Peer Reviewed Literature

Taka MA, Sener A. PD31-06 THE EFFECT OF KIDNEY PRESERVATION AT 10° C WITH HEMOPURE AND HYDROGEN SULFIDE DONOR, SODIUM THIOSULFATE, IN A SYNGENEIC RAT RENAL TRANSPLANTATION MODEL. The Journal of Urology. 2023 Apr;209(Supplement 4):e902.

Meyers A, Duarte-Bateman D, Almalak M, Kopparthy V, Rampazzo A, Gharb BB. EX-VIVO LIMB PERFUSION. European Journal of Transplantation. 2023 Mar 21:143-54.

Kharga A, Chen H, Taggart M, Mojoudi M, Yeh H, Uygun K, Markmann JF. 338.3: Utilization of oxygenated hemopure based University of Wisconsin solution during simulated procurement, back-benching, and graft implantation to minimize ischemic reperfusion injury in a rat liver transplantation simulated on pump. Transplantation. 2023 Oct 1;107(10S2):147-8.

Jahr JS, Williams JP. Am J Ther. 2022 May-Jun 01;29(3):e279-e286. Epub 2022 Apr 14. PMID: 35421008.

Porte RJ. Improved organ recovery after oxygen deprivation. Nature. 2022 Aug 3. doi: 10.1038/d41586-022-01995-3. Epub ahead of print.

Jennings H, Carlson KN, Little C, Verhagen JC, Nagendran J, Liu Y, et al. Front Immunol. 2022 Jun 22;13:833243. doi: 10.3389/fimmu.2022.833243.

Barrett CD, Theodore S, Dechert T, et al. Transfusion. 2022 Aug;62 Suppl 1:S218-S223. doi: 10.1111/trf.16973. Epub 2022 Jun 24. PMID: 35748693.

Waters, J.H., Lim, J.C., Blanckenberg, J.M., Jahr, J.S. (2022). HBOC-201: History, Clinical Trials, and Path Forward. In: Liu, H., Kaye, A.D., Jahr, J.S. (eds) Blood Substitutes and Oxygen Biotherapeutics. Springer, Cham. https://doi.org/10.1007/978-3-030-95975-3_35

Jahr JS, Tseng K, Brown AP, Dubé GP. NANOBIOTHERAPEUTIC BASED BLOOD SUBSTITUTES. 2022:207-47.

Fard A, Pearson R, Lathan R, Mark PB, Clancy MJ. Transpl Int. 2022 May 11;35:10236. doi: 10.3389/ti.2022.10236. PMID: 35634582; PMCID: PMC9130468.

Figueroa BA, Said SA, Ordenana C, Rezaei M, et al.. J Trauma Acute Care Surg. 2022 Feb 1;92(2):388-397.

Andrijevic D, Vrselja Z, Lysyy T, Zhang S, Skarica M, Spajic A, et al.Nature. 2022 Aug 3. Epub ahead of print.

Moein M, Ahmed M, Arafa F, Saidi RF. Hemoglobin-Based Oxygen Carriers: Clinical Application of HBOC-201 As an Alternative to Red Blood Cells for Machine Perfusion in Liver Transplantation. Surgery in Practice and Science. 2022 Aug 20:100120.

Kanani T, Isherwood J, Chung WY, Tang S, Alnabati N, Haigh R, West K, Oggioni MR, Garcea G, Dennison A. A O03 Ex vivo perfusion of isolated human liver segments: the development of a novel model for ethical, translational research. British Journal of Surgery. 2022 Dec 14;109(Supplement_9):znac404-003.

Guinn NR, Resar LM, Frank SM. Perioperative Anesthesiology. 2021 Jun;134(6):939-48.

Juriasingani S, Jackson A, Zhang MY, et al. International Journal of Molecular Sciences. 2021; 22(13):7180.

Weiskopf RB, Davenport R, Cap AP, et al. J Trauma Acute Care Surg. 2021 Aug 1;91(2S Suppl 2):S182-S185.

Cao M, Zhao Y, He H, et al. Front Med (Lausanne). 2021 Dec 8;8:794561. doi: 10.3389/fmed.2021.794561. PMID: 34957164; PMCID: PMC8692657.

Luke PPW, Jiang L, Ruthirakanthan A, et al. Journal of Investigative Surgery, 35:1, 104-110.

Said SA, Ordeñana CX, Rezaei M, et al. Mil Med. 2020 Jan 7;185(Suppl 1):110-120.

Bodewes SB, van Leeuwen OB, Thorne AM, et al. International Journal of Molecular Sciences. 2021; 22(1):235.

Weiskopf RB, Glassberg E, Guinn NR, James MFM, Ness PM, Pusateri AE. Transfusion. 2020 Dec;60(12):3039-3045. Epub 2020 Nov 20.

Nellis JR, Devinney MJ, Young CC (2020) Hemopure, HBOC-201, for Life Threatening Anemia in a Jehovah's Witness. Int J Blood Res Disord 7:052. doi.org/10.23937/2469-5696/1410052

Zumberg M, Gorlin J, Griffiths EA, Schwartz G, Fletcher BS, Walsh K, et al. Transfusion. 2020 May 1. [Epub ahead of print]

Mahboub P, Aburawi M, Karimian N, et al. Artif Organs. 2020 Jan;44(1):81-90. Epub 2019 Aug 1.

Raigani S, Karimian N, Huang V, Zhang AM, Beijert I, Geerts S, et al. PLoS One. 2020 Jan 24;15(1):e0228011.

Chhabria MS, Sharma N, Tong Q, Manogna D, Sheppard TJ. CRITICAL CARE CASE REPORTS: HEMATOLOGY AND ONCOLOGY 2020 May (pp. A1734-A1734). American Thoracic Society.

Stankiewicz J, Jeyaraju M, Maheshwari S, et al. In A44. CRITICAL CARE CASE REPORTS: HEMATOLOGY AND ONCOLOGY 2020 May (pp. A1721-A1721). American Thoracic Society.

Hoops HE, Manning JE, Graham TL, et al. J Trauma Acute Care Surg. 2019 Aug;87(2):263-273.

Boteon YL, Laing RW, Schlegel A, et al. PLoS One. 2019 Oct 23;14(10):e0224066. eCollection 2019.

de Vries Y, Berendsen TA, Fujiyoshi M, van den Berg AP, Blokzijl H, de Boer MT, et al. BMJ Open. 2019 Aug 15;9(8):e028596. doi: 10.1136/bmjopen-2018-028596.

Unnikrishnan A, Pelletier JPR, Bari S, et al. Transfusion. 2019 Jun;59(6):1907-1910.Epub 2019 Feb 15.

Bhattacharjee RN, Patel SVB, Sun Q, et al. Transplantation. 2019 Sep 18. [Epub ahead of print]

Vrselja Z., Daniele, S.G., Silbereis, J. et al. Nature 568, 336–343 (2019)

Meledeo MA, Peltier GC, McIntosh CS, Taylor AS, Bynum JA, Pusateri AE, Cap AP. J Trauma Acute Care Surg. 2019 Jul;87(1S Suppl 1):S83-S90.

van Leeuwen OB, de Vries Y, Fujiyoshi M, Nijsten MWN, Ubbink R, Pelgrim GJ, et. al. Transplantation of High-risk Donor Livers After Ex Situ Resuscitation and Assessment Using Combined Hypo- and Normothermic Machine Perfusion: A Prospective Clinical Trial. Ann Surg. 2019 Nov;270(5):906-914. doi: 10.1097/SLA.0000000000003540. PubMed PMID: 31633615.

Epstein SS, Hadley TJ. J Clin Pharm Ther. 2019 Oct;44(5):815-818. Epub 2019 Jun 25.

Mackenzie CF, Dubé GP, Pitman A, Zafirelis M. Users Guide to Pitfalls and Lessons Learned About HBOC-201 During Clinical Trials, Expanded Access, and Clinical Use in 1,701 Patients. Shock. 2019 Oct;52(1S Suppl 1):92-99. PMID:29076972

Dubé GP, Pitman AN, Mackenzie CF. Shock. 2019 Oct;52(1S Suppl 1):100-107.PMID:29140831

de Vries Y, Matton APM, Nijsten MWN, Werner MJM, van den Berg AP, de Boer MT, et. al. Am J Transplant. 2019 Apr;19(4):1202-1211. . Epub 2019 Jan 23.

Pusateri AE, Glassberg E, Weiskopf RB. Shock. 2019;52(1S Suppl 1):55‐59.

Bari S, Rabinovich M, Curry M, et al. Use of hemoglobin based oxygen carrier HBOC-021 (Hemopure) as a bridge during emergencies in patients unable to receive blood products: experience at a tertiary care center. Blood. 2017;130(Suppl 1):4926

Aburawi MM, Fontan FM, Karimian N, et al. Am J Transplant. 2019 Oct;19(10):2814-2824. Epub 2019 Apr 26.

McConachie SM, Almadrahi Z, Wahby KA, Wilhelm SM. Pharmacotherapy in Acutely Anemic Jehovah's Witnesses: An Evidence-Based Review. Ann Pharmacother. 2018 Sep;52(9):910-919. doi: 10.1177/1060028018766656. Epub 2018 Mar 28. Review. PMID:29592539

Matton APM, Burlage LC, van Rijn R, de Vries Y, Karangwa SA, Nijsten MW, et al. Normothermic machine perfusion of donor livers without the need for human blood products. Liver Transpl. 2018 Apr;24(4):528-538. doi: 10.1002/lt.25005. Erratum in: Liver Transpl. 2018 Aug;24(8):1151. PubMed PMID: 29281862; PubMed Central PMCID: PMC5900573.

Voelker MT, Bergmann A, Busch T, Jahn N, Laudi S, Noreikat K, et. al. T. Pulm. Pharmacol Ther. 2018 Apr;49:130-133. Epub 2018. Feb 6.

Salmen M, Hendriksen S, Gorlin J, LeClaire M, Prekker ME. Oxygen Delivery during Severe Anemia When Blood Transfusion Is Refused on Religious Grounds. Ann Am Thorac Soc. 2017 Jul;14(7):1216-1220. doi: 10.1513/AnnalsATS.201612-1039CC. PubMed PMID: 28665709.

Laing RW, Bhogal RH, Wallace L, Boteon Y, Neil DAH, Smith A, Stephenson BTF, Schlegel A, Hübscher SG, Mirza DF, Afford SC, Mergental H. The Use of an Acellular Oxygen Carrier in a Human Liver Model of Normothermic Machine Perfusion. Transplantation. 2017 Nov;101(11):2746-2756. doi: 10.1097/TP.0000000000001821. PubMed PMID: 28520579; PubMed Central PMCID: PMC5656179

Bari S, Rabinovich M, Curry M, et al. Use of hemoglobin based oxygen carrier HBOC-021 (Hemopure) as a bridge during emergencies in patients unable to receive blood products: experience at a tertiary care center. Blood. 2017;130(Suppl 1):4926.

Taverne YJ, de Wijs-Meijler D, Te Lintel Hekkert M, et al. Normalization of hemoglobin-based oxygen carrier-201 induced vasoconstriction: targeting nitric oxide and endothelin. J Appl Physiol (1985). 2017 May 1;122(5):1227-1237. doi: 10.1152/japplphysiol.00677.2016. Epub 2017 Feb 9. PubMed PMID: 28183818.

Gomez MF, Aljure O, Ciancio G, Lynn M. Hemoglobin-Based Oxygen Carrier Rescues Double-Transplant Patient From Life-Threatening Anemia. Am J Transplant. 2017 Jul;17(7):1941-1944. doi: 10.1111/ajt.14226. Epub 2017 Mar 17. PMID:28188676

Davis JM, El-Haj N, Shah NN, Schwartz G, Block M, Wall J, Tidswell M, DiNino E. Use of the blood substitute HBOC-201 in critically ill patients during sickle crisis: a three-case series. Transfusion. 2018 Jan;58(1):132-137. doi:10.1111/trf.14386. Epub 2017 Oct 26. PubMed PMID: 29076161.

Scharman CD, Shatzel JJ, Kim E, et al. Treatment of individuals who cannot receive blood products for religious or other reasons. Am J Hematol. 2017; 92: 1370– 1381.

Gomez MF, Aljure O, Ciancio G, Lynn M. Hemoglobin-Based Oxygen Carrier Rescues Double-Transplant Patient From Life-Threatening Anemia. Am J Transplant. 2017 Jul;17(7):1941-1944. doi: 10.1111/ajt.14226. Epub 2017 Mar 17. PMID:28188676

García-Ruiz JM, Galán-Arriola C, Fernández-Jiménez R, Aguero J, Sánchez-González J, García-Alvarez A, Nuno-Ayala M, Dubé GP, Zafirelis Z, López-Martín GJ, Bernal JA, Lara-Pezzi E, Fuster V, Ibáñez B. Bloodless reperfusion with the oxygen carrier HBOC-201 in acute myocardial infarction: a novel platform for cardioprotective probes delivery. Basic Res Cardiol. 2017 Mar;112(2):17. doi: 10.1007/s00395-017-0605-6. Epub 2017 Feb 10. PubMed PMID: 28188434.

Ayyoubi MT, Manapuram S, Hashmi H, McDaniel K, Basu SK, Tse W, Krem MM. Use of a hemoglobin substitute (HBOC-201) to treat acute anemia in a leukemic patient with anti-Vel antibodies. Blood. 2017 Dec 8;130:4928.

Mer M, Hodgson E, Wallis L, Jacobson B, Levien L, Snyman J, et al. Transfusion. 2016 Oct;56(10):2631-2636. doi: 10.1111/trf.13726. Epub 2016 Sep 23. PMID:27658499

Epperla N, Strouse C, VanSandt AM, Foy P. Difficult to swallow: warm autoimmune hemolytic anemia in a Jehovah's Witness treated with hemoglobin concentrate complicated by achalasia. Transfusion. 2016 Jul;56(7):1801-6. doi: 10.1111/trf.13607. Epub 2016 Apr 6. PMID:27062564

Black V, Adamantos S, Barfield D, Tasker S. J Feline Med Surg. 2016 Aug;18(8):597-602. doi: 10.1177/1098612X15588800. Epub 2015 Jun 26. PMID:26116621

Njoku M, St Peter D, Mackenzie CF. Haemoglobin-based oxygen carriers: indications and future applications. Br J Hosp Med (Lond). 2015 Feb;76(2):78-83. doi: 10.12968/hmed.2015.76.2.78. Review. PubMed PMID: 25671471.

Holson JF, Stump DG, Pearce LB, Watson RE, DeSesso JM. Absence of developmental toxicity in a canine model after infusion of a hemoglobin-based oxygen carrier: Implications for risk assessment. Reprod Toxicol. 2015 Apr;52:101-7. doi: 10.1016/j.reprotox.2015.01.006. Epub 2015 Feb 16. PMID:25697570

Fontes P, Lopez R, van der Plaats A, Vodovotz Y, Minervini M, Scott V, et al. Liver preservation with machine perfusion and a newly developed cell-free oxygen carrier solution under subnormothermic conditions. Am J Transplant. 2015 Feb;15(2):381-94. PubMed PMID: 25612645

Raines JA, Storms T. A successful transfusion in a tamandua (Tamandua tetradactyla) using both whole blood and blood replacement products. J Zoo Wildl Med. 2015 Mar;46(1):161-3. PMID:25831593

Lundy JB, Lewis CJ, Cancio LC, Cap AP. Experience with the use of Hemopure in the care of a massively burned adult. Int J Burns Trauma. 2014 Feb 22;4(1):45-8. eCollection 2014. PMID:24624314 | PMCID:PMC3945828

Resuscitation from hemorrhagic shock using polymerized hemoglobin compared to blood. Am J Emerg Med. 2014 Mar;32(3):248-55. doi: 10.1016/j.ajem.2013.11.045. Epub 2013 Dec 7. PMID:24418449 | PMCID:PMC4049234

Van Hemelrijck J, Levien LJ, Veeckman L, Pitman A, Zafirelis Z, Standl T. A safety and efficacy evaluation of hemoglobin-based oxygen carrier HBOC-201 in a randomized, multicenter red blood cell controlled trial in noncardiac surgery patients. Anesth Analg. 2014 Oct;119(4):766-76. doi: 10.1213/ANE.0000000000000305. PMID:24977631

Rivera-Chávez FA, Lu A, Liu MM, Abdalla A, Minei JP. Hypertonic HBOC-201 decreases neutrophil activation after hemorrhagic shock. J Invest Surg. 2014 Feb;27(1):14-20. doi: 10.3109/08941939.2013.826756. PubMed PMID: 24456255.

Ortiz D, Barros M, Yan S, Cabrales P. Resuscitation from hemorrhagic shock using polymerized hemoglobin compared to blood. Am J Emerg Med. 2014 Mar;32(3):248-55. doi: 10.1016/j.ajem.2013.11.045. Epub 2013 Dec 7. PMID:24418449 | PMCID:PMC4049234

Donner MG, Topp SA, Cebula P, Krienen A, Gehrmann T, Sommerfeld A, et al.HbG200-mediated preinduction of heme oxygenase-1 improves bile flow and ameliorates pericentral downregulation of Bsep and Mrp2 following experimental liver ischemia and reperfusion. Biol Chem. 2013 Jan;394(1):97-112. doi: 10.1515/hsz-2012-0153. PMID:23096566

Jordan SD, Alexander E. Bovine hemoglobin: a nontraditional approach to the management of acute anemia in a Jehovah's Witness patient with autoimmune hemolytic anemia. J Pharm Pract. 2013 Jun;26(3):257-60. doi: 10.1177/0897190012451928. Epub 2012 Aug 6. PMID:22869910

Galvagno SM Jr, Mackenzie CF. New and future resuscitation fluids for trauma patients using hemoglobin and hypertonic saline. Anesthesiol Clin. 2013 Mar;31(1):1-19. doi: 10.1016/j.anclin.2012.10.004. Epub 2012 Dec 6. Review. PMID:23351531

Haque A, Arnaud F, Teranishi K, Okada T, Kim B, Moon-Massat PF, et al. Pre-hospital resuscitation with HBOC-201 and rFVIIa compared to HBOC-201 alone in uncontrolled hemorrhagic shock in swine. Artif Cells Blood Substit Immobil Biotechnol. 2012 Feb;40(1-2):44-55. doi: 10.3109/10731199.2011.585615. Epub 2011 Aug 2. PMID:21806503

Moon-Massat P, Scultetus A, Arnaud F, Brown A, Haque A, Saha B, et al. The effect HBOC-201 and sodium nitrite resuscitation after uncontrolled haemorrhagic shock in swine. Injury. 2012 May;43(5):638-47. doi: 10.1016/j.injury.2010.10.013. Epub 2010 Nov 20. PMID:21094491

Galvagno SM Jr, Mackenzie CF. New and future resuscitation fluids for trauma patients using hemoglobin and hypertonic saline. Anesthesiol Clin. 2013 Mar;31(1):1-19. doi: 10.1016/j.anclin.2012.10.004. Epub 2012 Dec 6. Review. PMID:23351531

Jahr JS, Akha AS, Holtby RJ. Crosslinked, polymerized, and PEG-conjugated hemoglobin-based oxygen carriers: clinical safety and efficacy of recent and current products. Curr Drug Discov Technol. 2012 Sep;9(3):158-65. Review. PMID:21745179

Teranishi K, Scultetus A, Haque A, Stern S, Philbin N, Rice J, Johnson T, et al. Traumatic brain injury and severe uncontrolled haemorrhage with short delay pre-hospital resuscitation in a swine model. Injury. 2012 May;43(5):585-93. doi: 10.1016/j.injury.2010.09.042. Epub 2010 Oct 30. PMID:21036354

Wehausen CE, Kirby R, Rudloff E. Evaluation of the effects of bovine hemoglobin glutamer-200 on systolic arterial blood pressure in hypotensive cats: 44 cases (1997-2008). J Am Vet Med Assoc. 2011 Apr 1;238(7):909-14. doi: 10.2460/javma.238.7.909. PMID:21453180

Scultetus A, Arnaud F, Kaplan L, Shander A, Philbin N, Rice J, McCarron R, et al. Hemoglobin-based oxygen carrier (HBOC-201) and escalating doses of recombinant factor VIIa (rFVIIa) as a novel pre-hospital resuscitation fluid in a swine model of severe uncontrolled hemorrhage. Artif Cells Blood Substit Immobil Biotechnol. 2011 Apr;39(2):59-68. Epub 2010 Jul 20. PMID:20645681

Muir WW, Ilangovan G, Zweier JL, Moon-Massat PF, Rentko VT. Vital organ tissue oxygenation after serial normovolemic exchange transfusion with HBOC-201 in anesthetized swine. Shock 2011 Jun;35(6):597-603. doi: 10.1097/SHK.0b013e31821366f6. PMID:21330945 | PMCID:PMC3221463

Arnaud F, McCarron R, Freilich D. Amylase and lipase detection in hemorrhaged animals treated with HBOC-201.
Artif Cells Blood Substit Immobil Biotechnol. 2011 Jun;39(3):155-61. doi: 10.3109/10731199.2010.516260. Epub 2010 Dec 21. PMID:21171938

McNeil JD, Propper B, Walker J, Holguin L, Evans L, Lee K, et al. A bovine hemoglobin-based oxygen carrier as pump prime for cardiopulmonary bypass: reduced systemic lactic acidosis and improved cerebral oxygen metabolism during low flow in a porcine model. J Thorac Cardiovasc Surg. 2011 Aug;142(2):411-7. doi: 10.1016/j.jtcvs.2010.11.017. PMID:21641005

Minei JP. Is there a role for hemopure in the prehospital setting? J Trauma. 2011 May;70(5 Suppl):S38-9. doi: 10.1097/TA.0b013e31821a5a09. Review. No abstract available. PMID:21841569

Vázquez BY, Hightower CM, Martini J, Messmer C, Frienesenecker B, Corbels P, et al. Vasoactive hemoglobin solution improves survival in hemodilution followed by hemorrhagic shock. Crit Care Med. 2011 Jun;39(6):1461-6. doi: 10.1097/CCM.0b013e3182120cdb. PMID:21336111 | PMCID:PMC3318980

Fitzgerald MC, Chan JY, Ross AW, Liew SM, Butt WW, Baguley D, Salem HH, Russ MK, Deasy C, Martin KE, Mathew JK, Rosenfeld JV. A synthetic haemoglobin-based oxygen carrier and the reversal of cardiac hypoxia secondary to severe anaemia following trauma. Med J Aust. 2011 May 2;194(9):471-3. PMID:21534906

Jahr JS, Liu H, Albert OK, Gull A, Moallempour M, Lim J, Gosselin R. Does HBOC-201 (Hemopure) affect platelet function in orthopedic surgery: a single-site analysis from a multicenter study. Am J Ther. 2010 Mar-Apr;17(2):140-7. doi: 10.1097/MJT.0b013e3181a2b08d. PMID:19417588

Marinaro J, Smith J, Tawil I, Billstrand M, Crookston KP. HBOC-201 use in traumatic brain injury: case report and review of literature. Transfusion. 2009 Oct;49(10):2054-9. doi: 10.1111/j.1537-2995.2009.02235.x. Epub 2009 May 27. Review. PMID:19497051

Te Lintel Hekkert M, Dubé GP, Regar E, de Boer M, Vranckx P, van der Giessen WJ, Serruys PW, Duncker DJ.
Preoxygenated hemoglobin-based oxygen carrier HBOC-201 annihilates myocardial ischemia during brief coronary artery occlusion in pigs. Am J Physiol Heart Circ Physiol. 2010 Mar;298(3):H1103-13. doi: 10.1152/ajpheart.00667.2009. Epub 2010 Jan 8. PMID:20061545

Greenburg AG, Light WR, Dubé GP. Reconstructing hemoglobin-based oxygen carriers. Transfusion. 2010 Dec;50(12):2764-7; author reply 2767. doi: 10.1111/j.1537-2995.2010.02814.x. No abstract available. PMID:21126254

Katz LM, Manning JE, McCurdy S, Sproule C, McGwin G Jr, Moon-Massat P, et al. Nitroglycerin attenuates vasoconstriction of HBOC-201 during hemorrhagic shock resuscitation. Resuscitation. 2010 Apr;81(4):481-7. doi: 10.1016/j.resuscitation.2009.12.015. Epub 2010 Jan 18. PMID:20080328

Mackenzie CF, Moon-Massat PF, Shander A, Javidroozi M, Greenburg AG.
When blood is not an option: factors affecting survival after the use of a hemoglobin-based oxygen carrier in 54 patients with life-threatening anemia. Anesth Analg. 2010 Mar 1;110(3):685-93. doi: 10.1213/ANE.0b013e3181cd473b. PMID:20042443

Donahue LL, Shapira I, Shander A, Kolitz J, Allen S, Greenburg G. Management of acute anemia in a Jehovah's Witness patient with acute lymphoblastic leukemia with polymerized bovine hemoglobin-based oxygen carrier: a case report and review of literature. Transfusion. 2010 Jul;50(7):1561-7. doi: 10.1111/j.1537-2995.2010.02603.x. Epub 2010 Apr 23. Review. PMID:20456679

Weiskopf RB. Hemoglobin-based oxygen carriers: compassionate use and compassionate clinical trials. Anesth Analg. 2010 Mar 1;110(3):659-62. doi: 10.1213/ANE.0b013e3181c85255. No abstract available. PMID:20185643

Muller CF. Blood alternative products: correction regarding Jehovah's Witnesses. S Afr Med J. 2009 Feb;99(2):72, 74; author reply 74. No abstract available. PMID:19422107

Stern S, Rice J, Philbin N, McGwin G, Arnaud F, Johnson T, et al. Resuscitation with the hemoglobin-based oxygen carrier, HBOC-201, in a swine model of severe uncontrolled hemorrhage and traumatic brain injury. Shock. 2009 Jan;31(1):64-79. doi: 10.1097/SHK.0b013e3181778dc3. PMID:18497706

Freilich D, Pearce LB, Pitman A, Greenburg G, Berzins M, Bebris L, et al. HBOC-201 vasoactivity in a phase III clinical trial in orthopedic surgery subjects--extrapolation of potential risk for acute trauma trials. J Trauma. 2009 Feb;66(2):365-76. doi: 10.1097/TA.0b013e3181820d5c. PMID:19204509

Zapletal C, Bode A, Lorenz MW, Gebhard MM, Golling M. Effects of hemodilution with a hemoglobin-based oxygen carrier (HBOC-201) on ischemia/reperfusion injury in a model of partial warm liver ischemia of the rat. Microvasc Res. 2009 Dec;78(3):386-92. doi: 10.1016/j.mvr.2009.08.005. Epub 2009 Aug 26. PMID:19715706

Moallempour M, Jahr JS, Lim JC, Weeks D, Butch A, Driessen B. Methemoglobin effects on coagulation: a dose-response study with HBOC-200 (Oxyglobin) in a thrombelastogram model. J Cardiothorac Vasc Anesth. 2009 Feb;23(1):41-7. doi: 10.1053/j.jvca.2008.06.006. Epub 2008 Aug 29. PMID:18834828

Rodriguez C, Vitturi DA, He J, Vandromme M, Brandon A, Hutchings A, Rue LW 3rd, Kerby JD, Patel RP. Sodium nitrite therapy attenuates the hypertensive effects of HBOC-201 via nitrite reduction. Biochem J. 2009 Aug 27;422(3):423-32. doi: 10.1042/BJ20090735. PMID:19555351 | PMCID:PMC2775055

Singleton CL, Oosterhuis JE, Seibold K, Lamberski N. Successful treatment of a southern Pacific rattlesnake (Crotalus viridis helleri) bite in a caracal (Caracal caracal). J Zoo Wildl Med. 2009 Jun;40(2):378-81. PMID:19569491

Zambelli AB, Leisewitz AL. A prospective, randomized comparison of Oxyglobin (HB-200) and packed red blood cell transfusion for canine babesiosis. J Vet Emerg Crit Care (San Antonio). 2009 Feb;19(1):102-12. doi: 10.1111/j.1476-4431.2009.00386.x. PMID:19691591

Mongan PD, Moon-Massat PF, Rentko V, Mihok S, Dragovich A, Sharma P. Regional blood flow after serial normovolemic exchange transfusion with HBOC-201 (Hemopure) in anesthetized swine. J Trauma. 2009 Jul;67(1):51-60. doi: 10.1097/TA.0b013e3181838030. PMID:19590308

Rempf C, Standl T, Schenke K, Chammas K, Gottschalk A, Burmeister MA, et al. Administration of bovine polymerized haemoglobin before and during coronary occlusion reduces infarct size in rabbits. Br J Anaesth. 2009 Oct;103(4):496-504. doi: 10.1093/bja/aep233. Epub 2009 Aug 26. PMID:19710071

Yu B, Volpato GP, Chang K, Bloch KD, Zapol WM. Prevention of the pulmonary vasoconstrictor effects of HBOC-201 in awake lambs by continuously breathing nitric oxide. Anesthesiology. 2009 Jan;110(1):113-22. doi: 10.1097/ALN.0b013e318190bc4f. PMID:19104178 | PMCID:PMC2704389

Jahr J. Do approved blood substitutes reduce myocardial infarction size: is this the critical question? Br J Anaesth. 2009 Oct;103(4):470-1. doi: 10.1093/bja/aep227. No abstract available. PMID:19749116

Mackenzie CF. Haemoglobin-based oxygen carriers: is the benefit worth the risk? Br J Hosp Med (Lond). 2009 Jan;70(1):26-30. PMID:19357574

Lichtenberger M, Orcutt C, Cray C, Thamm DH, DeBehnke D, Page C, et al. Comparison of fluid types for resuscitation after acute blood loss in mallard ducks (Anas platyrhynchos). J Vet Emerg Crit Care (San Antonio). 2009 Oct;19(5):467-72. doi: 10.1111/j.1476-4431.2009.00465.x. PMID:19821888

HE Potgieter & MF James (2009) The use of Hemopure® at Groote Schuur hospital, Cape Town: 4 case studies, Southern African Journal of Anaesthesia and Analgesia, 15:1, 13-15, DOI: 10.1080/22201173.2009.10872581

HE Potgieter & MF James (2009) The use of Hemopure® at Groote Schuur hospital, Cape Town: 4 case studies, Southern African Journal of Anaesthesia and Analgesia, 15:1, 13-15, DOI: 10.1080/22201173.2009.10872581

Arnaud F, Hammett M, Philbin N, Scultetus A, McCarron R, Freilich D. Hematologic effects of recombinant factor VIIa combined with hemoglobin-based oxygen carrier-201 for prehospital resuscitation of swine with severe uncontrolled hemorrhage due to liver injury. Blood Coagul Fibrinolysis. 2008 Oct;19(7):669-77. doi: 10.1097/MBC.0b013e3283089198. PMID:18832908

Dubé GP, Vranckx P, Greenburg AG. HBOC-201: the multi-purpose oxygen therapeutic. EuroIntervention. 2008 May;4(1):161-5. Review. PMID:19112795

Jahr JS, Mackenzie C, Pearce LB, Pitman A, Greenburg AG. HBOC-201 as an alternative to blood transfusion: efficacy and safety evaluation in a multicenter phase III trial in elective orthopedic surgery. J Trauma. 2008 Jun;64(6):1484-97. doi:

Topp SA, Krieg A, Koch A, Tidden CM, Ramp U, Hohlfeld T, et al. Hemoglobin-glutamer 200 reduces reperfusion injury of the cold preserved rat liver by induction of heme oxygenase-1. J Surg Res. 2008 Dec;150(2):243-54. doi: 10.1016/j.jss.2008.02.033. Epub 2008 Mar 18. PMID:18395753

Pachinburavan M, Marik PE. Bovine blood and neuromuscular paralysis as a bridge to recovery in a patient with severe autoimmune hemolytic anemia. Clin Transl Sci. 2008 Sep;1(2):172-3. doi: 10.1111/j.1752-8062.2008.00006.x. PMID:20443842 | PMCID:PMC5439555

Jahr JS, Moallempour M, Lim JC. HBOC-201, hemoglobin glutamer-250 (bovine), Hemopure (Biopure Corporation). Expert Opin Biol Ther. 2008 Sep;8(9):1425-33. doi: 10.1517/14712598.8.9.1425 . Review. PMID:18694360

Dudkiewicz M, Harpaul TA, Proctor KG. Hemoglobin-based oxygen carrying compound-201 as salvage therapy for severe neuro- and polytrauma (Injury Severity Score = 27-41). Crit Care Med. 2008 Oct;36(10):2838-48. doi: 10.1097/CCM.0b013e318186f6b3. PMID:18766094

Bateman C. Metanalysis critical of blood alternative product challenged. S Afr Med J. 2008 Oct;98(10):746, 748. No abstract available. PMID:19115744

Rosenthal G, Morabito D, Cohen M, Roeytenberg A, Derugin N, Panter SS, et al. Use of hemoglobin-based oxygen-carrying solution-201 to improve resuscitation parameters and prevent secondary brain injury in a swine model of traumatic brain injury and hemorrhage: laboratory investigation. J Neurosurg. 2008 Mar;108(3):575-87. doi: 10.3171/JNS/2008/108/3/0575. PMID:18312106

Mackenzie CF, Morrison C, Jaberi M, Genuit T, Katamuluwa S, Rodriguez A. Management of hemorrhagic shock when blood is not an option. J Clin Anesth. 2008 Nov;20(7):538-41. doi: 10.1016/j.jclinane.2008.05.012. Epub 2008 Nov 18. PMID:19019664

Weingart C, Kohn B. Clinical use of a haemoglobin-based oxygen carrying solution (Oxyglobin) in 48 cats (2002-2006). J Feline Med Surg. 2008 Oct;10(5):431-8. doi: 10.1016/j.jfms.2007.10.012. Epub 2008 May 2. PMID:18455461

Jahr JS, Lurie F, Bezdikian V, Driessen B, Gunther RA. Measuring circulating blood volume using infused hemoglobin-based oxygen carrier (oxyglobin) as an indicator: verification in a canine hypovolemia model. Am J Ther. 2008 Mar-Apr;15(2):98-101. doi: 10.1097/MJT.0b013e31804c6f98. PMID:18356627

Kocian R, Spahn DR. Haemoglobin, oxygen carriers and perioperative organ perfusion. Best Pract Res Clin Anaesthesiol. 2008 Mar;22(1):63-80. Review. PMID:18494389

Meliga E, Vranckx P, Regar E, Kint PP, Duncker DJ, Serruys PW. Proof-of-concept trial to evaluate haemoglobin based oxygen therapeutics in elective percutaneous coronary revascularisation. Rationale, protocol design and haemodynamic results. EuroIntervention. 2008 May;4(1):99-107. PMID:19112786

Harris DR, Palmer AF. Modern cross-linking strategies for synthesizing acellular hemoglobin-based oxygen carriers. Biotechnol Prog. 2008 Nov-Dec;24(6):1215-25. doi: 10.1002/btpr.85. Review. PMID:19194934 | PMCID:PMC2637476

Gundersen SI, Palmer AF. Hemoglobin-based oxygen carrier enhanced tumor oxygenation: a novel strategy for cancer therapy. Biotechnol Prog. 2008 Nov-Dec;24(6):1353-64. doi: 10.1002/btpr.56. PMID:19194950

Serruys PW, Vranckx P, Slagboom T, Regar E, Meliga E, de Winter RJ, et al. Haemodynamic effects, safety, and tolerability of haemoglobin-based oxygen carrier-201 in patients undergoing PCI for CAD. EuroIntervention. 2008 Mar;3(5):600-9. PMID:19608488

Malkevich NV, Dong F, Vandermolen CA, Philbin NB, Rice JP, Scultetus A, et al. Innate immune response after resuscitation with hemoglobin-based oxygen carrier and recombinant factor VIIA in uncontrolled hemorrhagic shock in a swine model. J Trauma. 2008 Jun;64(6):1498-510. doi: 10.1097/TA.0b013e3181454a05. PMID:18545114

ahr JS, Walker V, Manoochehri K. Blood substitutes as pharmacotherapies in clinical practice. Curr Opin Anaesthesiol. 2007 Aug;20(4):325-30. Review. PMID:17620840

Driessen B, Zarucco L, Gunther RA, Burns PM, Lamb SV, Vincent SE, et al. Effects of low-volume hemoglobin glutamer-200 versus normal saline and arginine vasopressin resuscitation on systemic and skeletal muscle blood flow and oxygenation in a canine hemorrhagic shock model. Crit Care Med. 2007 Sep;35(9):2101-9. PMID:17581486

Kerby JD, Sainz JG, Zhang F, Hutchings A, Sprague S, Farrokhi FR, et al. Resuscitation from hemorrhagic shock with HBOC-201 in the setting of traumatic brain injury. Shock. 2007 Jun;27(6):652-6. PMID:17505305

Rivera-Chavez FA, Huerta S, Brown R, York GB, Minei JP. Resuscitation from hemorrhagic shock comparing standard hemoglobin-based oxygen carrier (HBOC)-201 versus 7.5% hypertonic HBOC-201. J Trauma. 2007 Nov;63(5):1113-9. PMID:17993959

Philbin N, Handrigan M, Rice J, McNickle K, McGwin G, Williams R, et al. Resuscitation following severe, controlled hemorrhage associated with a 24 h delay to surgical intervention in swine using a hemoglobin based oxygen carrier as an oxygen bridge to definitive care. Resuscitation. 2007 Aug;74(2):332-43. Epub 2007 Mar 23. PMID:17383073

Henkel-Honke T, Oleck M. Artificial oxygen carriers: a current review. AANA J. 2007 Jun;75(3):205-11. Review. PMID:17591302

Dimino ML, Palmer AF. Hemoglobin-based O2 carrier O2 affinity and capillary inlet pO2 are important factors that influence O2 transport in a capillary. Biotechnol Prog. 2007 Jul-Aug;23(4):921-31. Epub 2007 Jun 8. PMID:17555329 | PMCID:PMC2533853

Stefan DC, Uys R, Wessels G. Hemopure transfusion in a child with severe anemia. Pediatr Hematol Oncol. 2007 Jun;24(4):269-73. PMID:17613869.

Hamilton RG, Kickler TS. Bovine hemoglobin (glutamer-250, Hemopure)-specific immunoglobulin G antibody cross-reacts with human hemoglobin but does not lyse red blood cells in vitro. Transfusion. 2007 Apr;47(4):723-8. PMID:17381632

Ashenden MJ, Schumacher YO, Sharpe K, Varlet-Marie E, Audran M. Effects of Hemopure on maximal oxygen uptake and endurance performance in healthy humans. Int J Sports Med. 2007 May;28(5):381-5. Epub 2006 Oct 6. PMID:17024639

VanderMolen C, Malkevich N, Philbin N, Rice J, Collier S, Hall C, et al. Immune effects of decreasing low-molecular weight hemoglobin components of hemoglobin-based oxygen carriers (HBOC) in a swine model of severe controlled hemorrhagic shock. Artif Cells Blood Substit Immobil Biotechnol. 2007;35(5):507-17. PMID:17922315

Arnaud F, Fasipe D, Philbin N, Rice J, Flournoy WS, Ahlers S, et al. Hematology patterns after hemoglobin-based oxygen carrier resuscitation from severe controlled hemorrhage with prolonged delayed definitive care. Transfusion. 2007 Nov;47(11):2098-109. PMID:17958540

Hall C, Malkevich N, Handrigan M, Vandermolen C, Aranaud F, Hong J, et al. Innate immune responses in Swine resuscitated from severe traumatic hemorrhagic shock with hemoglobin-based oxygen carrier-201. Artif Cells Blood Substit Immobil Biotechnol. 2007;35(3):259-74. PMID:17573626

Philbin N, Handrigan M, Rice J, McNickle K, McGwin G, Williams R, et al. Resuscitation following severe, controlled hemorrhage associated with a 24 h delay to surgical intervention in swine using a hemoglobin based oxygen carrier as an oxygen bridge to definitive care. Resuscitation. 2007 Aug;74(2):332-43. Epub 2007 Mar 23. PMID:17383073

Freitag M, Standl TG, Kleinhans H, Gottschalk A, Mann O, Rempf C, Bachmann K, Gocht A, Petri S, Izbicki JR, Strate T. Improvement of impaired microcirculation and tissue oxygenation by hemodilution with hydroxyethyl starch plus cell-free hemoglobin in acute porcine pancreatitis. Pancreatology. 2006;6(3):232-9. Epub 2006 Mar 9. PMID:16534248

Ortegon DP, Davis MR, Sampson JB, Dick EJ, Kashyap V, Kerby JD. Bovine hemoglobin-based oxygen-carrying solution (HBOC-201) improves flap survival in a rat model of epigastric flap failure. Microsurgery. 2006;26(3):203-6. PMID:16493668

Baylis C. Acute and long-term effects of modified hemoglobin (HBOC-201) in a rat model of hypertension and chronic kidney disease. Transfusion. 2006 Jul;46(7):1104-11. PMID:16836556

Dong F, Hall CH, Golech SA, Philbin NB, Rice JP, Gurney J, et al. Immune effects of resuscitation with HBOC-201, a hemoglobin-based oxygen carrier, in swine with moderately severe hemorrhagic shock from controlled hemorrhage. Shock. 2006 Jan;25(1):50-5. PMID:16369186

Driessen B, Jahr JS, Lurie F, Gunther RA.
Effects of isovolemic resuscitation with hemoglobin-based oxygen carrier Hemoglobin glutamer-200 (bovine) on systemic and mesenteric perfusion and oxygenation in a canine model of hemorrhagic shock: a comparison with 6% hetastarch solution and shed blood. Vet Anaesth Analg. 2006 Nov;33(6):368-80. PMID:17083609

treatment of severe acute experimental pancreatitis using free cellular hemoglobin. World J Gastroenterol. 2006 May 14;12(18):2914-8. PMID:16718818 | PMCID:PMC4087810

Patel MB, Feinstein AJ, Saenz AD, Majetschak M, Proctor KG. Prehospital HBOC-201 after traumatic brain injury and hemorrhagic shock in swine. J Trauma. 2006 Jul;61(1):46-56. PMID:16832248

Rice J, Philbin N, McGwin G, Arnaud F, Johnson T, Flournoy WS, et al. Bovine polymerized hemoglobin versus Hextend resuscitation in a swine model of severe controlled hemorrhagic shock with delay to definitive care. Shock. 2006 Sep;26(3):302-10. PMID:16912657

Johnson T, Arnaud F, Dong F, Philbin N, Rice J, Asher L, et al. Bovine polymerized hemoglobin (hemoglobin-based oxygen carrier-201) resuscitation in three swine models of hemorrhagic shock with militarily relevant delayed evacuation--effects on histopathology and organ function. Crit Care Med. 2006 May;34(5):1464-74. PMID:16540964

George I, Yi GH, Schulman AR, Morrow BT, Cheng Y, Gu A, et al. A polymerized bovine hemoglobin oxygen carrier preserves regional myocardial function and reduces infarct size after acute myocardial ischemia. Am J Physiol Heart Circ Physiol. 2006 Sep;291(3):H1126-37. Epub 2006 Apr 14. PMID:16617139

Bonegio RG, Fuhro R, Ragno G, Robert Valeri C, Lieberthal W. A comparison of the acute hemodynamic and delayed effects of 50% exchange transfusion with two different cross-linked hemoglobin based oxygen carrying solutions and Pentastarch. Artif Cells Blood Substit Immobil Biotechnol. 2006;34(2):145-57. PMID:16537171

Cheung AT, Duong PL, Driessen B, Chen PC, Jahr JS, Gunther RA. Systemic function, oxygenation and microvascular correlation during treatment of hemorrhagic shock with blood substitutes. Clin Hemorheol Microcirc. 2006;34(1-2):325-34. PMID:16543653

Arnaud F, Handrigan M, Hammett M, Philbin N, Rice J, Dong F, et al. Coagulation patterns following haemoglobin-based oxygen carrier resuscitation in severe uncontrolled haemorrhagic shock in swine. Transfus Med. 2006 Aug;16(4):290-302. PMID:16879158

Soma LR, Uboh CE, Guan F, Luo Y, Moate PJ, Boston RC, Driessen B. The pharmacokinetics of hemoglobin-based oxygen carrier hemoglobin glutamer-200 bovine in the horse. Anesth Analg. 2005 Jun;100(6):1570-5. PMID:15920176

Caswell JE, Strange MB, Rimmer DM 3rd, Gibson MF, Cole P, Lefer DJ. A novel hemoglobin-based blood substitute protects against myocardial reperfusion injury. Am J Physiol Heart Circ Physiol. 2005 Apr;288(4):H1796-801. PMID:15772335

Fitzpatrick CM, Biggs KL, Atkins BZ, Quance-Fitch FJ, Dixon PS, Savage SA, et al. Prolonged low-volume resuscitation with HBOC-201 in a large-animal survival model of controlled hemorrhage. J Trauma. 2005 Aug;59(2):273-81; discussion 281-3. PMID:16294065

Agrawal YP, Freedman M, Szczepiorkowski ZM. Long-term transfusion of polymerized bovine hemoglobin in a Jehovah's Witness following chemotherapy for myeloid leukemia: a case report. Transfusion. 2005 Nov;45(11):1735-8. PMID:16271098

Burkhoff D, Lefer DJ. Cardioprotection before revascularization in ischemic myocardial injury and the potential role of hemoglobin-based oxygen carriers. Am Heart J. 2005 Apr;149(4):573-9. Review. PMID:15990736

Laccetti A, Bagai J, Gawryl MS, Light WR. Hemopure's process demonstrates TSE and viral clearance. Dev Biol (Basel). 2005;120:35-6. No abstract available. PMID:16050153

Strate T, Mann O, Kleinhans H, Rusani S, Schneider C, Yekebas E, Freitag M, Standl T, Bloechle C, Izbicki JR. Microcirculatory function and tissue damage is improved after therapeutic injection of bovine hemoglobin in severe acute rodent pancreatitis. Pancreas. 2005 Apr;30(3):254-9. PMID:15782104

Arnaud F, Hammett M, Asher L, Philbin N, Rice J, Dong F, et al. Effects of bovine polymerized hemoglobin on coagulation in controlled hemorrhagic shock in swine. Shock. 2005 Aug;24(2):145-52. PMID:16044085

Burmeister MA, Rempf C, Standl TG, Rehberg S, Bartsch-Zwemke S, Krause T, et al.
Effects of prophylactic or therapeutic application of bovine haemoglobin HBOC-200 on ischaemia-reperfusion injury following acute coronary ligature in rats. Br J Anaesth. 2005 Dec;95(6):737-45. Epub 2005 Oct 14. PMID:16227339

King DR, Cohn SM, Proctor KG. Resuscitation with a hemoglobin-based oxygen carrier after traumatic brain injury. J Trauma. 2005 Sep;59(3):553-60; discussion 560-2. PMID:16361895

Buehler PW, Boykins RA, Jia Y, Norris S, Freedberg DI, Alayash AI. Structural and functional characterization of glutaraldehyde-polymerized bovine hemoglobin and its isolated fractions. Anal Chem. 2005 Jun 1;77(11):3466-78. PMID:15924377

Gasthuys M, Alves S, Tabet JC. N-terminal adducts of bovine hemoglobin with glutaraldehyde in a hemoglobin-based oxygen carrier. Anal Chem. 2005 May 15;77(10):3372-8. PMID:15889931

Freitag M, Standl TG, Gottschalk A, Burmeister MA, Rempf C, Horn EP, et al. Enhanced central organ oxygenation after application of bovine cell-free hemoglobin HBOC-201. Can J Anaesth. 2005 Nov;52(9):904-14. PMID:16251554

Gottschalk A, Raabe A, Hommel M, Rempf C, Freitag M, Standl T. Influence of the hemoglobin solution HBOC-201 on tissue oxygenation in the rat R1H-tumor. Artif Cells Blood Substit Immobil Biotechnol. 2005;33(4):379-89. PMID:16317957

Philbin N, Rice J, Gurney J, McGwin G, Arnaud F, Dong F, et al. A hemoglobin-based oxygen carrier, bovine polymerized hemoglobin (HBOC-201) versus hetastarch (HEX) in a moderate severity hemorrhagic shock swine model with delayed evacuation. Resuscitation. 2005 Sep;66(3):367-78. PMID:16081200

Marret E, Bonnin P, Mazoyer E, Riou B, Jacobs T, Coriat P, Samama CM. The effects of a polymerized bovine-derived hemoglobin solution in a rabbit model of arterial thrombosis and bleeding. Anesth Analg. 2004 Mar;98(3):604-10, table of contents. PMID:14980905

Anbari KK, Garino JP, Mackenzie CF. Hemoglobin substitutes. Eur Spine J. 2004 Oct;13 Suppl 1:S76-82. Epub 2004 May 27. Review. PMID:15168238 | PMCID:PMC3592184

Greenburg AG, Kim HW. Hemoglobin-based oxygen carriers. Crit Care. 2004;8 Suppl 2:S61-4. Epub 2004 Jun 14. Review. PMID:15196328 | PMCID:PMC3226150

James MF, Potgieter HE, Ellis P. The effect of hemopure on coagulation in clinically relevant concentrations. Anesth Analg. 2004 Dec;99(6):1593-7, table of contents. PMID:15562038

Bateman C. Hope for reducing SA's trauma deaths? S Afr Med J. 2004 Sep;94(9):728-9. No abstract available. PMID:15487829

Henderson CL, Anderson CM, Sorrells DL, Wilson BJ, Dick EJ, DiGeronimo RJ. The use of a hemoglobin-based oxygen-carrying solution (HBOC-201) for extracorporeal membrane oxygenation in a porcine model with acute respiratory distress syndrome. Pediatr Crit Care Med. 2004 Jul;5(4):384-90. PMID:15215011

Guan F, Uboh CE, Soma LR, Luo Y, Jahr JS, Driessen B.
Confirmation and quantification of hemoglobin-based oxygen carriers in equine and human plasma by hyphenated liquid chromatography tandem mass spectrometry Anal Chem. 2004 Sep 1;76(17):5127-35. PMID:15373452

Varlet-Marie E, Ashenden M, Lasne F, Sicart MT, Marion B, de Ceaurriz J, Audran M.
Detection of hemoglobin-based oxygen carriers in human serum for doping analysis: confirmation by size-exclusion HPLC. Clin Chem. 2004 Apr;50(4):723-31. Epub 2004 Feb 5. PMID:14764640

Lichtenberger M. Transfusion medicine in exotic pets. Clin Tech Small Anim Pract. 2004 May;19(2):88-95. Review. PMID:15179929

Marret E, Bonnin P, Mazoyer E, Riou B, Jacobs T, Coriat P, Samama CM. The effects of a polymerized bovine-derived hemoglobin solution in a rabbit model of arterial thrombosis and bleeding. Anesth Analg. 2004 Mar;98(3):604-10, table of contents. PMID:14980905

Fitzpatrick CM, Savage SA, Kerby JD, Clouse WD, Kashyap VS. Resuscitation with a blood substitute causes vasoconstriction without nitric oxide scavenging in a model of arterial hemorrhage. J Am Coll Surg. 2004 Nov;199(5):693-701. PMID:15501108

Lasne F, Crepin N, Ashenden M, Audran M, de Ceaurriz J.
Detection of hemoglobin-based oxygen carriers in human serum for doping analysis: screening by electrophoresis. Clin Chem. 2004 Feb;50(2):410-5. Epub 2003 Nov 21. PMID:14633908

Knudson MM, Lee S, Erickson V, Morabito D, Derugin N, Manley GT. Tissue oxygen monitoring during hemorrhagic shock and resuscitation: a comparison of lactated Ringer's solution, hypertonic saline dextran, and HBOC-201. J Trauma. 2003 Feb;54(2):242-52. PMID:12579047

Standl T, Freitag M, Burmeister MA, Horn EP, Wilhelm S, Am Esch JS. Hemoglobin-based oxygen carrier HBOC-201 provides higher and faster increase in oxygen tension in skeletal muscle of anemic dogs than do stored red blood cells. J Vasc Surg. 2003 Apr;37(4):859-65. PMID:12663989

Levy JH. The use of haemoglobin glutamer-250 (HBOC-201) as an oxygen bridge in patients with acute anaemia associated with surgical blood loss. Expert Opin Biol Ther. 2003 Jun;3(3):509-17. Review. Erratum in: Expert Opin Biol Ther. 2003 Sep;3(6):1017. PMID:12783619

Ortegon DP, Dixon PS, Crow KK, Mueller DL, Kerby JD. The effect of the bovine hemoglobin oxygen therapeutic HBOC-201 on human neutrophil activation in vitro. J Trauma. 2003 Oct;55(4):755-60; discussion 760-1. PMID:14566134

Manley GT, Hemphill JC, Morabito D, Erickson V, Holcroft JJ, Derugin N, Knudson MM. Small-volume resuscitation with the hemoglobin substitute HBOC-201: effect on brain tissue oxygenation. Adv Exp Med Biol. 2003;530:311-7. PMID:14562727

Callan MB, Rentko VT. Clinical application of a hemoglobin-based oxygen-carrying solution. Vet Clin North Am Small Anim Pract. 2003 Nov;33(6):1277-93, vi. Review. PMID:14664199

Driessen B, Jahr JS, Lurie F, Golkaryeh MS, Gunther RA. Arterial oxygenation and oxygen delivery after hemoglobin-based oxygen carrier infusion in canine hypovolemic shock: a dose-response study. Crit Care Med. 2003 Jun;31(6):1771-9. PMID:12794419

Lurie F, Driessen B, Jahr JS, Reynoso R, Gunther RA. Validity of arterial and mixed venous oxygen saturation measurements in a canine hemorrhage model after resuscitation with varying concentrations of hemoglobin-based oxygen carrier. Anesth Analg. 2003 Jan;96(1):46-50, table of contents. PMID:12505921

Posner LP, Moon PF, Bliss SP, Gleed RD, Erb HN.
Colloid osmotic pressure after hemorrhage and replenishment with Oxyglobin Solution, hetastarch, or whole blood in pregnant sheep. Vet Anaesth Analg. 2003 Jan;30(1):30-6. PMID:14498915

Strate T, Mann O, Kleinhans H, Schneider C, Knoefel WT, Yekebas E, et al. Systemic intravenous infusion of bovine hemoglobin significantly reduces microcirculatory dysfunction in experimentally induced pancreatitis in the rat. Ann Surg. 2003 Nov;238(5):765-71. PMID:14578741 | PMCID:PMC1356157

Jahr JS, Lurie F, Driessen B, Tang Z, Louie RF, Kost G. Validation of oxygen saturation measurements in a canine model of hemoglobin-based oxygen carrier infusion. Am J Ther. 2003 Jan-Feb;10(1):21-8. PMID:12522516

Pearce LB, Gawryl MS. The pharmacology of tissue oxygenation by biopure's hemoglobin-based oxygen carrier, Hemopure (HBOC-201). Adv Exp Med Biol. 2003;530:261-70. PMID:14562723

Khan AK, Jahr JS, Nesargi S, Rothenberg SJ, Tang Z, Cheung A, et al. Does lead interfere with hemoglobin-based oxygen carrier (HBOC) function? A pilot study of lead concentrations in three approved or tested HBOCs and oxyhemoglobin dissociation with HBOCs and/or bovine blood with varying lead concentrations. Anesth Analg. 2003 Jun;96(6):1813-20, table of contents. PMID:12761018

Sampson JB, Davis MR, Mueller DL, Kashyap VS, Jenkins DH, Kerby JD. A comparison of the hemoglobin-based oxygen carrier HBOC-201 to other low-volume resuscitation fluids in a model of controlled hemorrhagic shock. J Trauma. 2003 Oct;55(4):747-54. PMID:14566133

York GB, Eggers JS, Smith DL, Jenkins DH, McNeil JD, Mueller D, et al. Low-volume resuscitation with a polymerized bovine hemoglobin-based oxygen-carrying solution (HBOC-201) provides adequate tissue oxygenation for survival in a porcine model of controlled hemorrhage. J Trauma. 2003 Nov;55(5):873-85. PMID:14608160

York GB, DiGeronimo RJ, Wilson BJ, Cofer BR, Breuer CK, Josephs JD, et al. Extracorporeal membrane oxygenation in piglets using a polymerized bovine hemoglobin-based oxygen-carrying solution (HBOC-201). J Pediatr Surg. 2002 Oct;37(10):1387-92. PMID:12378440

Jahr JS, Lurie F, Driessen B, Davis JA, Gosselin R, Gunther RA. The HemoCue, a point of care B-hemoglobin photometer, measures hemoglobin concentrations accurately when mixed in vitro with canine plasma and three hemoglobin-based oxygen carriers (HBOC). Can J Anaesth. 2002 Mar;49(3):243-8. PMID:11861341

Gannon CJ, Napolitano LM. Severe anemia after gastrointestinal hemorrhage in a Jehovah's Witness: new treatment strategies. Crit Care Med. 2002 Aug;30(8):1893-5. PMID:12163811

Dorman SC, Kenny CF, Miller L, Hirsch RE, Harrington JP. Role of redox potential of hemoglobin-based oxygen carriers on methemoglobin reduction by plasma components. Artif Cells Blood Substit Immobil Biotechnol. 2002 Jan;30(1):39-51. PMID:12000225

Lee SK, Morabito D, Hemphill JC, Erickson V, Holcroft JJ, Derugin N, et al. Small-volume resuscitation with HBOC-201: effects on cardiovascular parameters and brain tissue oxygen tension in an out-of-hospital model of hemorrhage in swine. Acad Emerg Med. 2002 Oct;9(10):969-76. PMID:12359531

Jahr JS, Lurie F, Gosselin R, Lin JS, Wong L, Owings JT, Larkin E. Effects of hemoglobin glutamer-250 (bovine) (HBOC-201, Hemopure) on coagulation testing. Am J Ther. 2002 Sep-Oct;9(5):431-6. PMID:12237736

Katz LM, Manning JE, McCurdy S, Pearce LB, Gawryl MS, Wang Y, Brown C; Carolina Resuscitation Research Group. HBOC-201 improves survival in a swine model of hemorrhagic shock and liver injury. Resuscitation. 2002 Jul;54(1):77-87. PMID:12104112

Ortegon DP, Davis MR, Dixon PS, Smith DL, Josephs JD, Mueller DL, et al. The polymerized bovine hemoglobin-based oxygen-carrying solution (HBOC-201) is not toxic to neural cells in culture. J Trauma. 2002 Dec;53(6):1068-72. PMID:12478030

Gannon CJ, Napolitano LM. Severe anemia after gastrointestinal hemorrhage in a Jehovah's Witness: new treatment strategies. Crit Care Med. 2002 Aug;30(8):1893-5. PMID:12163811

Levy JH, Goodnough LT, Greilich PE, Parr GV, Stewart RW, Gratz I, et al. Polymerized bovine hemoglobin solution as a replacement for allogeneic red blood cell transfusion after cardiac surgery: results of a randomized, double-blind trial. J Thorac Cardiovasc Surg. 2002 Jul;124(1):35-42. PMID:12091806

Sprung J, Kindscher JD, Wahr JA, Levy JH, Monk TG, Moritz MW, et al. The use of bovine hemoglobin glutamer-250 (Hemopure) in surgical patients: results of a multicenter, randomized, single-blinded trial. Anesth Analg. 2002 Apr;94(4):799-808, table of contents. PMID:11916776

Hohenhaus AE. Oxyglobin: a transfusion solution? J Vet Intern Med. 2002 Jul-Aug;16(4):394-5. No abstract available. PMID:12141299

Lurie F, Jahr JS, Driessen B. Changes in circulating blood and plasma volume after hemoglobin-based oxygen carrier infusion and additional infusion of colloid solutions. Am J Ther. 2002 Sep-Oct;9(5):425-30. PMID:12237735

Arnoldo BD, Minei JP. Potential of hemoglobin-based oxygen carriers in trauma patients. Curr Opin Crit Care. 2001 Dec;7(6):431-6. Review. PMID:11805546

Hamilton RG, Kelly N, Gawryl MS, Rentko VT.
Absence of immunopathology associated with repeated IV administration of bovine Hb-based oxygen carrier in dogs.
Transfusion. 2001 Feb;41(2):219-25. PMID:11239226

Lok C. Blood product from cattle wins approval for use in humans. Nature. 2001 Apr 19;410(6831):855. No abstract available. PMID:11309575

Moon PF, Bliss SP, Posner LP, Erb HN, Nathanielsz PW. Fetal oxygen content is restored with Oxyglobin resuscitation after maternal hemorrhage. Vet Anaesth Analg. 2001 Apr;28(2):104-105. doi: 10.1046/j.1467-2987.2001.temp.doc.x-i10. Epub 2016 Nov 15. No abstract available. PMID:28404333

McNeil CJ, Smith LD, Jenkins LD, York MG, Josephs MJ. Hypotensive resuscitation using a polymerized bovine hemoglobin-based oxygen-carrying solution (HBOC-201) leads to reversal of anaerobic metabolism. J Trauma. 2001 Jun;50(6):1063-75. PMID:11426122

Posner LP, Moon PF, Bliss SP, Gleed RD, Erb HN.
Plasma colloid osmotic pressure after blood volume repletion with Oxyglobin, hetastarch, or whole blood in pregnant sheep. Vet Anaesth Analg. 2001 Apr;28(2):104. doi: 10.1046/j.1467-2987.2001.temp.doc.x-i9. Epub 2016 Nov 15. No abstract available. PMID:28404331

Manning JE, Katz LM, Pearce LB, Batson DN, McCurdy SL, Gawryl MS, et al. Selective aortic arch perfusion with hemoglobin-based oxygen carrier-201 for resuscitation from exsanguinating cardiac arrest in swine.Crit Care Med. 2001 Nov;29(11):2067-74. PMID:11700396

Driessen B, Jahr JS, Lurie F, Griffey SM, Gunther RA.
Effects of haemoglobin-based oxygen carrier hemoglobin glutamer-200 (bovine) on intestinal perfusion and oxygenation in a canine hypovolaemia model. Br J Anaesth. 2001 May;86(5):683-92. Erratum in: Br J Anaesth 2001 Aug;87(2):329. Br J Anaesth 2001 Jul;87(1):164. PMID:11575346

Driessen B, Jahr JS, Lurie F, Griffey SM, Gunther RA.
Effects of the haemoglobin-based oxygen carrier Hemoglobin glutamer-200 (bovine) on intestinal perfusion and oxygenation in a canine hypovolaemia model. Vet Anaesth Analg. 2001 Oct;28(4):204-205. doi: 10.1111/j.1467-2987.2001.064-2.x. Epub 2016 Nov 15. No abstract available. PMID:28404246

Horn EP, Burmeister MA. Bovine hemoglobin (HBOC-201) restores tissue oxygen tension during peripheral and coronary artery stenosis under extended hemodilution. Anasthesiol Intensivmed Notfallmed Schmerzther. 2001 Nov;36 Suppl 2:S117-8. No abstract available. PMID:11753715

Sprung J, Popp H, O'Hara P, Woletz J. The successful use of hemoglobin-based oxygen carrier as a primary blood substitute during abdominal aneurysm repair with large blood loss. Anesth Analg. 2001 Jun;92(6):1413-5. No abstract available. PMID:11375814

McEwen MM, Moon-Massat PF, Butler EC, Kollias GV.
Polymerized bovine hemoglobin (Oxyglobin Solution) administration in two river otters (Lutra canadensis). Vet Anaesth Analg. 2001 Oct;28(4):214-219. doi: 10.1046/j.1467-2987.2001.00055.x. Epub 2016 Nov 15. PMID:28404257

Grundy SA, Barton C. Influence of drug treatment on survival of dogs with immune-mediated hemolytic anemia: 88 cases (1989-1999). J Am Vet Med Assoc. 2001 Feb 15;218(4):543-6. PubMed PMID: 11229506

Standl T. Haemoglobin-based erythrocyte transfusion substitutes. Expert Opin Biol Ther. 2001 Sep;1(5):831-43. Review. PMID:11728218

Manning JE, Katz LM, Pearce LB, Batson DN, McCurdy SL, Gawryl MS, et al. Selective aortic arch perfusion with hemoglobin-based oxygen carrier-201 for resuscitation from exsanguinating cardiac arrest in swine.Crit Care Med. 2001 Nov;29(11):2067-74. PMID:11700396

Hill SE. Oxygen therapeutics--current concepts. Can J Anaesth. 2001 Apr;48(4 Suppl):S32-40. PMID:11336435.

Cheung AT, Jahr JS, Driessen B, Duong PL, Chan MS, Lurie F, Golkaryeh MS, Kullar RK, Gunther RA.
The effects of hemoglobin glutamer-200 (bovine) on the microcirculation in a canine hypovolemia model: a noninvasive computer-assisted intravital microscopy study. Anesth Analg. 2001 Oct;93(4):832-8. PMID:11574342

Driessen B, Jahr JS, Lurie F, Gunther RA.
Low-volume resuscitation with a haemoglobin-based oxygen carrier Hemoglobin glutamer-200 (bovine) in canine hypovolaemia. Vet Anaesth Analg. 2001 Oct;28(4):204. doi: 10.1111/j.1467-2987.2001.00064.x. Epub 2016 Nov 15. No abstract available. PMID:28404245

Manning JE, Katz LM, Brownstein MR, Pearce LB, Gawryl MS, Baker CC. Bovine hemoglobin-based oxygen carrier (HBOC-201) for resuscitation of uncontrolled, exsanguinating liver injury in swine. Carolina Resuscitation Research Group. Shock. 2000 Feb;13(2):152-9. PMID:10670846

Mullon J, Giacoppe G, Clagett C, McCune D, Dillard T. Transfusions of polymerized bovine hemoglobin in a patient with severe autoimmune hemolytic anemia. N Engl J Med. 2000 Jun 1;342(22):1638-43. No abstract available. PMID:10836875

Hohenhaus A, Rentko V. Blood Transfusions and Blood Substitutes. In: Stephen P. DiBartola. Fluid Therapy in Small Animal Practice. 2000 2nd edition. 451-464. WB Saunders Co;.2000

Muir WW 3rd, de Morais HS, Constable PD. The effects of a hemoglobin-based oxygen carrier (HBOC-301) on left ventricular systolic function in anesthetized dogs. Vet Surg. 2000 Sep-Oct;29(5):449-55. PMID:10999460

LaMuraglia GM, O'Hara PJ, Baker WH, Naslund TC, Norris EJ, Li J, et al. The reduction of the allogenic transfusion requirement in aortic surgery with a hemoglobin-based solution. J Vasc Surg. 2000 Feb;31(2):299-308. PMID:10664499

Mullon J, Giacoppe G, Clagett C, McCune D, Dillard T. Transfusions of polymerized bovine hemoglobin in a patient with severe autoimmune hemolytic anemia. N Engl J Med. 2000 Jun 1;342(22):1638-43. No abstract available. PMID:10836875

Jahr JS, Lurie F, Driessen B, Tang Z, Louie RF, Kost G. Validation of oxygen saturation measurements in a canine model of hemoglobin-based oxygen carrier infusion. Am J Ther. 2003 Jan-Feb;10(1):21-8. PMID:12522516

Hayward R, Lefer AM. Administration of polymerized bovine hemoglobin improves survival in a rat model of traumatic shock. Methods Find Exp Clin Pharmacol. 1999 Jul-Aug;21(6):427-33. PMID:10445236

Braden TD, Tvedten HW, DeCamp CE, Turner TM, Hughes GS, Rentko VT.
Radiographic, biomechanical, and pathologic effects of hemoglobin glutamer-200 in dogs undergoing cemented total hip arthroplasty. Am J Vet Res. 1999 Nov;60(11):1337-40. PMID:10566804

Standl T, Burmeister MA, Horn EP, Wilhelm S, Knoefel WT, Schulte am Esch J. Bovine haemoglobin-based oxygen carrier for patients undergoing haemodilution before liver resection. Br J Anaesth. 1998 Feb;80(2):189-94. PMID:9602583

Horn EP, Standl T, Wilhelm S, et al. Bovine hemoglobin. HBOC-201 causes a reduction of the oxygen partial pressure in poststenotic skeletal muscle]. Anaesthesist. 1998 Feb;47(2):116-23. German. PMID:9530461

Kasper SM, Grüne F, Walter M, Amr N, Erasmi H, Buzello W. The effects of increased doses of bovine hemoglobin on hemodynamics and oxygen transport in patients undergoing preoperative hemodilution for elective abdominal aortic surgery. Anesth Analg. 1998 Aug;87(2):284-91. PubMed PMID: 9706917.

Brauer P, Standl T, Wilhelm S, Burmeister MA, Schulte am Esch J. Transcranial Doppler sonography mean flow velocity during infusion of ultrapurified bovine hemoglobin. J Neurosurg Anesthesiol. 1998 Jul;10(3):146-52. PMID:9681402

Standl T, Wilhelm S, Horn EP, Burmeister M, Gundlach M, Schulte am Esch J. [Preoperative hemodilution with bovine hemoglobin. Acute hemodynamic effects in liver surgery patients ]. Anaesthesist. 1997 Sep;46(9):763-70. German. PMID:9412256

Gonzalez P, Hackney AC, Jones S, Strayhorn D, Hoffman EB, Hughes G, et al. A phase I/II study of polymerized bovine hemoglobin in adult patients with sickle cell disease not in crisis at the time of study. J Investig Med. 1997 Jun;45(5):258-64. PMID:9249998

Kasper SM, Walter M, Grüne F, Bischoff A, Erasmi H, Buzello W. Effects of a hemoglobin-based oxygen carrier (HBOC-201) on hemodynamics and oxygen transport in patients undergoing preoperative hemodilution for elective abdominal aortic surgery. Anesth Analg. 1996 Nov;83(5):921-7. PubMed PMID: 8895264

Rentko V et al. A Clinical Trial of a Hemoglobin Based Oxygen Carrying (HBOC) Fluid in the Treatment of Anemia in Dogs. J of Vet Int Med. ACVIM ABSTRACTS. 1996;10:177. doi:10.1111/j.1939-1676.1996.tb02047.x

Hughes GS, Francom SF, Antal EJ, et al. Effects of a novel hemoglobin-based oxygen carrier on percent oxygen saturation as determined with arterial blood gas analysis and pulse oximetry. Ann Emerg Med. 1996 Feb;27(2):164-9. PMID:8629746