemic Jehovah's Witnesses: An Evidence-Based Review
McConachie SM, Almadrahi Z, Wahby KA, Wilhelm SM. Pharmacotherapy in Acutely Anemic Jehovah's Witnesses: An Evidence-Based Review. Ann Pharmacother. 2018 Sep;52(9):910-919. doi: 10.1177/1060028018766656. Epub 2018 Mar 28. Review. PMID:29592539
Case Reports, Reviews and Editorials
Use of a hemoglobin substitute (HBOC-201) to treat acute anemia in a leukemic patient with anti-Vel antibodies.
Ayyoubi MT, Manapuram S, Hashmi H, McDaniel K, Basu SK, Tse W, Krem MM. Use of a hemoglobin substitute (HBOC-201) to treat acute anemia in a leukemic patient with anti-Vel antibodies. Blood. 2017 Dec 8;130:4928.
Organ Perfusion/Transplantation
Bloodless reperfusion with the oxygen carrier HBOC-201 in acute myocardial infarction: a novel platform for cardioprotective probes delivery. Basic Res Cardiol
García-Ruiz JM, Galán-Arriola C, Fernández-Jiménez R, Aguero J, Sánchez-González J, García-Alvarez A, Nuno-Ayala M, Dubé GP, Zafirelis Z, López-Martín GJ, Bernal JA, Lara-Pezzi E, Fuster V, Ibáñez B. Bloodless reperfusion with the oxygen carrier HBOC-201 in acute myocardial infarction: a novel platform for cardioprotective probes delivery. Basic Res Cardiol. 2017 Mar;112(2):17. doi: 10.1007/s00395-017-0605-6. Epub 2017 Feb 10. PubMed PMID: 28188434.
Case Reports, Reviews and Editorials
Hemoglobin-based oxygen carrier rescues double-transplant patient from life-threatening anemia
Gomez MF, Aljure O, Ciancio G, Lynn M. Hemoglobin-Based Oxygen Carrier Rescues Double-Transplant Patient From Life-Threatening Anemia. Am J Transplant. 2017 Jul;17(7):1941-1944. doi: 10.1111/ajt.14226. Epub 2017 Mar 17. PMID:28188676
Case Reports, Reviews and Editorials
Treatment of individuals who cannot receive blood products for religious or other reasons
Scharman CD, Shatzel JJ, Kim E, et al. Treatment of individuals who cannot receive blood products for religious or other reasons. Am J Hematol. 2017; 92: 1370– 1381.
Case Reports, Reviews and Editorials
Use of the blood substitute HBOC-201 in critically ill patients during sickle crisis: a three-case series
Davis JM, El-Haj N, Shah NN, Schwartz G, Block M, Wall J, Tidswell M, DiNino E. Use of the blood substitute HBOC-201 in critically ill patients during sickle crisis: a three-case series. Transfusion. 2018 Jan;58(1):132-137. doi:10.1111/trf.14386. Epub 2017 Oct 26. PubMed PMID: 29076161.
Surgery
Hemoglobin-Based Oxygen Carrier Rescues Double-Transplant Patient From Life-Threatening Anemia
Gomez MF, Aljure O, Ciancio G, Lynn M. Hemoglobin-Based Oxygen Carrier Rescues Double-Transplant Patient From Life-Threatening Anemia. Am J Transplant. 2017 Jul;17(7):1941-1944. doi: 10.1111/ajt.14226. Epub 2017 Mar 17. PMID:28188676
Other
Normalization of hemoglobin-based oxygen carrier-201 induced vasoconstriction: targeting nitric oxide and endothelin
Taverne YJ, de Wijs-Meijler D, Te Lintel Hekkert M, et al. Normalization of hemoglobin-based oxygen carrier-201 induced vasoconstriction: targeting nitric oxide and endothelin. J Appl Physiol (1985). 2017 May 1;122(5):1227-1237. doi: 10.1152/japplphysiol.00677.2016. Epub 2017 Feb 9. PubMed PMID: 28183818.
Case Reports, Reviews and Editorials
Use of hemoglobin based oxygen carrier HBOC-021 (Hemopure) as a bridge during emergencies in patients unable to receive blood products: experience at a tertiary care center.
Bari S, Rabinovich M, Curry M, et al. Use of hemoglobin based oxygen carrier HBOC-021 (Hemopure) as a bridge during emergencies in patients unable to receive blood products: experience at a tertiary care center. Blood. 2017;130(Suppl 1):4926.
Organ Perfusion/Transplantation
The Use of an Acellular Oxygen Carrier in a Human Liver Model of Normothermic Machine Perfusion
Laing RW, Bhogal RH, Wallace L, Boteon Y, Neil DAH, Smith A, Stephenson BTF, Schlegel A, Hübscher SG, Mirza DF, Afford SC, Mergental H. The Use of an Acellular Oxygen Carrier in a Human Liver Model of Normothermic Machine Perfusion. Transplantation. 2017 Nov;101(11):2746-2756. doi: 10.1097/TP.0000000000001821. PubMed PMID: 28520579; PubMed Central PMCID: PMC5656179
Case Reports, Reviews and Editorials
Oxygen delivery during severe anemia when blood transfusion is refused on religious grounds
Salmen M, Hendriksen S, Gorlin J, LeClaire M, Prekker ME. Oxygen Delivery during Severe Anemia When Blood Transfusion Is Refused on Religious Grounds. Ann Am Thorac Soc. 2017 Jul;14(7):1216-1220. doi: 10.1513/AnnalsATS.201612-1039CC. PubMed PMID: 28665709.
Oxyglobin
Feline non-regenerative immune-mediated anaemia: features and outcome in 15 cases
Black V, Adamantos S, Barfield D, Tasker S. J Feline Med Surg. 2016 Aug;18(8):597-602. doi: 10.1177/1098612X15588800. Epub 2015 Jun 26. PMID:26116621
Hematology/Oncology
Difficult to swallow: warm autoimmune hemolytic anemia in a Jehovah's Witness treated with hemoglobin concentrate complicated by achalasia
Epperla N, Strouse C, VanSandt AM, Foy P. Difficult to swallow: warm autoimmune hemolytic anemia in a Jehovah's Witness treated with hemoglobin concentrate complicated by achalasia. Transfusion. 2016 Jul;56(7):1801-6. doi: 10.1111/trf.13607. Epub 2016 Apr 6. PMID:27062564
Case Reports, Reviews and Editorials
Hemoglobin glutamer-250 (bovine) in South Africa: consensus usage guidelines from clinician experts who have treated patients
Mer M, Hodgson E, Wallis L, Jacobson B, Levien L, Snyman J, et al. Transfusion. 2016 Oct;56(10):2631-2636. doi: 10.1111/trf.13726. Epub 2016 Sep 23. PMID:27658499
Oxyglobin
A successful transfusion in a tamandua (Tamandua tetradactyla) using both whole blood and blood replacement products
Raines JA, Storms T. A successful transfusion in a tamandua (Tamandua tetradactyla) using both whole blood and blood replacement products. J Zoo Wildl Med. 2015 Mar;46(1):161-3. PMID:25831593
Organ Perfusion/Transplantation
Liver preservation with machine perfusion and a newly developed cell-free oxygen carrier solution under subnormothermic conditions
Fontes P, Lopez R, van der Plaats A, Vodovotz Y, Minervini M, Scott V, et al. Liver preservation with machine perfusion and a newly developed cell-free oxygen carrier solution under subnormothermic conditions. Am J Transplant. 2015 Feb;15(2):381-94. PubMed PMID: 25612645
Other
Absence of developmental toxicity in a canine model after infusion of a hemoglobin-based oxygen carrier: Implications for risk assessment
Holson JF, Stump DG, Pearce LB, Watson RE, DeSesso JM. Absence of developmental toxicity in a canine model after infusion of a hemoglobin-based oxygen carrier: Implications for risk assessment. Reprod Toxicol. 2015 Apr;52:101-7. doi: 10.1016/j.reprotox.2015.01.006. Epub 2015 Feb 16. PMID:25697570
Case Reports, Reviews and Editorials
Haemoglobin-based oxygen carriers: indications and future applications
Njoku M, St Peter D, Mackenzie CF. Haemoglobin-based oxygen carriers: indications and future applications. Br J Hosp Med (Lond). 2015 Feb;76(2):78-83. doi: 10.12968/hmed.2015.76.2.78. Review. PubMed PMID: 25671471.
Other
Resuscitation from hemorrhagic shock using polymerized hemoglobin compared to blood
Ortiz D, Barros M, Yan S, Cabrales P. Resuscitation from hemorrhagic shock using polymerized hemoglobin compared to blood. Am J Emerg Med. 2014 Mar;32(3):248-55. doi: 10.1016/j.ajem.2013.11.045. Epub 2013 Dec 7. PMID:24418449 | PMCID:PMC4049234
Trauma
Hypertonic HBOC-201 decreases neutrophil activation after hemorrhagic shock
Rivera-Chávez FA, Lu A, Liu MM, Abdalla A, Minei JP. Hypertonic HBOC-201 decreases neutrophil activation after hemorrhagic shock. J Invest Surg. 2014 Feb;27(1):14-20. doi: 10.3109/08941939.2013.826756. PubMed PMID: 24456255.
Surgery
A safety and efficacy evaluation of hemoglobin-based oxygen carrier HBOC-201 in a randomized, multicenter red blood cell controlled trial in noncardiac surgery patients
Van Hemelrijck J, Levien LJ, Veeckman L, Pitman A, Zafirelis Z, Standl T. A safety and efficacy evaluation of hemoglobin-based oxygen carrier HBOC-201 in a randomized, multicenter red blood cell controlled trial in noncardiac surgery patients. Anesth Analg. 2014 Oct;119(4):766-76. doi: 10.1213/ANE.0000000000000305. PMID:24977631
Trauma
Resuscitation from hemorrhagic shock using polymerized hemoglobin compared to blood
Resuscitation from hemorrhagic shock using polymerized hemoglobin compared to blood. Am J Emerg Med. 2014 Mar;32(3):248-55. doi: 10.1016/j.ajem.2013.11.045. Epub 2013 Dec 7. PMID:24418449 | PMCID:PMC4049234
Case Reports, Reviews and Editorials
Bovine hemoglobin: a nontraditional approach to the management of acute anemia in a Jehovah's Witness patient with autoimmune hemolytic anemia
Jordan SD, Alexander E. Bovine hemoglobin: a nontraditional approach to the management of acute anemia in a Jehovah's Witness patient with autoimmune hemolytic anemia. J Pharm Pract. 2013 Jun;26(3):257-60. doi: 10.1177/0897190012451928. Epub 2012 Aug 6. PMID:22869910
Oxyglobin
HbG200-mediated preinduction of heme oxygenase-1 improves bile flow and ameliorates pericentral downregulation of Bsep and Mrp2 following experimental liver ischemia and reperfusion
Donner MG, Topp SA, Cebula P, Krienen A, Gehrmann T, Sommerfeld A, et al.HbG200-mediated preinduction of heme oxygenase-1 improves bile flow and ameliorates pericentral downregulation of Bsep and Mrp2 following experimental liver ischemia and reperfusion. Biol Chem. 2013 Jan;394(1):97-112. doi: 10.1515/hsz-2012-0153. PMID:23096566
Trauma
Traumatic brain injury and severe uncontrolled haemorrhage with short delay pre-hospital resuscitation in a swine model.
Teranishi K, Scultetus A, Haque A, Stern S, Philbin N, Rice J, Johnson T, et al. Traumatic brain injury and severe uncontrolled haemorrhage with short delay pre-hospital resuscitation in a swine model. Injury. 2012 May;43(5):585-93. doi: 10.1016/j.injury.2010.09.042. Epub 2010 Oct 30. PMID:21036354
Other
Crosslinked, polymerized, and PEG-conjugated hemoglobin-based oxygen carriers: clinical safety and efficacy of recent and current products
Jahr JS, Akha AS, Holtby RJ. Crosslinked, polymerized, and PEG-conjugated hemoglobin-based oxygen carriers: clinical safety and efficacy of recent and current products. Curr Drug Discov Technol. 2012 Sep;9(3):158-65. Review. PMID:21745179
Trauma
New and future resuscitation fluids for trauma patients using hemoglobin and hypertonic saline
Galvagno SM Jr, Mackenzie CF. New and future resuscitation fluids for trauma patients using hemoglobin and hypertonic saline. Anesthesiol Clin. 2013 Mar;31(1):1-19. doi: 10.1016/j.anclin.2012.10.004. Epub 2012 Dec 6. Review. PMID:23351531
Trauma
The effect HBOC-201 and sodium nitrite resuscitation after uncontrolled haemorrhagic shock in swine
Moon-Massat P, Scultetus A, Arnaud F, Brown A, Haque A, Saha B, et al. The effect HBOC-201 and sodium nitrite resuscitation after uncontrolled haemorrhagic shock in swine. Injury. 2012 May;43(5):638-47. doi: 10.1016/j.injury.2010.10.013. Epub 2010 Nov 20. PMID:21094491
Trauma
Pre-hospital resuscitation with HBOC-201 and rFVIIa compared to HBOC-201 alone in uncontrolled hemorrhagic shock in swine
Haque A, Arnaud F, Teranishi K, Okada T, Kim B, Moon-Massat PF, et al. Pre-hospital resuscitation with HBOC-201 and rFVIIa compared to HBOC-201 alone in uncontrolled hemorrhagic shock in swine. Artif Cells Blood Substit Immobil Biotechnol. 2012 Feb;40(1-2):44-55. doi: 10.3109/10731199.2011.585615. Epub 2011 Aug 2. PMID:21806503
Surgery
New and future resuscitation fluids for trauma patients using hemoglobin and hypertonic saline
Galvagno SM Jr, Mackenzie CF. New and future resuscitation fluids for trauma patients using hemoglobin and hypertonic saline. Anesthesiol Clin. 2013 Mar;31(1):1-19. doi: 10.1016/j.anclin.2012.10.004. Epub 2012 Dec 6. Review. PMID:23351531
Trauma
A synthetic haemoglobin-based oxygen carrier and the reversal of cardiac hypoxia secondary to severe anaemia following trauma
Fitzgerald MC, Chan JY, Ross AW, Liew SM, Butt WW, Baguley D, Salem HH, Russ MK, Deasy C, Martin KE, Mathew JK, Rosenfeld JV. A synthetic haemoglobin-based oxygen carrier and the reversal of cardiac hypoxia secondary to severe anaemia following trauma. Med J Aust. 2011 May 2;194(9):471-3. PMID:21534906
Trauma
Vasoactive hemoglobin solution improves survival in hemodilution followed by hemorrhagic shock
Vázquez BY, Hightower CM, Martini J, Messmer C, Frienesenecker B, Corbels P, et al. Vasoactive hemoglobin solution improves survival in hemodilution followed by hemorrhagic shock. Crit Care Med. 2011 Jun;39(6):1461-6. doi: 10.1097/CCM.0b013e3182120cdb. PMID:21336111 | PMCID:PMC3318980
Trauma
Is there a role for hemopure in the prehospital setting?
Minei JP. Is there a role for hemopure in the prehospital setting? J Trauma. 2011 May;70(5 Suppl):S38-9. doi: 10.1097/TA.0b013e31821a5a09. Review. No abstract available. PMID:21841569
Trauma
A bovine hemoglobin-based oxygen carrier as pump prime for cardiopulmonary bypass: reduced systemic lactic acidosis and improved cerebral oxygen metabolism during low flow in a porcine model
McNeil JD, Propper B, Walker J, Holguin L, Evans L, Lee K, et al. A bovine hemoglobin-based oxygen carrier as pump prime for cardiopulmonary bypass: reduced systemic lactic acidosis and improved cerebral oxygen metabolism during low flow in a porcine model. J Thorac Cardiovasc Surg. 2011 Aug;142(2):411-7. doi: 10.1016/j.jtcvs.2010.11.017. PMID:21641005
Trauma
Amylase and lipase detection in hemorrhaged animals treated with HBOC-201
Arnaud F, McCarron R, Freilich D. Amylase and lipase detection in hemorrhaged animals treated with HBOC-201.
Artif Cells Blood Substit Immobil Biotechnol. 2011 Jun;39(3):155-61. doi: 10.3109/10731199.2010.516260. Epub 2010 Dec 21. PMID:21171938
Surgery
Vital organ tissue oxygenation after serial normovolemic exchange transfusion with HBOC-201 in anesthetized swine
Muir WW, Ilangovan G, Zweier JL, Moon-Massat PF, Rentko VT. Vital organ tissue oxygenation after serial normovolemic exchange transfusion with HBOC-201 in anesthetized swine. Shock 2011 Jun;35(6):597-603. doi: 10.1097/SHK.0b013e31821366f6. PMID:21330945 | PMCID:PMC3221463
Trauma
Hemoglobin-based oxygen carrier (HBOC-201) and escalating doses of recombinant factor VIIa (rFVIIa) as a novel pre-hospital resuscitation fluid in a swine model of severe uncontrolled hemorrhage
Scultetus A, Arnaud F, Kaplan L, Shander A, Philbin N, Rice J, McCarron R, et al. Hemoglobin-based oxygen carrier (HBOC-201) and escalating doses of recombinant factor VIIa (rFVIIa) as a novel pre-hospital resuscitation fluid in a swine model of severe uncontrolled hemorrhage. Artif Cells Blood Substit Immobil Biotechnol. 2011 Apr;39(2):59-68. Epub 2010 Jul 20. PMID:20645681
Oxyglobin
Evaluation of the effects of bovine hemoglobin glutamer-200 on systolic arterial blood pressure in hypotensive cats: 44 cases (1997-2008)
Wehausen CE, Kirby R, Rudloff E. Evaluation of the effects of bovine hemoglobin glutamer-200 on systolic arterial blood pressure in hypotensive cats: 44 cases (1997-2008). J Am Vet Med Assoc. 2011 Apr 1;238(7):909-14. doi: 10.2460/javma.238.7.909. PMID:21453180
Case Reports, Reviews and Editorials
Hemoglobin-based oxygen carriers: compassionate use and compassionate clinical trials
Weiskopf RB. Hemoglobin-based oxygen carriers: compassionate use and compassionate clinical trials. Anesth Analg. 2010 Mar 1;110(3):659-62. doi: 10.1213/ANE.0b013e3181c85255. No abstract available. PMID:20185643
Hematology/Oncology
Management of acute anemia in a Jehovah's Witness patient with acute lymphoblastic leukemia with polymerized bovine hemoglobin-based oxygen carrier: a case report
Donahue LL, Shapira I, Shander A, Kolitz J, Allen S, Greenburg G. Management of acute anemia in a Jehovah's Witness patient with acute lymphoblastic leukemia with polymerized bovine hemoglobin-based oxygen carrier: a case report and review of literature. Transfusion. 2010 Jul;50(7):1561-7. doi: 10.1111/j.1537-2995.2010.02603.x. Epub 2010 Apr 23. Review. PMID:20456679
Case Reports, Reviews and Editorials
When blood is not an option: factors affecting survival after the use of a hemoglobin-based oxygen carrier in 54 patients with life-threatening anemia
Mackenzie CF, Moon-Massat PF, Shander A, Javidroozi M, Greenburg AG.
When blood is not an option: factors affecting survival after the use of a hemoglobin-based oxygen carrier in 54 patients with life-threatening anemia. Anesth Analg. 2010 Mar 1;110(3):685-93. doi: 10.1213/ANE.0b013e3181cd473b. PMID:20042443
Trauma
Nitroglycerin attenuates vasoconstriction of HBOC-201 during hemorrhagic shock resuscitation
Katz LM, Manning JE, McCurdy S, Sproule C, McGwin G Jr, Moon-Massat P, et al. Nitroglycerin attenuates vasoconstriction of HBOC-201 during hemorrhagic shock resuscitation. Resuscitation. 2010 Apr;81(4):481-7. doi: 10.1016/j.resuscitation.2009.12.015. Epub 2010 Jan 18. PMID:20080328
Case Reports, Reviews and Editorials
Reconstructing hemoglobin-based oxygen carriers
Greenburg AG, Light WR, Dubé GP. Reconstructing hemoglobin-based oxygen carriers. Transfusion. 2010 Dec;50(12):2764-7; author reply 2767. doi: 10.1111/j.1537-2995.2010.02814.x. No abstract available. PMID:21126254
Cardiovascular
Preoxygenated hemoglobin-based oxygen carrier HBOC-201 annihilates myocardial ischemia during brief coronary artery occlusion in pigs
Te Lintel Hekkert M, Dubé GP, Regar E, de Boer M, Vranckx P, van der Giessen WJ, Serruys PW, Duncker DJ.
Preoxygenated hemoglobin-based oxygen carrier HBOC-201 annihilates myocardial ischemia during brief coronary artery occlusion in pigs. Am J Physiol Heart Circ Physiol. 2010 Mar;298(3):H1103-13. doi: 10.1152/ajpheart.00667.2009. Epub 2010 Jan 8. PMID:20061545
Case Reports, Reviews and Editorials
HBOC-201 use in traumatic brain injury: case report and review of literature
Marinaro J, Smith J, Tawil I, Billstrand M, Crookston KP. HBOC-201 use in traumatic brain injury: case report and review of literature. Transfusion. 2009 Oct;49(10):2054-9. doi: 10.1111/j.1537-2995.2009.02235.x. Epub 2009 May 27. Review. PMID:19497051
Surgery
Does HBOC-201 (Hemopure) affect platelet function in orthopedic surgery: a single-site analysis from a multicenter study
Jahr JS, Liu H, Albert OK, Gull A, Moallempour M, Lim J, Gosselin R. Does HBOC-201 (Hemopure) affect platelet function in orthopedic surgery: a single-site analysis from a multicenter study. Am J Ther. 2010 Mar-Apr;17(2):140-7. doi: 10.1097/MJT.0b013e3181a2b08d. PMID:19417588
Case Reports, Reviews and Editorials
The use of Hemopure® at Groote Schuur hospital, Cape Town: 4 case studies
HE Potgieter & MF James (2009) The use of Hemopure® at Groote Schuur hospital, Cape Town: 4 case studies, Southern African Journal of Anaesthesia and Analgesia, 15:1, 13-15, DOI: 10.1080/22201173.2009.10872581
Surgery
The use of Hemopure® at Groote Schuur hospital, Cape Town: 4 case studies, Southern African Journal of Anaesthesia and Analgesia
HE Potgieter & MF James (2009) The use of Hemopure® at Groote Schuur hospital, Cape Town: 4 case studies, Southern African Journal of Anaesthesia and Analgesia, 15:1, 13-15, DOI: 10.1080/22201173.2009.10872581
Oxyglobin
Comparison of fluid types for resuscitation after acute blood loss in mallard ducks (Anas platyrhynchos)
Lichtenberger M, Orcutt C, Cray C, Thamm DH, DeBehnke D, Page C, et al. Comparison of fluid types for resuscitation after acute blood loss in mallard ducks (Anas platyrhynchos). J Vet Emerg Crit Care (San Antonio). 2009 Oct;19(5):467-72. doi: 10.1111/j.1476-4431.2009.00465.x. PMID:19821888
Other
Haemoglobin-based oxygen carriers: is the benefit worth the risk?
Mackenzie CF. Haemoglobin-based oxygen carriers: is the benefit worth the risk? Br J Hosp Med (Lond). 2009 Jan;70(1):26-30. PMID:19357574
Cardiovascular
Do approved blood substitutes reduce myocardial infarction size: is this the critical question?
Jahr J. Do approved blood substitutes reduce myocardial infarction size: is this the critical question? Br J Anaesth. 2009 Oct;103(4):470-1. doi: 10.1093/bja/aep227. No abstract available. PMID:19749116
Other
Prevention of the pulmonary vasoconstrictor effects of HBOC-201 in awake lambs by continuously breathing nitric oxide. Anesthesiology.
Yu B, Volpato GP, Chang K, Bloch KD, Zapol WM. Prevention of the pulmonary vasoconstrictor effects of HBOC-201 in awake lambs by continuously breathing nitric oxide. Anesthesiology. 2009 Jan;110(1):113-22. doi: 10.1097/ALN.0b013e318190bc4f. PMID:19104178 | PMCID:PMC2704389
Cardiovascular
Administration of bovine polymerized haemoglobin before and during coronary occlusion reduces infarct size in rabbits
Rempf C, Standl T, Schenke K, Chammas K, Gottschalk A, Burmeister MA, et al. Administration of bovine polymerized haemoglobin before and during coronary occlusion reduces infarct size in rabbits. Br J Anaesth. 2009 Oct;103(4):496-504. doi: 10.1093/bja/aep233. Epub 2009 Aug 26. PMID:19710071
Surgery
Regional blood flow after serial normovolemic exchange transfusion with HBOC-201 (Hemopure) in anesthetized swine
Mongan PD, Moon-Massat PF, Rentko V, Mihok S, Dragovich A, Sharma P. Regional blood flow after serial normovolemic exchange transfusion with HBOC-201 (Hemopure) in anesthetized swine. J Trauma. 2009 Jul;67(1):51-60. doi: 10.1097/TA.0b013e3181838030. PMID:19590308
Oxyglobin
A prospective, randomized comparison of Oxyglobin (HB-200) and packed red blood cell transfusion for canine babesiosis
Zambelli AB, Leisewitz AL. A prospective, randomized comparison of Oxyglobin (HB-200) and packed red blood cell transfusion for canine babesiosis. J Vet Emerg Crit Care (San Antonio). 2009 Feb;19(1):102-12. doi: 10.1111/j.1476-4431.2009.00386.x. PMID:19691591
Oxyglobin
Successful treatment of a southern Pacific rattlesnake (Crotalus viridis helleri) bite in a caracal (Caracal caracal)
Singleton CL, Oosterhuis JE, Seibold K, Lamberski N. Successful treatment of a southern Pacific rattlesnake (Crotalus viridis helleri) bite in a caracal (Caracal caracal). J Zoo Wildl Med. 2009 Jun;40(2):378-81. PMID:19569491
Other
Sodium nitrite therapy attenuates the hypertensive effects of HBOC-201 via nitrite reduction
Rodriguez C, Vitturi DA, He J, Vandromme M, Brandon A, Hutchings A, Rue LW 3rd, Kerby JD, Patel RP. Sodium nitrite therapy attenuates the hypertensive effects of HBOC-201 via nitrite reduction. Biochem J. 2009 Aug 27;422(3):423-32. doi: 10.1042/BJ20090735. PMID:19555351 | PMCID:PMC2775055
Oxyglobin
Methemoglobin effects on coagulation: a dose-response study with HBOC-200 (Oxyglobin) in a thrombelastogram model
Moallempour M, Jahr JS, Lim JC, Weeks D, Butch A, Driessen B. Methemoglobin effects on coagulation: a dose-response study with HBOC-200 (Oxyglobin) in a thrombelastogram model. J Cardiothorac Vasc Anesth. 2009 Feb;23(1):41-7. doi: 10.1053/j.jvca.2008.06.006. Epub 2008 Aug 29. PMID:18834828
Cardiovascular
Effects of hemodilution with a hemoglobin-based oxygen carrier (HBOC-201) on ischemia/reperfusion injury in a model of partial warm liver ischemia of the rat
Zapletal C, Bode A, Lorenz MW, Gebhard MM, Golling M. Effects of hemodilution with a hemoglobin-based oxygen carrier (HBOC-201) on ischemia/reperfusion injury in a model of partial warm liver ischemia of the rat. Microvasc Res. 2009 Dec;78(3):386-92. doi: 10.1016/j.mvr.2009.08.005. Epub 2009 Aug 26. PMID:19715706
Surgery
HBOC-201 vasoactivity in a phase III clinical trial in orthopedic surgery subjects--extrapolation of potential risk for acute trauma trials
Freilich D, Pearce LB, Pitman A, Greenburg G, Berzins M, Bebris L, et al. HBOC-201 vasoactivity in a phase III clinical trial in orthopedic surgery subjects--extrapolation of potential risk for acute trauma trials. J Trauma. 2009 Feb;66(2):365-76. doi: 10.1097/TA.0b013e3181820d5c. PMID:19204509
Trauma
Resuscitation with the hemoglobin-based oxygen carrier, HBOC-201, in a swine model of severe uncontrolled hemorrhage and traumatic brain injury
Stern S, Rice J, Philbin N, McGwin G, Arnaud F, Johnson T, et al. Resuscitation with the hemoglobin-based oxygen carrier, HBOC-201, in a swine model of severe uncontrolled hemorrhage and traumatic brain injury. Shock. 2009 Jan;31(1):64-79. doi: 10.1097/SHK.0b013e3181778dc3. PMID:18497706
Other
Blood alternative products: correction regarding Jehovah's Witnesses.
Muller CF. Blood alternative products: correction regarding Jehovah's Witnesses. S Afr Med J. 2009 Feb;99(2):72, 74; author reply 74. No abstract available. PMID:19422107
Trauma
Innate immune response after resuscitation with hemoglobin-based oxygen carrier and recombinant factor VIIA in uncontrolled hemorrhagic shock in a swine model
Malkevich NV, Dong F, Vandermolen CA, Philbin NB, Rice JP, Scultetus A, et al. Innate immune response after resuscitation with hemoglobin-based oxygen carrier and recombinant factor VIIA in uncontrolled hemorrhagic shock in a swine model. J Trauma. 2008 Jun;64(6):1498-510. doi: 10.1097/TA.0b013e3181454a05. PMID:18545114
Cardiovascular
Haemodynamic effects, safety, and tolerability of haemoglobin-based oxygen carrier-201 in patients undergoing PCI for CAD
Serruys PW, Vranckx P, Slagboom T, Regar E, Meliga E, de Winter RJ, et al. Haemodynamic effects, safety, and tolerability of haemoglobin-based oxygen carrier-201 in patients undergoing PCI for CAD. EuroIntervention. 2008 Mar;3(5):600-9. PMID:19608488
Hematology/Oncology
Hemoglobin-based oxygen carrier enhanced tumor oxygenation: a novel strategy for cancer therapy
Gundersen SI, Palmer AF. Hemoglobin-based oxygen carrier enhanced tumor oxygenation: a novel strategy for cancer therapy. Biotechnol Prog. 2008 Nov-Dec;24(6):1353-64. doi: 10.1002/btpr.56. PMID:19194950
Other
Modern Cross-linking Strategies for Synthesizing Acellular Hemoglobin-Based Oxygen Carriers
Harris DR, Palmer AF. Modern cross-linking strategies for synthesizing acellular hemoglobin-based oxygen carriers. Biotechnol Prog. 2008 Nov-Dec;24(6):1215-25. doi: 10.1002/btpr.85. Review. PMID:19194934 | PMCID:PMC2637476
Cardiovascular
Proof-of-concept trial to evaluate haemoglobin based oxygen therapeutics in elective percutaneous coronary revascularisation. Rationale, protocol design and haemodynamic results
Meliga E, Vranckx P, Regar E, Kint PP, Duncker DJ, Serruys PW. Proof-of-concept trial to evaluate haemoglobin based oxygen therapeutics in elective percutaneous coronary revascularisation. Rationale, protocol design and haemodynamic results. EuroIntervention. 2008 May;4(1):99-107. PMID:19112786
Surgery
Haemoglobin, oxygen carriers and perioperative organ perfusion
Kocian R, Spahn DR. Haemoglobin, oxygen carriers and perioperative organ perfusion. Best Pract Res Clin Anaesthesiol. 2008 Mar;22(1):63-80. Review. PMID:18494389
Oxyglobin
Measuring circulating blood volume using infused hemoglobin-based oxygen carrier (oxyglobin) as an indicator: verification in a canine hypovolemia model
Jahr JS, Lurie F, Bezdikian V, Driessen B, Gunther RA. Measuring circulating blood volume using infused hemoglobin-based oxygen carrier (oxyglobin) as an indicator: verification in a canine hypovolemia model. Am J Ther. 2008 Mar-Apr;15(2):98-101. doi: 10.1097/MJT.0b013e31804c6f98. PMID:18356627
Oxyglobin
Clinical use of a haemoglobin-based oxygen carrying solution (Oxyglobin) in 48 cats (2002-2006)
Weingart C, Kohn B. Clinical use of a haemoglobin-based oxygen carrying solution (Oxyglobin) in 48 cats (2002-2006). J Feline Med Surg. 2008 Oct;10(5):431-8. doi: 10.1016/j.jfms.2007.10.012. Epub 2008 May 2. PMID:18455461
Case Reports, Reviews and Editorials
Management of hemorrhagic shock when blood is not an option
Mackenzie CF, Morrison C, Jaberi M, Genuit T, Katamuluwa S, Rodriguez A. Management of hemorrhagic shock when blood is not an option. J Clin Anesth. 2008 Nov;20(7):538-41. doi: 10.1016/j.jclinane.2008.05.012. Epub 2008 Nov 18. PMID:19019664
Trauma
Use of hemoglobin-based oxygen-carrying solution-201 to improve resuscitation parameters and prevent secondary brain injury in a swine model of traumatic brain injury and hemorrhage: laboratory investigation
Rosenthal G, Morabito D, Cohen M, Roeytenberg A, Derugin N, Panter SS, et al. Use of hemoglobin-based oxygen-carrying solution-201 to improve resuscitation parameters and prevent secondary brain injury in a swine model of traumatic brain injury and hemorrhage: laboratory investigation. J Neurosurg. 2008 Mar;108(3):575-87. doi: 10.3171/JNS/2008/108/3/0575. PMID:18312106
Other
Metanalysis critical of blood alternative product challenged
Bateman C. Metanalysis critical of blood alternative product challenged. S Afr Med J. 2008 Oct;98(10):746, 748. No abstract available. PMID:19115744
Trauma
Hemoglobin-based oxygen carrying compound-201 as salvage therapy for severe neuro- and polytrauma (Injury Severity Score = 27-41
Dudkiewicz M, Harpaul TA, Proctor KG. Hemoglobin-based oxygen carrying compound-201 as salvage therapy for severe neuro- and polytrauma (Injury Severity Score = 27-41). Crit Care Med. 2008 Oct;36(10):2838-48. doi: 10.1097/CCM.0b013e318186f6b3. PMID:18766094
Other
HBOC-201, hemoglobin glutamer-250 (bovine), Hemopure (Biopure Corporation)
Jahr JS, Moallempour M, Lim JC. HBOC-201, hemoglobin glutamer-250 (bovine), Hemopure (Biopure Corporation). Expert Opin Biol Ther. 2008 Sep;8(9):1425-33. doi: 10.1517/14712598.8.9.1425 . Review. PMID:18694360
Hematology/Oncology
Bovine Blood and Neuromuscular Paralysis as a Bridge to Recovery in a Patent with Severe Autoimmune Hemolytic Anemia
Pachinburavan M, Marik PE. Bovine blood and neuromuscular paralysis as a bridge to recovery in a patient with severe autoimmune hemolytic anemia. Clin Transl Sci. 2008 Sep;1(2):172-3. doi: 10.1111/j.1752-8062.2008.00006.x. PMID:20443842 | PMCID:PMC5439555
Oxyglobin
Hemoglobin-glutamer 200 reduces reperfusion injury of the cold preserved rat liver by induction of heme oxygenase-1
Topp SA, Krieg A, Koch A, Tidden CM, Ramp U, Hohlfeld T, et al. Hemoglobin-glutamer 200 reduces reperfusion injury of the cold preserved rat liver by induction of heme oxygenase-1. J Surg Res. 2008 Dec;150(2):243-54. doi: 10.1016/j.jss.2008.02.033. Epub 2008 Mar 18. PMID:18395753
Surgery
HBOC-201 as an alternative to blood transfusion: efficacy and safety evaluation in a multicenter phase III trial in elective orthopedic surgery
Jahr JS, Mackenzie C, Pearce LB, Pitman A, Greenburg AG. HBOC-201 as an alternative to blood transfusion: efficacy and safety evaluation in a multicenter phase III trial in elective orthopedic surgery. J Trauma. 2008 Jun;64(6):1484-97. doi:
Other
HBOC-201: the multi-purpose oxygen therapeutic
Dubé GP, Vranckx P, Greenburg AG. HBOC-201: the multi-purpose oxygen therapeutic. EuroIntervention. 2008 May;4(1):161-5. Review. PMID:19112795
Trauma
Hematologic effects of recombinant factor VIIa combined with hemoglobin-based oxygen carrier-201 for prehospital resuscitation of swine with severe uncontrolled hemorrhage due to liver injury
Arnaud F, Hammett M, Philbin N, Scultetus A, McCarron R, Freilich D. Hematologic effects of recombinant factor VIIa combined with hemoglobin-based oxygen carrier-201 for prehospital resuscitation of swine with severe uncontrolled hemorrhage due to liver injury. Blood Coagul Fibrinolysis. 2008 Oct;19(7):669-77. doi: 10.1097/MBC.0b013e3283089198. PMID:18832908
Surgery
Resuscitation following severe, controlled hemorrhage associated with a 24 h delay to surgical intervention in swine using a hemoglobin based oxygen carrier as an oxygen bridge to definitive care
Philbin N, Handrigan M, Rice J, McNickle K, McGwin G, Williams R, et al. Resuscitation following severe, controlled hemorrhage associated with a 24 h delay to surgical intervention in swine using a hemoglobin based oxygen carrier as an oxygen bridge to definitive care. Resuscitation. 2007 Aug;74(2):332-43. Epub 2007 Mar 23. PMID:17383073
Trauma
Innate immune responses in Swine resuscitated from severe traumatic hemorrhagic shock with hemoglobin-based oxygen carrier-201
Hall C, Malkevich N, Handrigan M, Vandermolen C, Aranaud F, Hong J, et al. Innate immune responses in Swine resuscitated from severe traumatic hemorrhagic shock with hemoglobin-based oxygen carrier-201. Artif Cells Blood Substit Immobil Biotechnol. 2007;35(3):259-74. PMID:17573626
Trauma
Hematology patterns after hemoglobin-based oxygen carrier resuscitation from severe controlled hemorrhage with prolonged delayed definitive care
Arnaud F, Fasipe D, Philbin N, Rice J, Flournoy WS, Ahlers S, et al. Hematology patterns after hemoglobin-based oxygen carrier resuscitation from severe controlled hemorrhage with prolonged delayed definitive care. Transfusion. 2007 Nov;47(11):2098-109. PMID:17958540
Trauma
Immune effects of decreasing low-molecular weight hemoglobin components of hemoglobin-based oxygen carriers (HBOC) in a swine model of severe controlled hemorrhagic shock
VanderMolen C, Malkevich N, Philbin N, Rice J, Collier S, Hall C, et al. Immune effects of decreasing low-molecular weight hemoglobin components of hemoglobin-based oxygen carriers (HBOC) in a swine model of severe controlled hemorrhagic shock. Artif Cells Blood Substit Immobil Biotechnol. 2007;35(5):507-17. PMID:17922315
Other
Effects of Hemopure on maximal oxygen uptake and endurance performance in healthy humans
Ashenden MJ, Schumacher YO, Sharpe K, Varlet-Marie E, Audran M. Effects of Hemopure on maximal oxygen uptake and endurance performance in healthy humans. Int J Sports Med. 2007 May;28(5):381-5. Epub 2006 Oct 6. PMID:17024639
Hematology/Oncology
Bovine hemoglobin (glutamer-250, Hemopure)-specific immunoglobulin G antibody cross-reacts with human hemoglobin but does not lyse red blood cells in vitro
Hamilton RG, Kickler TS. Bovine hemoglobin (glutamer-250, Hemopure)-specific immunoglobulin G antibody cross-reacts with human hemoglobin but does not lyse red blood cells in vitro. Transfusion. 2007 Apr;47(4):723-8. PMID:17381632
Hematology/Oncology
Hemopure transfusion in a child with severe anemia
Stefan DC, Uys R, Wessels G. Hemopure transfusion in a child with severe anemia. Pediatr Hematol Oncol. 2007 Jun;24(4):269-73. PMID:17613869.
Other
Hemoglobin-based O2 carrier O2 affinity and capillary inlet pO2 are important factors that influence O2 transport in a capillary
Dimino ML, Palmer AF. Hemoglobin-based O2 carrier O2 affinity and capillary inlet pO2 are important factors that influence O2 transport in a capillary. Biotechnol Prog. 2007 Jul-Aug;23(4):921-31. Epub 2007 Jun 8. PMID:17555329 | PMCID:PMC2533853
Other
Artificial oxygen carriers: a current review
Henkel-Honke T, Oleck M. Artificial oxygen carriers: a current review. AANA J. 2007 Jun;75(3):205-11. Review. PMID:17591302
Trauma
Resuscitation following severe, controlled hemorrhage associated with a 24 h delay to surgical intervention in swine using a hemoglobin based oxygen carrier as an oxygen bridge to definitive care
Philbin N, Handrigan M, Rice J, McNickle K, McGwin G, Williams R, et al. Resuscitation following severe, controlled hemorrhage associated with a 24 h delay to surgical intervention in swine using a hemoglobin based oxygen carrier as an oxygen bridge to definitive care. Resuscitation. 2007 Aug;74(2):332-43. Epub 2007 Mar 23. PMID:17383073
Trauma
Resuscitation from hemorrhagic shock comparing standard hemoglobin-based oxygen carrier (HBOC)-201 versus 7.5% hypertonic HBOC-201
Rivera-Chavez FA, Huerta S, Brown R, York GB, Minei JP. Resuscitation from hemorrhagic shock comparing standard hemoglobin-based oxygen carrier (HBOC)-201 versus 7.5% hypertonic HBOC-201. J Trauma. 2007 Nov;63(5):1113-9. PMID:17993959
Trauma
Resuscitation from hemorrhagic shock with HBOC-201 in the setting of traumatic brain injury
Kerby JD, Sainz JG, Zhang F, Hutchings A, Sprague S, Farrokhi FR, et al. Resuscitation from hemorrhagic shock with HBOC-201 in the setting of traumatic brain injury. Shock. 2007 Jun;27(6):652-6. PMID:17505305
Oxyglobin
Effects of low-volume hemoglobin glutamer-200 versus normal saline and arginine vasopressin resuscitation on systemic and skeletal muscle blood flow and oxygenation in a canine hemorrhagic shock model
Driessen B, Zarucco L, Gunther RA, Burns PM, Lamb SV, Vincent SE, et al. Effects of low-volume hemoglobin glutamer-200 versus normal saline and arginine vasopressin resuscitation on systemic and skeletal muscle blood flow and oxygenation in a canine hemorrhagic shock model. Crit Care Med. 2007 Sep;35(9):2101-9. PMID:17581486
Other
Blood substitutes as pharmacotherapies in clinical practice
ahr JS, Walker V, Manoochehri K. Blood substitutes as pharmacotherapies in clinical practice. Curr Opin Anaesthesiol. 2007 Aug;20(4):325-30. Review. PMID:17620840
Trauma
Coagulation patterns following haemoglobin-based oxygen carrier resuscitation in severe uncontrolled haemorrhagic shock in swine
Arnaud F, Handrigan M, Hammett M, Philbin N, Rice J, Dong F, et al. Coagulation patterns following haemoglobin-based oxygen carrier resuscitation in severe uncontrolled haemorrhagic shock in swine. Transfus Med. 2006 Aug;16(4):290-302. PMID:16879158
Trauma
Systemic function, oxygenation and microvascular correlation during treatment of hemorrhagic shock with blood substitutes
Cheung AT, Duong PL, Driessen B, Chen PC, Jahr JS, Gunther RA. Systemic function, oxygenation and microvascular correlation during treatment of hemorrhagic shock with blood substitutes. Clin Hemorheol Microcirc. 2006;34(1-2):325-34. PMID:16543653
Surgery
A comparison of the acute hemodynamic and delayed effects of 50% exchange transfusion with two different cross-linked hemoglobin based oxygen carrying solutions and Pentastarch
Bonegio RG, Fuhro R, Ragno G, Robert Valeri C, Lieberthal W. A comparison of the acute hemodynamic and delayed effects of 50% exchange transfusion with two different cross-linked hemoglobin based oxygen carrying solutions and Pentastarch. Artif Cells Blood Substit Immobil Biotechnol. 2006;34(2):145-57. PMID:16537171
Cardiovascular
A polymerized bovine hemoglobin oxygen carrier preserves regional myocardial function and reduces infarct size after acute myocardial ischemia
George I, Yi GH, Schulman AR, Morrow BT, Cheng Y, Gu A, et al. A polymerized bovine hemoglobin oxygen carrier preserves regional myocardial function and reduces infarct size after acute myocardial ischemia. Am J Physiol Heart Circ Physiol. 2006 Sep;291(3):H1126-37. Epub 2006 Apr 14. PMID:16617139
Trauma
Bovine polymerized hemoglobin (hemoglobin-based oxygen carrier-201) resuscitation in three swine models of hemorrhagic shock with militarily relevant delayed evacuation--effects on histopathology and organ function
Johnson T, Arnaud F, Dong F, Philbin N, Rice J, Asher L, et al. Bovine polymerized hemoglobin (hemoglobin-based oxygen carrier-201) resuscitation in three swine models of hemorrhagic shock with militarily relevant delayed evacuation--effects on histopathology and organ function. Crit Care Med. 2006 May;34(5):1464-74. PMID:16540964
Trauma
Bovine polymerized hemoglobin versus Hextend resuscitation in a swine model of severe controlled hemorrhagic shock with delay to definitive care
Rice J, Philbin N, McGwin G, Arnaud F, Johnson T, Flournoy WS, et al. Bovine polymerized hemoglobin versus Hextend resuscitation in a swine model of severe controlled hemorrhagic shock with delay to definitive care. Shock. 2006 Sep;26(3):302-10. PMID:16912657
Trauma
Prehospital HBOC-201 after traumatic brain injury and hemorrhagic shock in swine
Patel MB, Feinstein AJ, Saenz AD, Majetschak M, Proctor KG. Prehospital HBOC-201 after traumatic brain injury and hemorrhagic shock in swine. J Trauma. 2006 Jul;61(1):46-56. PMID:16832248
Other
Oxygen radical formation does not have an impact in the treatment of severe acute experimental pancreatitis using free cellular hemoglobin
treatment of severe acute experimental pancreatitis using free cellular hemoglobin. World J Gastroenterol. 2006 May 14;12(18):2914-8. PMID:16718818 | PMCID:PMC4087810
Oxyglobin
Effects of isovolemic resuscitation with hemoglobin-based oxygen carrier Hemoglobin glutamer-200 (bovine) on systemic and mesenteric perfusion and oxygenation in a canine model of hemorrhagic shock: a comparison with 6% hetastarch solution and shed blood
Driessen B, Jahr JS, Lurie F, Gunther RA.
Effects of isovolemic resuscitation with hemoglobin-based oxygen carrier Hemoglobin glutamer-200 (bovine) on systemic and mesenteric perfusion and oxygenation in a canine model of hemorrhagic shock: a comparison with 6% hetastarch solution and shed blood. Vet Anaesth Analg. 2006 Nov;33(6):368-80. PMID:17083609
Trauma
Immune effects of resuscitation with HBOC-201, a hemoglobin-based oxygen carrier, in swine with moderately severe hemorrhagic shock from controlled hemorrhage
Dong F, Hall CH, Golech SA, Philbin NB, Rice JP, Gurney J, et al. Immune effects of resuscitation with HBOC-201, a hemoglobin-based oxygen carrier, in swine with moderately severe hemorrhagic shock from controlled hemorrhage. Shock. 2006 Jan;25(1):50-5. PMID:16369186
Other
Acute and long-term effects of modified hemoglobin (HBOC-201) in a rat model of hypertension and chronic kidney disease
Baylis C. Acute and long-term effects of modified hemoglobin (HBOC-201) in a rat model of hypertension and chronic kidney disease. Transfusion. 2006 Jul;46(7):1104-11. PMID:16836556
Surgery
Bovine hemoglobin-based oxygen-carrying solution (HBOC-201) improves flap survival in a rat model of epigastric flap failure
Ortegon DP, Davis MR, Sampson JB, Dick EJ, Kashyap V, Kerby JD. Bovine hemoglobin-based oxygen-carrying solution (HBOC-201) improves flap survival in a rat model of epigastric flap failure. Microsurgery. 2006;26(3):203-6. PMID:16493668
Oxyglobin
Improvement of impaired microcirculation and tissue oxygenation by hemodilution with hydroxyethyl starch plus cell-free hemoglobin in acute porcine pancreatitis
Freitag M, Standl TG, Kleinhans H, Gottschalk A, Mann O, Rempf C, Bachmann K, Gocht A, Petri S, Izbicki JR, Strate T. Improvement of impaired microcirculation and tissue oxygenation by hemodilution with hydroxyethyl starch plus cell-free hemoglobin in acute porcine pancreatitis. Pancreatology. 2006;6(3):232-9. Epub 2006 Mar 9. PMID:16534248
Trauma
A hemoglobin-based oxygen carrier, bovine polymerized hemoglobin (HBOC-201) versus hetastarch (HEX) in a moderate severity hemorrhagic shock swine model with delayed evacuation
Philbin N, Rice J, Gurney J, McGwin G, Arnaud F, Dong F, et al. A hemoglobin-based oxygen carrier, bovine polymerized hemoglobin (HBOC-201) versus hetastarch (HEX) in a moderate severity hemorrhagic shock swine model with delayed evacuation. Resuscitation. 2005 Sep;66(3):367-78. PMID:16081200
Hematology/Oncology
Influence of the hemoglobin solution HBOC-201 on tissue oxygenation in the rat R1H-tumor
Gottschalk A, Raabe A, Hommel M, Rempf C, Freitag M, Standl T. Influence of the hemoglobin solution HBOC-201 on tissue oxygenation in the rat R1H-tumor. Artif Cells Blood Substit Immobil Biotechnol. 2005;33(4):379-89. PMID:16317957
Other
Enhanced central organ oxygenation after application of bovine cell-free hemoglobin HBOC-201
Freitag M, Standl TG, Gottschalk A, Burmeister MA, Rempf C, Horn EP, et al. Enhanced central organ oxygenation after application of bovine cell-free hemoglobin HBOC-201. Can J Anaesth. 2005 Nov;52(9):904-14. PMID:16251554
Oxyglobin
N-terminal adducts of bovine hemoglobin with glutaraldehyde in a hemoglobin-based oxygen carrier
Gasthuys M, Alves S, Tabet JC. N-terminal adducts of bovine hemoglobin with glutaraldehyde in a hemoglobin-based oxygen carrier. Anal Chem. 2005 May 15;77(10):3372-8. PMID:15889931
Other
Structural and functional characterization of glutaraldehyde-polymerized bovine hemoglobin and its isolated fractions
Buehler PW, Boykins RA, Jia Y, Norris S, Freedberg DI, Alayash AI. Structural and functional characterization of glutaraldehyde-polymerized bovine hemoglobin and its isolated fractions. Anal Chem. 2005 Jun 1;77(11):3466-78. PMID:15924377
Trauma
Resuscitation with a hemoglobin-based oxygen carrier after traumatic brain injury
King DR, Cohn SM, Proctor KG. Resuscitation with a hemoglobin-based oxygen carrier after traumatic brain injury. J Trauma. 2005 Sep;59(3):553-60; discussion 560-2. PMID:16361895