All Publications

Organ Perfusion/ Transplantation

Comparison of Centrifugal and Pulsatile Perfusion to Preserve Donor Kidneys Using Ex Vivo Subnormothermic Perfusion

Case Reports, Reviews and Editorials

Documenting the Sublingual Microcirculation of a Patient with Severe Anemia Undergoing Treatment with a Hemoglobin-Based Oxygen Carrier.

Organ Perfusion/ Transplantation

Ex-Vivo Normothermic Limb Perfusion With a Hemoglobin-Based Oxygen Carrier Perfusate

Hematology/Oncology

A case study of 10 patients administered HBOC-201 in high doses over a prolonged period: outcomes during severe anemia when transfusion is not an option

Hematology/Oncology

When Every Drop of Blood Matters: HBOC 201 and Unconventional Ventilator Strategies to Tide Over Hemolytic Crisis

Organ Perfusion/ Transplantation

Metabolic and lipidomic profiling of steatotic human livers during ex situ normothermic machine perfusion guides resuscitation strategies

Organ Perfusion/ Transplantation

The efficacy of HBOC-201 in ex situ gradual rewarming kidney perfusion in a rat model

Case Reports, Reviews and Editorials

The need for an artificial oxygen carrier for disasters and pandemics, including COVID-19.

Organ Perfusion/ Transplantation

Synthetic hemoglobin-based oxygen carriers are an acceptable alternative for packed red blood cells in normothermic kidney perfusion

Hematology/Oncology

Anti-N and anti-Doa immunoglobulin G alloantibody-mediated delayed hemolytic transfusion reaction with hyperhemolysis in sickle cell disease treated with eculizumab and HBOC-201: case report and review of the literature.

Organ Perfusion/ Transplantation

Renal Protection Against Ischemia Perfusion Injury: Hemoglobin Based Oxygen Carrier-201 vs. Blood as an Oxygen Carrier in Ex vivo Subnormothermic Machine Perfusion

Trauma

Selective aortic arch perfusion with fresh whole blood or HBOC-201 reverses hemorrhage-induced traumatic cardiac arrest in a lethal model of noncompressible torso hemorrhage

Organ Perfusion/ Transplantation

Restoration of brain circulation and cellular functions hours post-mortem

Organ Perfusion/ Transplantation

The impact on the bioenergetic status and oxidative-mediated tissue injury of a combined protocol of hypothermic and normothermic machine perfusion using an acellular haemoglobin-based oxygen carrier: The cold-to-warm machine perfusion of the liver

Other

Relative Efficacies of HBOC-201 and Polyheme to Increase Oxygen Transport Compared to Blood and Crystalloids

Organ Perfusion/ Transplantation

Transplantation of High-risk Donor Livers After Ex Situ Resuscitation and Assessment Using Combined Hypo- and Normothermic Machine Perfusion: A Prospective Clinical Trial

Hematology/Oncology

Successful management of the potentially fatal hyperhaemolysis syndrome of sickle cell anaemia with a regimen including bortezomib and Hemopure

Trauma

Freeze-dried plasma mitigates the dilution effects of a hemoglobin-based oxygen carrier (HBOC-201) in a model of resuscitation for hemorrhage and hemodilution

Case Reports, Reviews and Editorials

Successful management of the potentially fatal hyperhaemolysis syndrome of sickle cell anaemia with a regimen including bortezomib and Hemopure

Organ Perfusion/ Transplantation

Pretransplant sequential hypo- and normothermic machine perfusion of suboptimal livers donated after circulatory death using a hemoglobin-based oxygen carrier perfusion solution

Trauma

Use of hemoglobin based oxygen carrier HBOC-021 (Hemopure) as a bridge during emergencies in patients unable to receive blood products: experience at a tertiary care center

Surgery

Transplantation of High-risk Donor Livers After Ex Situ Resuscitation and Assessment Using Combined Hypo- and Normothermic Machine Perfusion: A Prospective Clinical Trial

Organ Perfusion/ Transplantation

Transplantation of high-risk donor livers after resuscitation and viability assessment using a combined protocol of oxygenated hypothermic, rewarming and normothermic machine perfusion: study protocol for a prospective, single-arm study (DHOPE-COR-NMP trial)

Case Reports, Reviews and Editorials

Reassessment of the need for an oxygen carrier for the treatment of traumatic hemorrhage when blood is not an option

Trauma

Reassessment of the need for an oxygen carrier for the treatment of traumatic hemorrhage when blood is not an option

Surgery

Users Guide to Pitfalls and Lessons Learned About HBOC-201 During Clinical Trials, Expanded Access, and Clinical Use in 1,701 Patients

Surgery

Transplantation of high-risk donor livers after resuscitation and viability assessment using a combined protocol of oxygenated hypothermic, rewarming and normothermic machine perfusion: study protocol for a prospective, single-arm study (DHOPE-COR-NMP trial)

Case Reports, Reviews and Editorials

Users guide to pitfalls and lessons learned about HBOC-201 during clinical trials, expanded access, and clinical use in 1,701 patients

Organ Perfusion/ Transplantation

Normothermic machine perfusion of donor livers without the need for human blood products

Oxyglobin

The effects of hemoglobin glutamer-200 and iNO on pulmonary vascular tone and arterial oxygenation in an experimental acute respiratory distress syndrome

Case Reports, Reviews and Editorials

Pharmacotherapy in Acutely Anemic Jehovah's Witnesses: An Evidence-Based Review

Hematology/Oncology

Use of the blood substitute HBOC-201 in critically ill patients during sickle crisis: a three-case series

Surgery

Hemoglobin-Based Oxygen Carrier Rescues Double-Transplant Patient From Life-Threatening Anemia

Cardiovascular

Bloodless reperfusion with the oxygen carrier HBOC-201 in acute myocardial infarction: a novel platform for cardioprotective probes delivery. Basic Res Cardiol

Case Reports, Reviews and Editorials

Treatment of individuals who cannot receive blood products for religious or other reasons

Case Reports, Reviews and Editorials

Oxygen delivery during severe anemia when blood transfusion is refused on religious grounds

Case Reports, Reviews and Editorials

Hemoglobin-based oxygen carrier rescues double-transplant patient from life-threatening anemia

Case Reports, Reviews and Editorials

Use of the blood substitute HBOC-201 in critically ill patients during sickle crisis: a three-case series

Case Reports, Reviews and Editorials

Use of hemoglobin based oxygen carrier HBOC-021 (Hemopure) as a bridge during emergencies in patients unable to receive blood products: experience at a tertiary care center.

Organ Perfusion/ Transplantation

The Use of an Acellular Oxygen Carrier in a Human Liver Model of Normothermic Machine Perfusion

Other

Normalization of hemoglobin-based oxygen carrier-201 induced vasoconstriction: targeting nitric oxide and endothelin

Hematology/Oncology

Difficult to swallow: warm autoimmune hemolytic anemia in a Jehovah's Witness treated with hemoglobin concentrate complicated by achalasia

Oxyglobin

Feline non-regenerative immune-mediated anaemia: features and outcome in 15 cases

Case Reports, Reviews and Editorials

Hemoglobin glutamer-250 (bovine) in South Africa: consensus usage guidelines from clinician experts who have treated patients

Oxyglobin

A successful transfusion in a tamandua (Tamandua tetradactyla) using both whole blood and blood replacement products

Case Reports, Reviews and Editorials

Haemoglobin-based oxygen carriers: indications and future applications

Organ Perfusion/ Transplantation

Liver preservation with machine perfusion and a newly developed cell-free oxygen carrier solution under subnormothermic conditions

Other

Absence of developmental toxicity in a canine model after infusion of a hemoglobin-based oxygen carrier: Implications for risk assessment

Surgery

A safety and efficacy evaluation of hemoglobin-based oxygen carrier HBOC-201 in a randomized, multicenter red blood cell controlled trial in noncardiac surgery patients

Other

Resuscitation from hemorrhagic shock using polymerized hemoglobin compared to blood

Trauma

Experience with the use of Hemopure in the care of a massively burned adult

Trauma

Resuscitation from hemorrhagic shock using polymerized hemoglobin compared to blood

Trauma

Hypertonic HBOC-201 decreases neutrophil activation after hemorrhagic shock

Oxyglobin

HbG200-mediated preinduction of heme oxygenase-1 improves bile flow and ameliorates pericentral downregulation of Bsep and Mrp2 following experimental liver ischemia and reperfusion

Case Reports, Reviews and Editorials

Bovine hemoglobin: a nontraditional approach to the management of acute anemia in a Jehovah's Witness patient with autoimmune hemolytic anemia

Trauma

New and future resuscitation fluids for trauma patients using hemoglobin and hypertonic saline

Trauma

Pre-hospital resuscitation with HBOC-201 and rFVIIa compared to HBOC-201 alone in uncontrolled hemorrhagic shock in swine

Other

Crosslinked, polymerized, and PEG-conjugated hemoglobin-based oxygen carriers: clinical safety and efficacy of recent and current products

Trauma

Traumatic brain injury and severe uncontrolled haemorrhage with short delay pre-hospital resuscitation in a swine model.

Surgery

New and future resuscitation fluids for trauma patients using hemoglobin and hypertonic saline

Trauma

The effect HBOC-201 and sodium nitrite resuscitation after uncontrolled haemorrhagic shock in swine

Trauma

A bovine hemoglobin-based oxygen carrier as pump prime for cardiopulmonary bypass: reduced systemic lactic acidosis and improved cerebral oxygen metabolism during low flow in a porcine model

Trauma

A synthetic haemoglobin-based oxygen carrier and the reversal of cardiac hypoxia secondary to severe anaemia following trauma

Trauma

Amylase and lipase detection in hemorrhaged animals treated with HBOC-201

Trauma

Vasoactive hemoglobin solution improves survival in hemodilution followed by hemorrhagic shock

Trauma

Hemoglobin-based oxygen carrier (HBOC-201) and escalating doses of recombinant factor VIIa (rFVIIa) as a novel pre-hospital resuscitation fluid in a swine model of severe uncontrolled hemorrhage

Oxyglobin

Evaluation of the effects of bovine hemoglobin glutamer-200 on systolic arterial blood pressure in hypotensive cats: 44 cases (1997-2008)

Trauma

Is there a role for hemopure in the prehospital setting?

Surgery

Vital organ tissue oxygenation after serial normovolemic exchange transfusion with HBOC-201 in anesthetized swine

Case Reports, Reviews and Editorials

Reconstructing hemoglobin-based oxygen carriers

Cardiovascular

Preoxygenated hemoglobin-based oxygen carrier HBOC-201 annihilates myocardial ischemia during brief coronary artery occlusion in pigs

Surgery

Does HBOC-201 (Hemopure) affect platelet function in orthopedic surgery: a single-site analysis from a multicenter study

Trauma

Nitroglycerin attenuates vasoconstriction of HBOC-201 during hemorrhagic shock resuscitation

Hematology/Oncology

Management of acute anemia in a Jehovah's Witness patient with acute lymphoblastic leukemia with polymerized bovine hemoglobin-based oxygen carrier: a case report

Case Reports, Reviews and Editorials

HBOC-201 use in traumatic brain injury: case report and review of literature

Case Reports, Reviews and Editorials

When blood is not an option: factors affecting survival after the use of a hemoglobin-based oxygen carrier in 54 patients with life-threatening anemia

Case Reports, Reviews and Editorials

Hemoglobin-based oxygen carriers: compassionate use and compassionate clinical trials

Case Reports, Reviews and Editorials

The use of Hemopure® at Groote Schuur hospital, Cape Town: 4 case studies

Other

Prevention of the pulmonary vasoconstrictor effects of HBOC-201 in awake lambs by continuously breathing nitric oxide. Anesthesiology.

Cardiovascular

Effects of hemodilution with a hemoglobin-based oxygen carrier (HBOC-201) on ischemia/reperfusion injury in a model of partial warm liver ischemia of the rat

Cardiovascular

Administration of bovine polymerized haemoglobin before and during coronary occlusion reduces infarct size in rabbits

Other

Sodium nitrite therapy attenuates the hypertensive effects of HBOC-201 via nitrite reduction

Trauma

Resuscitation with the hemoglobin-based oxygen carrier, HBOC-201, in a swine model of severe uncontrolled hemorrhage and traumatic brain injury

Surgery

HBOC-201 vasoactivity in a phase III clinical trial in orthopedic surgery subjects--extrapolation of potential risk for acute trauma trials

Oxyglobin

A prospective, randomized comparison of Oxyglobin (HB-200) and packed red blood cell transfusion for canine babesiosis

Cardiovascular

Do approved blood substitutes reduce myocardial infarction size: is this the critical question?

Other

Blood alternative products: correction regarding Jehovah's Witnesses.

Surgery

The use of Hemopure® at Groote Schuur hospital, Cape Town: 4 case studies, Southern African Journal of Anaesthesia and Analgesia

Oxyglobin

Successful treatment of a southern Pacific rattlesnake (Crotalus viridis helleri) bite in a caracal (Caracal caracal)

Oxyglobin

Comparison of fluid types for resuscitation after acute blood loss in mallard ducks (Anas platyrhynchos)

Other

Haemoglobin-based oxygen carriers: is the benefit worth the risk?

Surgery

Regional blood flow after serial normovolemic exchange transfusion with HBOC-201 (Hemopure) in anesthetized swine

Oxyglobin

Methemoglobin effects on coagulation: a dose-response study with HBOC-200 (Oxyglobin) in a thrombelastogram model

Oxyglobin

Measuring circulating blood volume using infused hemoglobin-based oxygen carrier (oxyglobin) as an indicator: verification in a canine hypovolemia model

Other

Metanalysis critical of blood alternative product challenged

Hematology/Oncology

Hemoglobin-based oxygen carrier enhanced tumor oxygenation: a novel strategy for cancer therapy

Trauma

Hematologic effects of recombinant factor VIIa combined with hemoglobin-based oxygen carrier-201 for prehospital resuscitation of swine with severe uncontrolled hemorrhage due to liver injury

Other

Modern Cross-linking Strategies for Synthesizing Acellular Hemoglobin-Based Oxygen Carriers

Trauma

Hemoglobin-based oxygen carrying compound-201 as salvage therapy for severe neuro- and polytrauma (Injury Severity Score = 27-41

Surgery

Haemoglobin, oxygen carriers and perioperative organ perfusion

Cardiovascular

Proof-of-concept trial to evaluate haemoglobin based oxygen therapeutics in elective percutaneous coronary revascularisation. Rationale, protocol design and haemodynamic results

Cardiovascular

Haemodynamic effects, safety, and tolerability of haemoglobin-based oxygen carrier-201 in patients undergoing PCI for CAD

Trauma

Use of hemoglobin-based oxygen-carrying solution-201 to improve resuscitation parameters and prevent secondary brain injury in a swine model of traumatic brain injury and hemorrhage: laboratory investigation

Other

HBOC-201: the multi-purpose oxygen therapeutic

Surgery

HBOC-201 as an alternative to blood transfusion: efficacy and safety evaluation in a multicenter phase III trial in elective orthopedic surgery

Trauma

Innate immune response after resuscitation with hemoglobin-based oxygen carrier and recombinant factor VIIA in uncontrolled hemorrhagic shock in a swine model

Hematology/Oncology

Bovine Blood and Neuromuscular Paralysis as a Bridge to Recovery in a Patent with Severe Autoimmune Hemolytic Anemia

Oxyglobin

Hemoglobin-glutamer 200 reduces reperfusion injury of the cold preserved rat liver by induction of heme oxygenase-1

Other

HBOC-201, hemoglobin glutamer-250 (bovine), Hemopure (Biopure Corporation)

Oxyglobin

Clinical use of a haemoglobin-based oxygen carrying solution (Oxyglobin) in 48 cats (2002-2006)

Case Reports, Reviews and Editorials

Management of hemorrhagic shock when blood is not an option

Hematology/Oncology

Bovine hemoglobin (glutamer-250, Hemopure)-specific immunoglobulin G antibody cross-reacts with human hemoglobin but does not lyse red blood cells in vitro

Trauma

Immune effects of decreasing low-molecular weight hemoglobin components of hemoglobin-based oxygen carriers (HBOC) in a swine model of severe controlled hemorrhagic shock

Other

Blood substitutes as pharmacotherapies in clinical practice

Surgery

Resuscitation following severe, controlled hemorrhage associated with a 24 h delay to surgical intervention in swine using a hemoglobin based oxygen carrier as an oxygen bridge to definitive care

Trauma

Resuscitation from hemorrhagic shock comparing standard hemoglobin-based oxygen carrier (HBOC)-201 versus 7.5% hypertonic HBOC-201

Other

Artificial oxygen carriers: a current review

Oxyglobin

Effects of low-volume hemoglobin glutamer-200 versus normal saline and arginine vasopressin resuscitation on systemic and skeletal muscle blood flow and oxygenation in a canine hemorrhagic shock model

Trauma

Hematology patterns after hemoglobin-based oxygen carrier resuscitation from severe controlled hemorrhage with prolonged delayed definitive care

Trauma

Resuscitation from hemorrhagic shock with HBOC-201 in the setting of traumatic brain injury

Trauma

Innate immune responses in Swine resuscitated from severe traumatic hemorrhagic shock with hemoglobin-based oxygen carrier-201

Other

Effects of Hemopure on maximal oxygen uptake and endurance performance in healthy humans

Other

Hemoglobin-based O2 carrier O2 affinity and capillary inlet pO2 are important factors that influence O2 transport in a capillary

Trauma

Resuscitation following severe, controlled hemorrhage associated with a 24 h delay to surgical intervention in swine using a hemoglobin based oxygen carrier as an oxygen bridge to definitive care

Hematology/Oncology

Hemopure transfusion in a child with severe anemia

Oxyglobin

Improvement of impaired microcirculation and tissue oxygenation by hemodilution with hydroxyethyl starch plus cell-free hemoglobin in acute porcine pancreatitis

Trauma

Prehospital HBOC-201 after traumatic brain injury and hemorrhagic shock in swine

Surgery

Bovine hemoglobin-based oxygen-carrying solution (HBOC-201) improves flap survival in a rat model of epigastric flap failure

Surgery

A comparison of the acute hemodynamic and delayed effects of 50% exchange transfusion with two different cross-linked hemoglobin based oxygen carrying solutions and Pentastarch

Trauma

Immune effects of resuscitation with HBOC-201, a hemoglobin-based oxygen carrier, in swine with moderately severe hemorrhagic shock from controlled hemorrhage

Trauma

Bovine polymerized hemoglobin versus Hextend resuscitation in a swine model of severe controlled hemorrhagic shock with delay to definitive care

Oxyglobin

Effects of isovolemic resuscitation with hemoglobin-based oxygen carrier Hemoglobin glutamer-200 (bovine) on systemic and mesenteric perfusion and oxygenation in a canine model of hemorrhagic shock: a comparison with 6% hetastarch solution and shed blood

Trauma

Bovine polymerized hemoglobin (hemoglobin-based oxygen carrier-201) resuscitation in three swine models of hemorrhagic shock with militarily relevant delayed evacuation--effects on histopathology and organ function

Other

Oxygen radical formation does not have an impact in the treatment of severe acute experimental pancreatitis using free cellular hemoglobin

Other

Acute and long-term effects of modified hemoglobin (HBOC-201) in a rat model of hypertension and chronic kidney disease

Trauma

Systemic function, oxygenation and microvascular correlation during treatment of hemorrhagic shock with blood substitutes

Trauma

Coagulation patterns following haemoglobin-based oxygen carrier resuscitation in severe uncontrolled haemorrhagic shock in swine

Cardiovascular

A polymerized bovine hemoglobin oxygen carrier preserves regional myocardial function and reduces infarct size after acute myocardial ischemia

Cardiovascular

A novel hemoglobin-based blood substitute protects against myocardial reperfusion injury

Oxyglobin

Microcirculatory function and tissue damage is improved after therapeutic injection of bovine hemoglobin in severe acute rodent pancreatitis

Hematology/Oncology

Long-term transfusion of polymerized bovine hemoglobin in a Jehovah's Witness following chemotherapy for myeloid leukemia: a case report

Other

Structural and functional characterization of glutaraldehyde-polymerized bovine hemoglobin and its isolated fractions

Oxyglobin

N-terminal adducts of bovine hemoglobin with glutaraldehyde in a hemoglobin-based oxygen carrier

Cardiovascular

Cardioprotection before revascularization in ischemic myocardial injury and the potential role of hemoglobin-based oxygen carriers

Other

Enhanced central organ oxygenation after application of bovine cell-free hemoglobin HBOC-201

Trauma

Resuscitation with a hemoglobin-based oxygen carrier after traumatic brain injury

Other

Hemopure's process demonstrates TSE and viral clearance

Trauma

Effects of bovine polymerized hemoglobin on coagulation in controlled hemorrhagic shock in swine

Oxyglobin

Effects of prophylactic or therapeutic application of bovine haemoglobin HBOC-200 on ischaemia-reperfusion injury following acute coronary ligature in rats

Trauma

Prolonged low-volume resuscitation with HBOC-201 in a large-animal survival model of controlled hemorrhage

Hematology/Oncology

Influence of the hemoglobin solution HBOC-201 on tissue oxygenation in the rat R1H-tumor

Oxyglobin

The pharmacokinetics of hemoglobin-based oxygen carrier hemoglobin glutamer-200 bovine in the horse

Trauma

A hemoglobin-based oxygen carrier, bovine polymerized hemoglobin (HBOC-201) versus hetastarch (HEX) in a moderate severity hemorrhagic shock swine model with delayed evacuation

Other

The use of a hemoglobin-based oxygen-carrying solution (HBOC-201) for extracorporeal membrane oxygenation in a porcine model with acute respiratory distress syndrome

Trauma

Resuscitation with a blood substitute causes vasoconstriction without nitric oxide scavenging in a model of arterial hemorrhage

Surgery

The effects of a polymerized bovine-derived hemoglobin solution in a rabbit model of arterial thrombosis and bleeding

Cardiovascular

The effects of a polymerized bovine-derived hemoglobin solution in a rabbit model of arterial thrombosis and bleeding

Oxyglobin

Transfusion medicine in exotic pets

Oxyglobin

Detection of hemoglobin-based oxygen carriers in human serum for doping analysis: confirmation by size-exclusion HPLC

Oxyglobin

Confirmation and quantification of hemoglobin-based oxygen carriers in equine and human plasma by hyphenated liquid chromatography tandem mass spectrometry

Other

Hemoglobin-based oxygen carriers

Other

The effect of hemopure on coagulation in clinically relevant concentrations