Surgery

Transplantation of High-risk Donor Livers After Ex Situ Resuscitation and Assessment Using Combined Hypo- and Normothermic Machine Perfusion: A Prospective Clinical Trial

2019
Surgery
Citation

van Leeuwen OB, de Vries Y, Fujiyoshi M, Nijsten MWN, Ubbink R, Pelgrim GJ, et. al. Transplantation of High-risk Donor Livers After Ex Situ Resuscitation and Assessment Using Combined Hypo- and Normothermic Machine Perfusion: A Prospective Clinical Trial. Ann Surg. 2019 Nov;270(5):906-914. doi: 10.1097/SLA.0000000000003540. PubMed PMID: 31633615.

Link

Users Guide to Pitfalls and Lessons Learned About HBOC-201 During Clinical Trials, Expanded Access, and Clinical Use in 1,701 Patients

2019
Surgery
Citation

Mackenzie CF, Dubé GP, Pitman A, Zafirelis M. Users Guide to Pitfalls and Lessons Learned About HBOC-201 During Clinical Trials, Expanded Access, and Clinical Use in 1,701 Patients. Shock. 2019 Oct;52(1S Suppl 1):92-99. doi: 10.1097/SHK.0000000000001038. PMID:29076972

Link

Freeze-dried plasma mitigates the dilution effects of a hemoglobin-based oxygen carrier (HBOC-201) in a model of resuscitation for hemorrhage and hemodilution

2019
Surgery
Citation

Meledeo MA, Peltier GC, McIntosh CS, Taylor AS, Bynum JA, Pusateri AE, Cap AP. Freeze-dried plasma mitigates the dilution effects of a hemoglobin-based oxygen carrier (HBOC-201) in a model of resuscitation for hemorrhage and hemodilution. J Trauma Acute Care Surg. 2019 Jul;87(1S Suppl 1):S83-S90. doi: 10.1097/TA.0000000000002317. PMID:31246911

Link

Transplantation of high-risk donor livers after resuscitation and viability assessment using a combined protocol of oxygenated hypothermic, rewarming and normothermic machine perfusion: study protocol for a prospective, single-arm study (DHOPE-COR-NMP trial)

2019
Surgery
Citation

de Vries Y, Berendsen TA, Fujiyoshi M, van den Berg AP, Blokzijl H, de Boer MT, van der Heide F, de Kleine RHJ, van Leeuwen OB, Matton APM, Werner MJM, Lisman T, de Meijer VE, Porte R. Transplantation of high-risk donor livers after resuscitation and viability assessment using a combined protocol of oxygenated hypothermic, rewarming and normothermic machine perfusion: study protocol for a prospective, single-arm study (DHOPE-COR-NMP trial). BMJ Open. 2019 Aug 15;9(8):e028596. doi: 10.1136/bmjopen-2018-028596. PubMed PMID: 31420387; PubMed Central PMCID: PMC6701560.

Link

Hemoglobin-Based Oxygen Carrier Rescues Double-Transplant Patient From Life-Threatening Anemia

2017
Surgery
Citation

Gomez MF, Aljure O, Ciancio G, Lynn M. Hemoglobin-Based Oxygen Carrier Rescues Double-Transplant Patient From Life-Threatening Anemia. Am J Transplant. 2017 Jul;17(7):1941-1944. doi: 10.1111/ajt.14226. Epub 2017 Mar 17. PMID:28188676

Link

A safety and efficacy evaluation of hemoglobin-based oxygen carrier HBOC-201 in a randomized, multicenter red blood cell controlled trial in noncardiac surgery patients

2014
Surgery
Citation

Van Hemelrijck J, Levien LJ, Veeckman L, Pitman A, Zafirelis Z, Standl T. A safety and efficacy evaluation of hemoglobin-based oxygen carrier HBOC-201 in a randomized, multicenter red blood cell controlled trial in noncardiac surgery patients. Anesth Analg. 2014 Oct;119(4):766-76. doi: 10.1213/ANE.0000000000000305. PMID:24977631

Link

New and future resuscitation fluids for trauma patients using hemoglobin and hypertonic saline

2012
Surgery
Citation

Galvagno SM Jr, Mackenzie CF. New and future resuscitation fluids for trauma patients using hemoglobin and hypertonic saline. Anesthesiol Clin. 2013 Mar;31(1):1-19. doi: 10.1016/j.anclin.2012.10.004. Epub 2012 Dec 6. Review. PMID:23351531

Link

Vital organ tissue oxygenation after serial normovolemic exchange transfusion with HBOC-201 in anesthetized swine

2011
Surgery
Citation

Muir WW, Ilangovan G, Zweier JL, Moon-Massat PF, Rentko VT. Vital organ tissue oxygenation after serial normovolemic exchange transfusion with HBOC-201 in anesthetized swine. Shock 2011 Jun;35(6):597-603. doi: 10.1097/SHK.0b013e31821366f6. PMID:21330945 | PMCID:PMC3221463

Link

Does HBOC-201 (Hemopure) affect platelet function in orthopedic surgery: a single-site analysis from a multicenter study

2010
Surgery
Citation

Jahr JS, Liu H, Albert OK, Gull A, Moallempour M, Lim J, Gosselin R. Does HBOC-201 (Hemopure) affect platelet function in orthopedic surgery: a single-site analysis from a multicenter study. Am J Ther. 2010 Mar-Apr;17(2):140-7. doi: 10.1097/MJT.0b013e3181a2b08d. PMID:19417588

Link

HBOC-201 use in traumatic brain injury: case report and review of literature

2009
Surgery
Citation

Marinaro J, Smith J, Tawil I, Billstrand M, Crookston KP. HBOC-201 use in traumatic brain injury: case report and review of literature. Transfusion. 2009 Oct;49(10):2054-9. doi: 10.1111/j.1537-2995.2009.02235.x. Epub 2009 May 27. Review. PMID:19497051

Link

Regional blood flow after serial normovolemic exchange transfusion with HBOC-201 (Hemopure) in anesthetized swine

2009
Surgery
Citation

Mongan PD, Moon-Massat PF, Rentko V, Mihok S, Dragovich A, Sharma P. Regional blood flow after serial normovolemic exchange transfusion with HBOC-201 (Hemopure) in anesthetized swine. J Trauma. 2009 Jul;67(1):51-60. doi: 10.1097/TA.0b013e3181838030. PMID:19590308

Link

HBOC-201 vasoactivity in a phase III clinical trial in orthopedic surgery subjects--extrapolation of potential risk for acute trauma trials

2009
Surgery
Citation

Freilich D, Pearce LB, Pitman A, Greenburg G, Berzins M, Bebris L, et al. HBOC-201 vasoactivity in a phase III clinical trial in orthopedic surgery subjects--extrapolation of potential risk for acute trauma trials. J Trauma. 2009 Feb;66(2):365-76. doi: 10.1097/TA.0b013e3181820d5c. PMID:19204509

Link

The use of Hemopure® at Groote Schuur hospital, Cape Town: 4 case studies, Southern African Journal of Anaesthesia and Analgesia

2009
Surgery
Citation

HE Potgieter & MF James (2009) The use of Hemopure® at Groote Schuur hospital, Cape Town: 4 case studies, Southern African Journal of Anaesthesia and Analgesia, 15:1, 13-15, DOI: 10.1080/22201173.2009.10872581

Link

Haemoglobin, oxygen carriers and perioperative organ perfusion

2008
Surgery
Citation

Kocian R, Spahn DR. Haemoglobin, oxygen carriers and perioperative organ perfusion. Best Pract Res Clin Anaesthesiol. 2008 Mar;22(1):63-80. Review. PMID:18494389

Link

HBOC-201 as an alternative to blood transfusion: efficacy and safety evaluation in a multicenter phase III trial in elective orthopedic surgery

2008
Surgery
Citation

Jahr JS, Mackenzie C, Pearce LB, Pitman A, Greenburg AG. HBOC-201 as an alternative to blood transfusion: efficacy and safety evaluation in a multicenter phase III trial in elective orthopedic surgery. J Trauma. 2008 Jun;64(6):1484-97. doi:

Link

Resuscitation following severe, controlled hemorrhage associated with a 24 h delay to surgical intervention in swine using a hemoglobin based oxygen carrier as an oxygen bridge to definitive care

2007
Surgery
Citation

Philbin N, Handrigan M, Rice J, McNickle K, McGwin G, Williams R, et al. Resuscitation following severe, controlled hemorrhage associated with a 24 h delay to surgical intervention in swine using a hemoglobin based oxygen carrier as an oxygen bridge to definitive care. Resuscitation. 2007 Aug;74(2):332-43. Epub 2007 Mar 23. PMID:17383073

Link

A comparison of the acute hemodynamic and delayed effects of 50% exchange transfusion with two different cross-linked hemoglobin based oxygen carrying solutions and Pentastarch

2006
Surgery
Citation

Bonegio RG, Fuhro R, Ragno G, Robert Valeri C, Lieberthal W. A comparison of the acute hemodynamic and delayed effects of 50% exchange transfusion with two different cross-linked hemoglobin based oxygen carrying solutions and Pentastarch. Artif Cells Blood Substit Immobil Biotechnol. 2006;34(2):145-57. PMID:16537171

Link

Bovine hemoglobin-based oxygen-carrying solution (HBOC-201) improves flap survival in a rat model of epigastric flap failure

2006
Surgery
Citation

Ortegon DP, Davis MR, Sampson JB, Dick EJ, Kashyap V, Kerby JD. Bovine hemoglobin-based oxygen-carrying solution (HBOC-201) improves flap survival in a rat model of epigastric flap failure. Microsurgery. 2006;26(3):203-6. PMID:16493668

Link

The effects of a polymerized bovine-derived hemoglobin solution in a rabbit model of arterial thrombosis and bleeding

2004
Surgery
Citation

Marret E, Bonnin P, Mazoyer E, Riou B, Jacobs T, Coriat P, Samama CM. The effects of a polymerized bovine-derived hemoglobin solution in a rabbit model of arterial thrombosis and bleeding. Anesth Analg. 2004 Mar;98(3):604-10, table of contents. PMID:14980905

Link

Hemoglobin substitutes

2004
Surgery
Citation

Anbari KK, Garino JP, Mackenzie CF. Hemoglobin substitutes. Eur Spine J. 2004 Oct;13 Suppl 1:S76-82. Epub 2004 May 27. Review. PMID:15168238 | PMCID:PMC3592184

Link

The use of haemoglobin glutamer-250 (HBOC-201) as an oxygen bridge in patients with acute anaemia associated with surgical blood loss

2003
Surgery
Citation

Levy JH. The use of haemoglobin glutamer-250 (HBOC-201) as an oxygen bridge in patients with acute anaemia associated with surgical blood loss. Expert Opin Biol Ther. 2003 Jun;3(3):509-17. Review. Erratum in: Expert Opin Biol Ther. 2003 Sep;3(6):1017. PMID:12783619

Link

The use of bovine hemoglobin glutamer-250 (Hemopure) in surgical patients: results of a multicenter, randomized, single-blinded trial

2002
Surgery
Citation

Sprung J, Kindscher JD, Wahr JA, Levy JH, Monk TG, Moritz MW, et al. The use of bovine hemoglobin glutamer-250 (Hemopure) in surgical patients: results of a multicenter, randomized, single-blinded trial. Anesth Analg. 2002 Apr;94(4):799-808, table of contents. PMID:11916776

Link

Severe anemia after gastrointestinal hemorrhage in a Jehovah's Witness: new treatment strategies

2002
Surgery
Citation

Gannon CJ, Napolitano LM. Severe anemia after gastrointestinal hemorrhage in a Jehovah's Witness: new treatment strategies. Crit Care Med. 2002 Aug;30(8):1893-5. PMID:12163811

Link

Polymerized bovine hemoglobin solution as a replacement for allogeneic red blood cell transfusion after cardiac surgery: results of a randomized, double-blind trial

2002
Surgery
Citation

Levy JH, Goodnough LT, Greilich PE, Parr GV, Stewart RW, Gratz I, et al. Polymerized bovine hemoglobin solution as a replacement for allogeneic red blood cell transfusion after cardiac surgery: results of a randomized, double-blind trial. J Thorac Cardiovasc Surg. 2002 Jul;124(1):35-42. PMID:12091806

Link

Extracorporeal membrane oxygenation in piglets using a polymerized bovine hemoglobin-based oxygen-carrying solution (HBOC-201)

2002
Surgery
Citation

York GB, DiGeronimo RJ, Wilson BJ, Cofer BR, Breuer CK, Josephs JD, et al. Extracorporeal membrane oxygenation in piglets using a polymerized bovine hemoglobin-based oxygen-carrying solution (HBOC-201). J Pediatr Surg. 2002 Oct;37(10):1387-92. PMID:12378440

Link

The Successful Use of Hemoglobin-Based Oxygen Carrier as a Primary Blood Substitute During Abdominal Aneurysm Repair with Large Blood Loss

2001
Surgery
Citation

Sprung J, Popp H, O'Hara P, Woletz J. The successful use of hemoglobin-based oxygen carrier as a primary blood substitute during abdominal aneurysm repair with large blood loss. Anesth Analg. 2001 Jun;92(6):1413-5. No abstract available. PMID:11375814

Link

The reduction of the allogenic transfusion requirement in aortic surgery with a hemoglobin-based solution

2000
Surgery
Citation

LaMuraglia GM, O'Hara PJ, Baker WH, Naslund TC, Norris EJ, Li J, et al. The reduction of the allogenic transfusion requirement in aortic surgery with a hemoglobin-based solution. J Vasc Surg. 2000 Feb;31(2):299-308. PMID:10664499

Link

The effects of increased doses of bovine hemoglobin on hemodynamics and oxygen transport in patients undergoing preoperative hemodilution for elective abdominal aortic surgery

1998
Surgery
Citation

Kasper SM, Grüne F, Walter M, Amr N, Erasmi H, Buzello W. The effects of increased doses of bovine hemoglobin on hemodynamics and oxygen transport in patients undergoing preoperative hemodilution for elective abdominal aortic surgery. Anesth Analg. 1998 Aug;87(2):284-91. PubMed PMID: 9706917.

Link

Bovine haemoglobin-based oxygen carrier for patients undergoing haemodilution before liver resection

1998
Surgery
Citation

Standl T, Burmeister MA, Horn EP, Wilhelm S, Knoefel WT, Schulte am Esch J. Bovine haemoglobin-based oxygen carrier for patients undergoing haemodilution before liver resection. Br J Anaesth. 1998 Feb;80(2):189-94. PMID:9602583

Link

Preoperative hemodilution with bovine hemoglobin. Acute hemodynamic effects in liver surgery patients

1997
Surgery
Citation

Standl T, Wilhelm S, Horn EP, Burmeister M, Gundlach M, Schulte am Esch J. [Preoperative hemodilution with bovine hemoglobin. Acute hemodynamic effects in liver surgery patients ]. Anaesthesist. 1997 Sep;46(9):763-70. German. PMID:9412256

Link

Effects of a hemoglobin-based oxygen carrier (HBOC-201) on hemodynamics and oxygen transport in patients undergoing preoperative hemodilution for elective abdominal aortic surgery

1996
Surgery
Citation

Kasper SM, Walter M, Grüne F, Bischoff A, Erasmi H, Buzello W. Effects of a hemoglobin-based oxygen carrier (HBOC-201) on hemodynamics and oxygen transport in patients undergoing preoperative hemodilution for elective abdominal aortic surgery. Anesth Analg. 1996 Nov;83(5):921-7. PubMed PMID: 8895264

Link

Effects of a hemoglobin-based oxygen carrier (HBOC-201) on hemodynamics and oxygen transport in patients undergoing preoperative hemodilution for elective abdominal aortic surgery

1996
Surgery
Citation

Kasper SM, Walter M, Grüne F, Bischoff A, Erasmi H, Buzello W. Effects of a hemoglobin-based oxygen carrier (HBOC-201) on hemodynamics and oxygen transport in patients undergoing preoperative hemodilution for elective abdominal aortic surgery. Anesth Analg. 1996 Nov;83(5):921-7. PubMed PMID: 8895264

Link

© 2020  Hemoglobin Oxygen Therapeutics LLC