Oxyglobin

The effects of hemoglobin glutamer-200 and iNO on pulmonary vascular tone and arterial oxygenation in an experimental acute respiratory distress syndrome

2018
Oxyglobin
Citation

Voelker MT, Bergmann A, Busch T, Jahn N, Laudi S, Noreikat K, et. al. The effects of hemoglobin glutamer-200 and iNO on pulmonary vascular tone and arterial oxygenation in an experimental acute respiratory distress syndrome. Pulm. Pharmacol Ther. 2018 Apr;49:130-133. doi: 10.1016/j.pupt.2018.01.009. Epub 2018. Feb 6. PubMed PMID: 29425776.

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Feline non-regenerative immune-mediated anaemia: features and outcome in 15 cases

2016
Oxyglobin
Citation

Black V, Adamantos S, Barfield D, Tasker S. Feline non-regenerative immune-mediated anaemia: features and outcome in 15 cases. J Feline Med Surg. 2016 Aug;18(8):597-602. doi: 10.1177/1098612X15588800. Epub 2015 Jun 26. PMID:26116621

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A successful transfusion in a tamandua (Tamandua tetradactyla) using both whole blood and blood replacement products

2015
Oxyglobin
Citation

Raines JA, Storms T. A successful transfusion in a tamandua (Tamandua tetradactyla) using both whole blood and blood replacement products. J Zoo Wildl Med. 2015 Mar;46(1):161-3. PMID:25831593

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HbG200-mediated preinduction of heme oxygenase-1 improves bile flow and ameliorates pericentral downregulation of Bsep and Mrp2 following experimental liver ischemia and reperfusion

2013
Oxyglobin
Citation

Donner MG, Topp SA, Cebula P, Krienen A, Gehrmann T, Sommerfeld A, et al.HbG200-mediated preinduction of heme oxygenase-1 improves bile flow and ameliorates pericentral downregulation of Bsep and Mrp2 following experimental liver ischemia and reperfusion. Biol Chem. 2013 Jan;394(1):97-112. doi: 10.1515/hsz-2012-0153. PMID:23096566

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A bovine hemoglobin-based oxygen carrier as pump prime for cardiopulmonary bypass: reduced systemic lactic acidosis and improved cerebral oxygen metabolism during low flow in a porcine model

2011
Oxyglobin
Citation

McNeil JD, Propper B, Walker J, Holguin L, Evans L, Lee K, Fox PT, Michalek JE, Baisden CE. A bovine hemoglobin-based oxygen carrier as pump prime for cardiopulmonary bypass: reduced systemic lactic acidosis and improved cerebral oxygen metabolism during low flow in a porcine model. J Thorac Cardiovasc Surg. 2011 Aug;142(2):411-7. doi: 10.1016/j.jtcvs.2010.11.017. PMID:21641005

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Evaluation of the effects of bovine hemoglobin glutamer-200 on systolic arterial blood pressure in hypotensive cats: 44 cases (1997-2008)

2011
Oxyglobin
Citation

Wehausen CE, Kirby R, Rudloff E. Evaluation of the effects of bovine hemoglobin glutamer-200 on systolic arterial blood pressure in hypotensive cats: 44 cases (1997-2008). J Am Vet Med Assoc. 2011 Apr 1;238(7):909-14. doi: 10.2460/javma.238.7.909. PMID:21453180

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Comparison of fluid types for resuscitation after acute blood loss in mallard ducks (Anas platyrhynchos)

2009
Oxyglobin
Citation

Singleton CL, Oosterhuis JE, Seibold K, Lamberski N. Successful treatment of a southern Pacific rattlesnake (Crotalus viridis helleri) bite in a caracal (Caracal caracal). J Zoo Wildl Med. 2009 Jun;40(2):378-81. PMID:19569491

Lichtenberger M, Orcutt C, Cray C, Thamm DH, DeBehnke D, Page C, et al. Comparison of fluid types for resuscitation after acute blood loss in mallard ducks (Anas platyrhynchos). J Vet Emerg Crit Care (San Antonio). 2009 Oct;19(5):467-72. doi: 10.1111/j.1476-4431.2009.00465.x. PMID:19821888

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A prospective, randomized comparison of Oxyglobin (HB-200) and packed red blood cell transfusion for canine babesiosis

2009
Oxyglobin
Citation

Zambelli AB, Leisewitz AL. A prospective, randomized comparison of Oxyglobin (HB-200) and packed red blood cell transfusion for canine babesiosis. J Vet Emerg Crit Care (San Antonio). 2009 Feb;19(1):102-12. doi: 10.1111/j.1476-4431.2009.00386.x. PMID:19691591

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Successful treatment of a southern Pacific rattlesnake (Crotalus viridis helleri) bite in a caracal (Caracal caracal)

2009
Oxyglobin
Citation

Singleton CL, Oosterhuis JE, Seibold K, Lamberski N. Successful treatment of a southern Pacific rattlesnake (Crotalus viridis helleri) bite in a caracal (Caracal caracal). J Zoo Wildl Med. 2009 Jun;40(2):378-81. PMID:19569491

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Methemoglobin effects on coagulation: a dose-response study with HBOC-200 (Oxyglobin) in a thrombelastogram model

2009
Oxyglobin
Citation

Moallempour M, Jahr JS, Lim JC, Weeks D, Butch A, Driessen B. Methemoglobin effects on coagulation: a dose-response study with HBOC-200 (Oxyglobin) in a thrombelastogram model. J Cardiothorac Vasc Anesth. 2009 Feb;23(1):41-7. doi: 10.1053/j.jvca.2008.06.006. Epub 2008 Aug 29. PMID:18834828

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Measuring circulating blood volume using infused hemoglobin-based oxygen carrier (oxyglobin) as an indicator: verification in a canine hypovolemia model

2008
Oxyglobin
Citation

Jahr JS, Lurie F, Bezdikian V, Driessen B, Gunther RA. Measuring circulating blood volume using infused hemoglobin-based oxygen carrier (oxyglobin) as an indicator: verification in a canine hypovolemia model. Am J Ther. 2008 Mar-Apr;15(2):98-101. doi: 10.1097/MJT.0b013e31804c6f98. PMID:18356627

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Clinical use of a haemoglobin-based oxygen carrying solution (Oxyglobin) in 48 cats (2002-2006)

2008
Oxyglobin
Citation

Weingart C, Kohn B. Clinical use of a haemoglobin-based oxygen carrying solution (Oxyglobin) in 48 cats (2002-2006).
J Feline Med Surg. 2008 Oct;10(5):431-8. doi: 10.1016/j.jfms.2007.10.012. Epub 2008 May 2. PMID:18455461

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Hemoglobin-glutamer 200 reduces reperfusion injury of the cold preserved rat liver by induction of heme oxygenase-1

2008
Oxyglobin
Citation

Topp SA, Krieg A, Koch A, Tidden CM, Ramp U, Hohlfeld T, et al. Hemoglobin-glutamer 200 reduces reperfusion injury of the cold preserved rat liver by induction of heme oxygenase-1. J Surg Res. 2008 Dec;150(2):243-54. doi: 10.1016/j.jss.2008.02.033. Epub 2008 Mar 18. PMID:18395753

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Effects of low-volume hemoglobin glutamer-200 versus normal saline and arginine vasopressin resuscitation on systemic and skeletal muscle blood flow and oxygenation in a canine hemorrhagic shock model

2007
Oxyglobin
Citation

Driessen B, Zarucco L, Gunther RA, Burns PM, Lamb SV, Vincent SE, et al. Effects of low-volume hemoglobin glutamer-200 versus normal saline and arginine vasopressin resuscitation on systemic and skeletal muscle blood flow and oxygenation in a canine hemorrhagic shock model. Crit Care Med. 2007 Sep;35(9):2101-9. PMID:17581486

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Effects of isovolemic resuscitation with hemoglobin-based oxygen carrier Hemoglobin glutamer-200 (bovine) on systemic and mesenteric perfusion and oxygenation in a canine model of hemorrhagic shock: a comparison with 6% hetastarch solution and shed blood

2006
Oxyglobin
Citation

Driessen B, Jahr JS, Lurie F, Gunther RA.
Effects of isovolemic resuscitation with hemoglobin-based oxygen carrier Hemoglobin glutamer-200 (bovine) on systemic and mesenteric perfusion and oxygenation in a canine model of hemorrhagic shock: a comparison with 6% hetastarch solution and shed blood. Vet Anaesth Analg. 2006 Nov;33(6):368-80. PMID:17083609

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Improvement of impaired microcirculation and tissue oxygenation by hemodilution with hydroxyethyl starch plus cell-free hemoglobin in acute porcine pancreatitis

2006
Oxyglobin
Citation

Freitag M, Standl TG, Kleinhans H, Gottschalk A, Mann O, Rempf C, Bachmann K, Gocht A, Petri S, Izbicki JR, Strate T. Improvement of impaired microcirculation and tissue oxygenation by hemodilution with hydroxyethyl starch plus cell-free hemoglobin in acute porcine pancreatitis. Pancreatology. 2006;6(3):232-9. Epub 2006 Mar 9. PMID:16534248

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N-terminal adducts of bovine hemoglobin with glutaraldehyde in a hemoglobin-based oxygen carrier

2005
Oxyglobin
Citation

Gasthuys M, Alves S, Tabet JC. N-terminal adducts of bovine hemoglobin with glutaraldehyde in a hemoglobin-based oxygen carrier. Anal Chem. 2005 May 15;77(10):3372-8. PMID:15889931

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Effects of prophylactic or therapeutic application of bovine haemoglobin HBOC-200 on ischaemia-reperfusion injury following acute coronary ligature in rats

2005
Oxyglobin
Citation

Burmeister MA, Rempf C, Standl TG, Rehberg S, Bartsch-Zwemke S, Krause T, et al.
Effects of prophylactic or therapeutic application of bovine haemoglobin HBOC-200 on ischaemia-reperfusion injury following acute coronary ligature in rats. Br J Anaesth. 2005 Dec;95(6):737-45. Epub 2005 Oct 14. PMID:16227339

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Microcirculatory function and tissue damage is improved after therapeutic injection of bovine hemoglobin in severe acute rodent pancreatitis

2005
Oxyglobin
Citation

Strate T, Mann O, Kleinhans H, Rusani S, Schneider C, Yekebas E, Freitag M, Standl T, Bloechle C, Izbicki JR. Microcirculatory function and tissue damage is improved after therapeutic injection of bovine hemoglobin in severe acute rodent pancreatitis. Pancreas. 2005 Apr;30(3):254-9. PMID:15782104

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The pharmacokinetics of hemoglobin-based oxygen carrier hemoglobin glutamer-200 bovine in the horse

2005
Oxyglobin
Citation

Soma LR, Uboh CE, Guan F, Luo Y, Moate PJ, Boston RC, Driessen B. The pharmacokinetics of hemoglobin-based oxygen carrier hemoglobin glutamer-200 bovine in the horse. Anesth Analg. 2005 Jun;100(6):1570-5. PMID:15920176

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Detection of hemoglobin-based oxygen carriers in human serum for doping analysis: screening by electrophoresis

2004
Oxyglobin
Citation

Lasne F, Crepin N, Ashenden M, Audran M, de Ceaurriz J.
Detection of hemoglobin-based oxygen carriers in human serum for doping analysis: screening by electrophoresis.
Clin Chem. 2004 Feb;50(2):410-5. Epub 2003 Nov 21. PMID:14633908

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Transfusion medicine in exotic pets

2004
Oxyglobin
Citation

Lichtenberger M. Transfusion medicine in exotic pets. Clin Tech Small Anim Pract. 2004 May;19(2):88-95. Review. PMID:15179929

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Detection of hemoglobin-based oxygen carriers in human serum for doping analysis: confirmation by size-exclusion HPLC

2004
Oxyglobin
Citation

Varlet-Marie E, Ashenden M, Lasne F, Sicart MT, Marion B, de Ceaurriz J, Audran M.
Detection of hemoglobin-based oxygen carriers in human serum for doping analysis: confirmation by size-exclusion HPLC.
Clin Chem. 2004 Apr;50(4):723-31. Epub 2004 Feb 5. PMID:14764640

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Confirmation and quantification of hemoglobin-based oxygen carriers in equine and human plasma by hyphenated liquid chromatography tandem mass spectrometry

2004
Oxyglobin
Citation

Guan F, Uboh CE, Soma LR, Luo Y, Jahr JS, Driessen B.
Confirmation and quantification of hemoglobin-based oxygen carriers in equine and human plasma by hyphenated liquid chromatography tandem mass spectrometry Anal Chem. 2004 Sep 1;76(17):5127-35. PMID:15373452

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Validation of oxygen saturation measurements in a canine model of hemoglobin-based oxygen carrier infusion

2003
Oxyglobin
Citation

Jahr JS, Lurie F, Driessen B, Tang Z, Louie RF, Kost G. Validation of oxygen saturation measurements in a canine model of hemoglobin-based oxygen carrier infusion. Am J Ther. 2003 Jan-Feb;10(1):21-8. PMID:12522516

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Colloid osmotic pressure after hemorrhage and replenishment with Oxyglobin Solution, hetastarch, or whole blood in pregnant sheep

2003
Oxyglobin
Citation

Posner LP, Moon PF, Bliss SP, Gleed RD, Erb HN.
Colloid osmotic pressure after hemorrhage and replenishment with Oxyglobin Solution, hetastarch, or whole blood in pregnant sheep. Vet Anaesth Analg. 2003 Jan;30(1):30-6. PMID:14498915

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Clinical application of a hemoglobin-based oxygen-carrying solution

2003
Oxyglobin
Citation

Callan MB, Rentko VT. Clinical application of a hemoglobin-based oxygen-carrying solution. Vet Clin North Am Small Anim Pract. 2003 Nov;33(6):1277-93, vi. Review. PMID:14664199

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Systemic intravenous infusion of bovine hemoglobin significantly reduces microcirculatory dysfunction in experimentally induced pancreatitis in the rat

2003
Oxyglobin
Citation

Strate T, Mann O, Kleinhans H, Schneider C, Knoefel WT, Yekebas E, et al. Systemic intravenous infusion of bovine hemoglobin significantly reduces microcirculatory dysfunction in experimentally induced pancreatitis in the rat. Ann Surg. 2003 Nov;238(5):765-71. PMID:14578741 | PMCID:PMC1356157

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Validity of arterial and mixed venous oxygen saturation measurements in a canine hemorrhage model after resuscitation with varying concentrations of hemoglobin-based oxygen carrier

2003
Oxyglobin
Citation

Lurie F, Driessen B, Jahr JS, Reynoso R, Gunther RA. Validity of arterial and mixed venous oxygen saturation measurements in a canine hemorrhage model after resuscitation with varying concentrations of hemoglobin-based oxygen carrier. Anesth Analg. 2003 Jan;96(1):46-50, table of contents. PMID:12505921

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Arterial oxygenation and oxygen delivery after hemoglobin-based oxygen carrier infusion in canine hypovolemic shock: a dose-response study

2003
Oxyglobin
Citation

Driessen B, Jahr JS, Lurie F, Golkaryeh MS, Gunther RA. Arterial oxygenation and oxygen delivery after hemoglobin-based oxygen carrier infusion in canine hypovolemic shock: a dose-response study. Crit Care Med. 2003 Jun;31(6):1771-9. PMID:12794419

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Oxyglobin: a transfusion solution?

2002
Oxyglobin
Citation

Hohenhaus AE. Oxyglobin: a transfusion solution? J Vet Intern Med. 2002 Jul-Aug;16(4):394-5. No abstract available. PMID:12141299

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Changes in circulating blood and plasma volume after hemoglobin-based oxygen carrier infusion and additional infusion of colloid solutions

2002
Oxyglobin
Citation

Lurie F, Jahr JS, Driessen B. Changes in circulating blood and plasma volume after hemoglobin-based oxygen carrier infusion and additional infusion of colloid solutions. Am J Ther. 2002 Sep-Oct;9(5):425-30. PMID:12237735

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Role of redox potential of hemoglobin-based oxygen carriers on methemoglobin reduction by plasma components

2002
Oxyglobin
Citation

Dorman SC, Kenny CF, Miller L, Hirsch RE, Harrington JP. Role of redox potential of hemoglobin-based oxygen carriers on methemoglobin reduction by plasma components. Artif Cells Blood Substit Immobil Biotechnol. 2002 Jan;30(1):39-51. PMID:12000225

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Low-volume resuscitation with a haemoglobin-based oxygen carrier Hemoglobin glutamer-200 (bovine) in canine hypovolaemia

2001
Oxyglobin
Citation

Driessen B, Jahr JS, Lurie F, Gunther RA.
Low-volume resuscitation with a haemoglobin-based oxygen carrier Hemoglobin glutamer-200 (bovine) in canine hypovolaemia. Vet Anaesth Analg. 2001 Oct;28(4):204. doi: 10.1111/j.1467-2987.2001.00064.x. Epub 2016 Nov 15. No abstract available. PMID:28404245

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The effects of hemoglobin glutamer-200 (bovine) on the microcirculation in a canine hypovolemia model: a noninvasive computer-assisted intravital microscopy study

2001
Oxyglobin
Citation

Cheung AT, Jahr JS, Driessen B, Duong PL, Chan MS, Lurie F, Golkaryeh MS, Kullar RK, Gunther RA.
The effects of hemoglobin glutamer-200 (bovine) on the microcirculation in a canine hypovolemia model: a noninvasive computer-assisted intravital microscopy study. Anesth Analg. 2001 Oct;93(4):832-8. PMID:11574342

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Polymerized bovine hemoglobin (Oxyglobin Solution) administration in two river otters (Lutra canadensis)

2001
Oxyglobin
Citation

McEwen MM, Moon-Massat PF, Butler EC, Kollias GV.
Polymerized bovine hemoglobin (Oxyglobin Solution) administration in two river otters (Lutra canadensis).
Vet Anaesth Analg. 2001 Oct;28(4):214-219. doi: 10.1046/j.1467-2987.2001.00055.x. Epub 2016 Nov 15. PMID:28404257

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Effects of the haemoglobin-based oxygen carrier Hemoglobin glutamer-200 (bovine) on intestinal perfusion and oxygenation in a canine hypovolaemia model

2001
Oxyglobin
Citation

Driessen B, Jahr JS, Lurie F, Griffey SM, Gunther RA.
Effects of the haemoglobin-based oxygen carrier Hemoglobin glutamer-200 (bovine) on intestinal perfusion and oxygenation in a canine hypovolaemia model. Vet Anaesth Analg. 2001 Oct;28(4):204-205. doi: 10.1111/j.1467-2987.2001.064-2.x. Epub 2016 Nov 15. No abstract available. PMID:28404246

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Effects of haemoglobin-based oxygen carrier hemoglobin glutamer-200 (bovine) on intestinal perfusion and oxygenation in a canine hypovolaemia model

2001
Oxyglobin
Citation

Driessen B, Jahr JS, Lurie F, Griffey SM, Gunther RA.
Effects of haemoglobin-based oxygen carrier hemoglobin glutamer-200 (bovine) on intestinal perfusion and oxygenation in a canine hypovolaemia model. Br J Anaesth. 2001 May;86(5):683-92. Erratum in: Br J Anaesth 2001 Aug;87(2):329. Br J Anaesth 2001 Jul;87(1):164. PMID:11575346

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Plasma colloid osmotic pressure after blood volume repletion with Oxyglobin, hetastarch, or whole blood in pregnant sheep

2001
Oxyglobin
Citation

Posner LP, Moon PF, Bliss SP, Gleed RD, Erb HN.
Plasma colloid osmotic pressure after blood volume repletion with Oxyglobin, hetastarch, or whole blood in pregnant sheep. Vet Anaesth Analg. 2001 Apr;28(2):104. doi: 10.1046/j.1467-2987.2001.temp.doc.x-i9. Epub 2016 Nov 15. No abstract available. PMID:28404331

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Fetal oxygen content is restored with Oxyglobin resuscitation after maternal hemorrhage

2001
Oxyglobin
Citation

Moon PF, Bliss SP, Posner LP, Erb HN, Nathanielsz PW. Fetal oxygen content is restored with Oxyglobin resuscitation after maternal hemorrhage. Vet Anaesth Analg. 2001 Apr;28(2):104-105. doi: 10.1046/j.1467-2987.2001.temp.doc.x-i10. Epub 2016 Nov 15. No abstract available. PMID:28404333

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Absence of immunopathology associated with repeated IV administration of bovine Hb-based oxygen carrier in dogs

2001
Oxyglobin
Citation

Hamilton RG, Kelly N, Gawryl MS, Rentko VT.
Absence of immunopathology associated with repeated IV administration of bovine Hb-based oxygen carrier in dogs.
Transfusion. 2001 Feb;41(2):219-25. PMID:11239226

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Influence of drug treatment on survival of dogs with immune-mediated hemolytic anemia: 88 cases (1989-1999)

2001
Oxyglobin
Citation

Grundy SA, Barton C. Influence of drug treatment on survival of dogs with immune-mediated hemolytic anemia: 88 cases (1989-1999). J Am Vet Med Assoc. 2001 Feb 15;218(4):543-6. PubMed PMID: 11229506

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Absence of immunopathology associated with repeated IV administration of bovine Hb-based oxygen carrier in dogs

2001
Oxyglobin
Citation

Hamilton RG, Kelly N, Gawryl MS, Rentko VT. Absence of immunopathology associated with repeated IV administration of bovine Hb-based oxygen carrier in dogs. Transfusion. 2001 Feb;41(2):219-25. PMID:11239226

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The effects of a hemoglobin-based oxygen carrier (HBOC-301) on left ventricular systolic function in anesthetized dogs

2000
Oxyglobin
Citation

Muir WW 3rd, de Morais HS, Constable PD. The effects of a hemoglobin-based oxygen carrier (HBOC-301) on left ventricular systolic function in anesthetized dogs. Vet Surg. 2000 Sep-Oct;29(5):449-55. PMID:10999460

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Fluid Therapy in Small Animal Practice

2000
Oxyglobin
Citation

Hohenhaus A, Rentko V. Blood Transfusions and Blood Substitutes. In: Stephen P. DiBartola. Fluid Therapy in Small Animal Practice. 2000 2nd edition. 451-464. WB Saunders Co;.2000

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Validation of oxygen saturation measurements in a canine model of hemoglobin based oxygen carrier (HBOC) infusion

2000
Oxyglobin
Citation

Jahr JS, Lurie F, Driessen B, Tang Z, Louie RF, Kost G. Validation of oxygen saturation measurements in a canine model of hemoglobin-based oxygen carrier infusion. Am J Ther. 2003 Jan-Feb;10(1):21-8. PMID:12522516

Link

Radiographic, biomechanical, and pathologic effects of hemoglobin glutamer-200 in dogs undergoing cemented total hip arthroplasty

1999
Oxyglobin
Citation

Braden TD, Tvedten HW, DeCamp CE, Turner TM, Hughes GS, Rentko VT.
Radiographic, biomechanical, and pathologic effects of hemoglobin glutamer-200 in dogs undergoing cemented total hip arthroplasty. Am J Vet Res. 1999 Nov;60(11):1337-40. PMID:10566804

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A Clinical Trial of a Hemoglobin Based Oxygen Carrying (HBOC) Fluid in the Treatment of Anemia in Dogs

1996
Oxyglobin
Citation

Rentko V et al. A Clinical Trial of a Hemoglobin Based Oxygen Carrying (HBOC) Fluid in the Treatment of Anemia in Dogs. J of Vet Int Med. ACVIM ABSTRACTS. 1996;10:177. doi:10.1111/j.1939-1676.1996.tb02047.x

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Red blood cell substitutes

1992
Oxyglobin
Citation

Rentko VT. Red blood cell substitutes. Probl Vet Med. 1992 Dec;4(4):647-51. Review. PubMed PMID: 1472775

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