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Relative Efficacies of HBOC-201 and Polyheme to Increase Oxygen Transport Compared to Blood and Crystalloids

2019
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Dubé GP, Pitman AN, Mackenzie CF. Relative Efficacies of HBOC-201 and Polyheme to Increase Oxygen Transport Compared to Blood and Crystalloids. Shock. 2019 Oct;52(1S Suppl 1):100-107. doi: 10.1097/SHK.0000000000001058. PMID:29140831

Normalization of hemoglobin-based oxygen carrier-201 induced vasoconstriction: targeting nitric oxide and endothelin

2017
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Taverne YJ, de Wijs-Meijler D, Te Lintel Hekkert M, Moon-Massat PF, Dubé GP, Duncker DJ, Merkus D. Normalization of hemoglobin-based oxygen carrier-201 induced vasoconstriction: targeting nitric oxide and endothelin. J Appl Physiol (1985). 2017 May 1;122(5):1227-1237. doi: 10.1152/japplphysiol.00677.2016. Epub 2017 Feb 9. PubMed PMID: 28183818.

Absence of developmental toxicity in a canine model after infusion of a hemoglobin-based oxygen carrier: Implications for risk assessment

2015
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Holson JF, Stump DG, Pearce LB, Watson RE, DeSesso JM. Absence of developmental toxicity in a canine model after infusion of a hemoglobin-based oxygen carrier: Implications for risk assessment. Reprod Toxicol. 2015 Apr;52:101-7. doi: 10.1016/j.reprotox.2015.01.006. Epub 2015 Feb 16. PMID:25697570

Resuscitation from hemorrhagic shock using polymerized hemoglobin compared to blood

2014
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Ortiz D, Barros M, Yan S, Cabrales P. Resuscitation from hemorrhagic shock using polymerized hemoglobin compared to blood. Am J Emerg Med. 2014 Mar;32(3):248-55. doi: 10.1016/j.ajem.2013.11.045. Epub 2013 Dec 7. PMID:24418449 | PMCID:PMC4049234

Crosslinked, polymerized, and PEG-conjugated hemoglobin-based oxygen carriers: clinical safety and efficacy of recent and current products

2012
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Jahr JS, Akha AS, Holtby RJ. Crosslinked, polymerized, and PEG-conjugated hemoglobin-based oxygen carriers: clinical safety and efficacy of recent and current products. Curr Drug Discov Technol. 2012 Sep;9(3):158-65. Review. PMID:21745179

Reconstructing hemoglobin-based oxygen carriers

2010
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Greenburg AG, Light WR, Dubé GP. Reconstructing hemoglobin-based oxygen carriers. Transfusion. 2010 Dec;50(12):2764-7; author reply 2767. doi: 10.1111/j.1537-2995.2010.02814.x. No abstract available. PMID:21126254

Haemoglobin-based oxygen carriers: is the benefit worth the risk?

2009
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Mackenzie CF. Haemoglobin-based oxygen carriers: is the benefit worth the risk? Br J Hosp Med (Lond). 2009 Jan;70(1):26-30. PMID:19357574

Prevention of the pulmonary vasoconstrictor effects of HBOC-201 in awake lambs by continuously breathing nitric oxide. Anesthesiology.

2009
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Yu B, Volpato GP, Chang K, Bloch KD, Zapol WM. Prevention of the pulmonary vasoconstrictor effects of HBOC-201 in awake lambs by continuously breathing nitric oxide. Anesthesiology. 2009 Jan;110(1):113-22. doi: 10.1097/ALN.0b013e318190bc4f. PMID:19104178 | PMCID:PMC2704389

Sodium nitrite therapy attenuates the hypertensive effects of HBOC-201 via nitrite reduction

2009
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Rodriguez C, Vitturi DA, He J, Vandromme M, Brandon A, Hutchings A, Rue LW 3rd, Kerby JD, Patel RP. Sodium nitrite therapy attenuates the hypertensive effects of HBOC-201 via nitrite reduction. Biochem J. 2009 Aug 27;422(3):423-32. doi: 10.1042/BJ20090735. PMID:19555351 | PMCID:PMC2775055

Blood alternative products: correction regarding Jehovah's Witnesses.

2009
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Muller CF. Blood alternative products: correction regarding Jehovah's Witnesses. S Afr Med J. 2009 Feb;99(2):72, 74; author reply 74. No abstract available. PMID:19422107

HBOC-201, hemoglobin glutamer-250 (bovine), Hemopure (Biopure Corporation)

2008
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Jahr JS, Moallempour M, Lim JC. HBOC-201, hemoglobin glutamer-250 (bovine), Hemopure (Biopure Corporation). Expert Opin Biol Ther. 2008 Sep;8(9):1425-33. doi: 10.1517/14712598.8.9.1425 . Review. PMID:18694360

Metanalysis critical of blood alternative product challenged

2008
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Bateman C. Metanalysis critical of blood alternative product challenged. S Afr Med J. 2008 Oct;98(10):746, 748. No abstract available. PMID:19115744

Modern Cross-linking Strategies for Synthesizing Acellular Hemoglobin-Based Oxygen Carriers

2008
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Harris DR, Palmer AF. Modern cross-linking strategies for synthesizing acellular hemoglobin-based oxygen carriers. Biotechnol Prog. 2008 Nov-Dec;24(6):1215-25. doi: 10.1002/btpr.85. Review. PMID:19194934 | PMCID:PMC2637476

HBOC-201: the multi-purpose oxygen therapeutic

2008
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Dubé GP, Vranckx P, Greenburg AG. HBOC-201: the multi-purpose oxygen therapeutic. EuroIntervention. 2008 May;4(1):161-5. Review. PMID:19112795

Effects of Hemopure on maximal oxygen uptake and endurance performance in healthy humans

2007
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Ashenden MJ, Schumacher YO, Sharpe K, Varlet-Marie E, Audran M. Effects of Hemopure on maximal oxygen uptake and endurance performance in healthy humans. Int J Sports Med. 2007 May;28(5):381-5. Epub 2006 Oct 6. PMID:17024639

Blood substitutes as pharmacotherapies in clinical practice

2007
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ahr JS, Walker V, Manoochehri K. Blood substitutes as pharmacotherapies in clinical practice. Curr Opin Anaesthesiol. 2007 Aug;20(4):325-30. Review. PMID:17620840

Artificial oxygen carriers: a current review

2007
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Henkel-Honke T, Oleck M. Artificial oxygen carriers: a current review. AANA J. 2007 Jun;75(3):205-11. Review. PMID:17591302

Hemoglobin-based O2 carrier O2 affinity and capillary inlet pO2 are important factors that influence O2 transport in a capillary

2007
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Dimino ML, Palmer AF. Hemoglobin-based O2 carrier O2 affinity and capillary inlet pO2 are important factors that influence O2 transport in a capillary. Biotechnol Prog. 2007 Jul-Aug;23(4):921-31. Epub 2007 Jun 8. PMID:17555329 | PMCID:PMC2533853

A comparison of the acute hemodynamic and delayed effects of 50% exchange transfusion with two different cross-linked hemoglobin based oxygen carrying solutions and Pentastarch

2006
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Bonegio RG, Fuhro R, Ragno G, Robert Valeri C, Lieberthal W. A comparison of the acute hemodynamic and delayed effects of 50% exchange transfusion with two different cross-linked hemoglobin based oxygen carrying solutions and Pentastarch. Artif Cells Blood Substit Immobil Biotechnol. 2006;34(2):145-57. PMID:16537171

Acute and long-term effects of modified hemoglobin (HBOC-201) in a rat model of hypertension and chronic kidney disease

2006
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Baylis C. Acute and long-term effects of modified hemoglobin (HBOC-201) in a rat model of hypertension and chronic kidney disease. Transfusion. 2006 Jul;46(7):1104-11. PMID:16836556

Oxygen radical formation does not have an impact in the treatment of severe acute experimental pancreatitis using free cellular hemoglobin

2006
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treatment of severe acute experimental pancreatitis using free cellular hemoglobin. World J Gastroenterol. 2006 May 14;12(18):2914-8. PMID:16718818 | PMCID:PMC4087810

Improvement of impaired microcirculation and tissue oxygenation by hemodilution with hydroxyethyl starch plus cell-free hemoglobin in acute porcine pancreatitis

2006
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Freitag M, Standl TG, Kleinhans H, Gottschalk A, Mann O, Rempf C, et al. Improvement of impaired microcirculation and tissue oxygenation by hemodilution with hydroxyethyl starch plus cell-free hemoglobin in acute porcine pancreatitis.Pancreatology. 2006;6(3):232-9. Epub 2006 Mar 9. PMID:16534248

Structural and functional characterization of glutaraldehyde-polymerized bovine hemoglobin and its isolated fractions

2005
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Buehler PW, Boykins RA, Jia Y, Norris S, Freedberg DI, Alayash AI. Structural and functional characterization of glutaraldehyde-polymerized bovine hemoglobin and its isolated fractions. Anal Chem. 2005 Jun 1;77(11):3466-78. PMID:15924377

Hemopure's process demonstrates TSE and viral clearance

2005
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Laccetti A, Bagai J, Gawryl MS, Light WR. Hemopure's process demonstrates TSE and viral clearance. Dev Biol (Basel). 2005;120:35-6. No abstract available. PMID:16050153

Microcirculatory function and tissue damage is improved after therapeutic injection of bovine hemoglobin in severe acute rodent pancreatitis

2005
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Strate T, Mann O, Kleinhans H, Rusani S, Schneider C, Yekebas E, et al. Microcirculatory function and tissue damage is improved after therapeutic injection of bovine hemoglobin in severe acute rodent pancreatitis. Pancreas. 2005 Apr;30(3):254-9. PMID:15782104

Enhanced central organ oxygenation after application of bovine cell-free hemoglobin HBOC-201

2005
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Freitag M, Standl TG, Gottschalk A, Burmeister MA, Rempf C, Horn EP, et al. Enhanced central organ oxygenation after application of bovine cell-free hemoglobin HBOC-201. Can J Anaesth. 2005 Nov;52(9):904-14. PMID:16251554

Detection of hemoglobin-based oxygen carriers in human serum for doping analysis: screening by electrophoresis

2004
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Lasne F, Crepin N, Ashenden M, Audran M, de Ceaurriz J. Detection of hemoglobin-based oxygen carriers in human serum for doping analysis: screening by electrophoresis. Clin Chem. 2004 Feb;50(2):410-5. Epub 2003 Nov 21. PMID:14633908

Confirmation and quantification of hemoglobin-based oxygen carriers in equine and human plasma by hyphenated liquid chromatography tandem mass spectrometry

2004
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Citation

Guan F, Uboh CE, Soma LR, Luo Y, Jahr JS, Driessen B. Confirmation and quantification of hemoglobin-based oxygen carriers in equine and human plasma by hyphenated liquid chromatography tandem mass spectrometry. Anal Chem. 2004 Sep 1;76(17):5127-35. PMID:15373452

Detection of hemoglobin-based oxygen carriers in human serum for doping analysis: confirmation by size-exclusion HPLC

2004
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Varlet-Marie E, Ashenden M, Lasne F, Sicart MT, Marion B, de Ceaurriz J, et al. Detection of hemoglobin-based oxygen carriers in human serum for doping analysis: confirmation by size-exclusion HPLC. Clin Chem. 2004 Apr;50(4):723-31. Epub 2004 Feb 5. PMID:14764640

The effect of hemopure on coagulation in clinically relevant concentrations

2004
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James MF, Potgieter HE, Ellis P. The effect of hemopure on coagulation in clinically relevant concentrations. Anesth Analg. 2004 Dec;99(6):1593-7, table of contents. PMID:15562038

Hemoglobin-based oxygen carriers

2004
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Greenburg AG, Kim HW. Hemoglobin-based oxygen carriers. Crit Care. 2004;8 Suppl 2:S61-4. Epub 2004 Jun 14. Review. PMID:15196328 | PMCID:PMC3226150

The use of a hemoglobin-based oxygen-carrying solution (HBOC-201) for extracorporeal membrane oxygenation in a porcine model with acute respiratory distress syndrome

2004
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Henderson CL, Anderson CM, Sorrells DL, Wilson BJ, Dick EJ, DiGeronimo RJ. The use of a hemoglobin-based oxygen-carrying solution (HBOC-201) for extracorporeal membrane oxygenation in a porcine model with acute respiratory distress syndrome. Pediatr Crit Care Med. 2004 Jul;5(4):384-90. PMID:15215011

Hope for reducing SA's trauma deaths?

2004
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Bateman C. Hope for reducing SA's trauma deaths? S Afr Med J. 2004 Sep;94(9):728-9. No abstract available. PMID:15487829

Hemoglobin substitutes

2004
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Anbari KK, Garino JP, Mackenzie CF. Hemoglobin substitutes. Eur Spine J. 2004 Oct;13 Suppl 1:S76-82. Epub 2004 May 27. Review. PMID:15168238 | PMCID:PMC3592184

Does lead interfere with hemoglobin-based oxygen carrier (HBOC) function? A pilot study of lead concentrations in three approved or tested HBOCs and oxyhemoglobin dissociation with HBOCs and/or bovine blood with varying lead concentrations

2003
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Citation

Khan AK, Jahr JS, Nesargi S, Rothenberg SJ, Tang Z, Cheung A, et al. Does lead interfere with hemoglobin-based oxygen carrier (HBOC) function? A pilot study of lead concentrations in three approved or tested HBOCs and oxyhemoglobin dissociation with HBOCs and/or bovine blood with varying lead concentrations. Anesth Analg. 2003 Jun;96(6):1813-20, table of contents. PMID:12761018

The pharmacology of tissue oxygenation by biopure's hemoglobin-based oxygen carrier, Hemopure (HBOC-201)

2003
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Pearce LB, Gawryl MS. The pharmacology of tissue oxygenation by biopure's hemoglobin-based oxygen carrier, Hemopure (HBOC-201). Adv Exp Med Biol. 2003;530:261-70. PMID:14562723

The effect of the bovine hemoglobin oxygen therapeutic HBOC-201 on human neutrophil activation in vitro

2003
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Ortegon DP, Dixon PS, Crow KK, Mueller DL, Kerby JD. The effect of the bovine hemoglobin oxygen therapeutic HBOC-201 on human neutrophil activation in vitro. J Trauma. 2003 Oct;55(4):755-60; discussion 760-1. PMID:14566134

Hemoglobin-based oxygen carrier HBOC-201 provides higher and faster increase in oxygen tension in skeletal muscle of anemic dogs than do stored red blood cells

2003
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Standl T, Freitag M, Burmeister MA, Horn EP, Wilhelm S, Am Esch JS. Hemoglobin-based oxygen carrier HBOC-201 provides higher and faster increase in oxygen tension in skeletal muscle of anemic dogs than do stored red blood cells. J Vasc Surg. 2003 Apr;37(4):859-65. PMID:12663989

The polymerized bovine hemoglobin-based oxygen-carrying solution (HBOC-201) is not toxic to neural cells in culture

2002
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Ortegon DP, Davis MR, Dixon PS, Smith DL, Josephs JD, Mueller DL, et al. The polymerized bovine hemoglobin-based oxygen-carrying solution (HBOC-201) is not toxic to neural cells in culture. J Trauma. 2002 Dec;53(6):1068-72. PMID:12478030

Effects of hemoglobin glutamer-250 (bovine) (HBOC-201, Hemopure) on coagulation testing

2002
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Jahr JS, Lurie F, Gosselin R, Lin JS, Wong L, Owings JT, Larkin E. Effects of hemoglobin glutamer-250 (bovine) (HBOC-201, Hemopure) on coagulation testing. Am J Ther. 2002 Sep-Oct;9(5):431-6. PMID:12237736

The HemoCue, a point of care B-hemoglobin photometer, measures hemoglobin concentrations accurately when mixed in vitro with canine plasma and three hemoglobin-based oxygen carriers (HBOC)

2002
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Jahr JS, Lurie F, Driessen B, Davis JA, Gosselin R, Gunther RA. The HemoCue, a point of care B-hemoglobin photometer, measures hemoglobin concentrations accurately when mixed in vitro with canine plasma and three hemoglobin-based oxygen carriers (HBOC). Can J Anaesth. 2002 Mar;49(3):243-8. PMID:11861341

Oxygen therapeutics--current concepts

2001
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Hill SE. Oxygen therapeutics--current concepts. Can J Anaesth. 2001 Apr;48(4 Suppl):S32-40. PMID:11336435.

Haemoglobin-based erythrocyte transfusion substitutes

2001
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Standl T. Haemoglobin-based erythrocyte transfusion substitutes. Expert Opin Biol Ther. 2001 Sep;1(5):831-43. Review. PMID:11728218

Blood product from cattle wins approval for use in humans

2001
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Lok C. Blood product from cattle wins approval for use in humans. Nature. 2001 Apr 19;410(6831):855. No abstract available. PMID:11309575

Transcranial Doppler sonography mean flow velocity during infusion of ultrapurified bovine hemoglobin

1998
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Brauer P, Standl T, Wilhelm S, Burmeister MA, Schulte am Esch J. Transcranial Doppler sonography mean flow velocity during infusion of ultrapurified bovine hemoglobin. J Neurosurg Anesthesiol. 1998 Jul;10(3):146-52. PMID:9681402

Bovine hemoglobin. HBOC-201 causes a reduction of the oxygen partial pressure in poststenotic skeletal muscle

1998
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Horn EP, Standl T, Wilhelm S, Jacobs EE, Freitag U, Freitag M, Schulte am Esch J. Bovine hemoglobin. HBOC-201 causes a reduction of the oxygen partial pressure in poststenotic skeletal muscle]. Anaesthesist. 1998 Feb;47(2):116-23. German. PMID:9530461

Effects of a novel hemoglobin-based oxygen carrier on percent oxygen saturation as determined with arterial blood gas analysis and pulse oximetry

1996
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Hughes GS, Francom SF, Antal EJ, Adams WJ, Locker PK, Yancey EP, et al. Effects of a novel hemoglobin-based oxygen carrier on percent oxygen saturation as determined with arterial blood gas analysis and pulse oximetry. Ann Emerg Med. 1996 Feb;27(2):164-9. PMID:8629746

Hematologic effects of a novel hemoglobin-based oxygen carrier in normal male and female subjects

1995
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Hughes GS Jr, Francome SF, Antal EJ, Adams WJ, Locker PK, Yancey EP, Jacobs EE Jr. Hematologic effects of a novel hemoglobin-based oxygen carrier in normal male and female subjects. J Lab Clin Med. 1995 Nov;126(5):444-51. PMID:7595029

Hemoglobin-based oxygen carrier preserves submaximal exercise capacity in humans

1995
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Hughes GS Jr, Yancey EP, Albrecht R, et al. Hemoglobin-based oxygen carrier preserves submaximal exercise capacity in humans. Clin Pharmacol Ther. 1995 Oct;58(4):434-43. PMID:7586936

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