Organ Perfusion / Transplantation

Metabolic and lipidomic profiling of steatotic human livers during ex situ normothermic machine perfusion guides resuscitation strategies

2020
Organ Perfusion/ Transplantation
Citation

Raigani S, Karimian N, Huang V, Zhang AM, Beijert I, Geerts S, et al. Metabolic and lipidomic profiling of steatotic human livers during ex situ normothermic machine perfusion guides resuscitation strategies. PLoS One. 2020 Jan 24;15(1):e0228011. doi: 10.1371/journal.pone.0228011. eCollection 2020. PubMed PMID: 31978172; PubMed Central PMCID: PMC6980574.

The efficacy of HBOC-201 in ex situ gradual rewarming kidney perfusion in a rat model

2020
Organ Perfusion/ Transplantation
Citation

Mahboub P, Aburawi M, Karimian N, Lin F, Karabacak M, Fontan F, et al. The efficacy of HBOC-201 in ex situ gradual rewarming kidney perfusion in a rat model. Artif Organs. 2020 Jan;44(1):81-90. doi: 10.1111/aor.13534. Epub 2019 Aug 1. PMID:31368159 | PMCID:PMC6916591

Ex-Vivo Normothermic Limb Perfusion With a Hemoglobin-Based Oxygen Carrier Perfusate

2020
Organ Perfusion/ Transplantation
Citation

Said SA, Ordeñana CX, Rezaei M, Figueroa BA, Dasarathy S, Brunengraber H, et al. Ex-Vivo Normothermic Limb Perfusion With a Hemoglobin-Based Oxygen Carrier Perfusate Mil Med. 2020 Jan 7;185(Suppl 1):110-120. https://doi.org/10.1093/milmed/usz314. PubMed PMID: 32074378

Synthetic hemoglobin-based oxygen carriers are an acceptable alternative for packed red blood cells in normothermic kidney perfusion

2019
Organ Perfusion/ Transplantation
Citation

Aburawi MM, Fontan FM, Karimian N, Eymard C, Cronin S, Pendexter C, et al. Synthetic hemoglobin-based oxygen carriers are an acceptable alternative for packed red blood cells in normothermic kidney perfusion. Am J Transplant. 2019 Oct;19(10):2814-2824. doi: 10.1111/ajt.15375. Epub 2019 Apr 26. PubMed PMID: 30938927; PubMed Central PMCID: PMC6763345.

Pretransplant sequential hypo- and normothermic machine perfusion of suboptimal livers donated after circulatory death using a hemoglobin-based oxygen carrier perfusion solution

2019
Organ Perfusion/ Transplantation
Citation

de Vries Y, Matton APM, Nijsten MWN, Werner MJM, van den Berg AP, de Boer MT, et. al. Pretransplant sequential hypo- and normothermic machine perfusion of suboptimal livers donated after circulatory death using a hemoglobin-based oxygen carrier perfusion solution. Am J Transplant. 2019 Apr;19(4):1202-1211. doi: 10.1111/ajt.15228. Epub 2019 Jan 23. PubMed PMID: 30588774; PubMed Central PMCID: PMC6590255.

The impact on the bioenergetic status and oxidative-mediated tissue injury of a combined protocol of hypothermic and normothermic machine perfusion using an acellular haemoglobin-based oxygen carrier: The cold-to-warm machine perfusion of the liver

2019
Organ Perfusion/ Transplantation
Citation

Boteon YL, Laing RW, Schlegel A, Wallace L, Smith A, Attard J, et al. The impact on the bioenergetic status and oxidative-mediated tissue injury of a combined protocol of hypothermic and normothermic machine perfusion using an acellular haemoglobin-based oxygen carrier: The cold-to-warm machine perfusion of the liver. PLoS One. 2019 Oct 23;14(10):e0224066. doi: 10.1371/journal.pone.0224066. eCollection 2019. PMID:31644544 | PMCID:PMC6808429

Restoration of brain circulation and cellular functions hours post-mortem

2019
Organ Perfusion/ Transplantation
Citation

Vrselja Z., Daniele, S.G., Silbereis, J. et al. Restoration of brain circulation and cellular functions hours post-mortem. Nature 568, 336–343 (2019) doi:10.1038/s41586-019-1099-1

Transplantation of High-risk Donor Livers After Ex Situ Resuscitation and Assessment Using Combined Hypo- and Normothermic Machine Perfusion: A Prospective Clinical Trial

2019
Organ Perfusion/ Transplantation
Citation

van Leeuwen OB, de Vries Y, Fujiyoshi M, Nijsten MWN, Ubbink R, Pelgrim GJ, et. al. Transplantation of High-risk Donor Livers After Ex Situ Resuscitation and Assessment Using Combined Hypo- and Normothermic Machine Perfusion: A Prospective Clinical Trial. Ann Surg. 2019 Nov;270(5):906-914. doi: 10.1097/SLA.0000000000003540. PubMed PMID: 31633615.

Transplantation of high-risk donor livers after resuscitation and viability assessment using a combined protocol of oxygenated hypothermic, rewarming and normothermic machine perfusion: study protocol for a prospective, single-arm study (DHOPE-COR-NMP trial)

2019
Organ Perfusion/ Transplantation
Citation

de Vries Y, Berendsen TA, Fujiyoshi M, van den Berg AP, Blokzijl H, de Boer MT, van der Heide F, de Kleine RHJ, van Leeuwen OB, Matton APM, Werner MJM, Lisman T, de Meijer VE, Porte R. Transplantation of high-risk donor livers after resuscitation and viability assessment using a combined protocol of oxygenated hypothermic, rewarming and normothermic machine perfusion: study protocol for a prospective, single-arm study (DHOPE-COR-NMP trial). BMJ Open. 2019 Aug 15;9(8):e028596. doi: 10.1136/bmjopen-2018-028596. PubMed PMID: 31420387; PubMed Central PMCID: PMC6701560.

Renal Protection Against Ischemia Perfusion Injury: Hemoglobin Based Oxygen Carrier-201 vs. Blood as an Oxygen Carrier in Ex vivo Subnormothermic Machine Perfusion

2019
Organ Perfusion/ Transplantation
Citation

Bhattacharjee RN, Patel SVB, Sun Q, Jiang L, Richard-Mohamed M, Ruthirakanthan A, et al.
Renal Protection Against Ischemia Perfusion Injury: Hemoglobin Based Oxygen Carrier-201 vs. Blood as an Oxygen Carrier in Ex vivo Subnormothermic Machine Perfusion. Transplantation. 2019 Sep 18. doi: 10.1097/TP.0000000000002967. [Epub ahead of print] PMID:31568396

Normothermic machine perfusion of donor livers without the need for human blood products

2018
Organ Perfusion/ Transplantation
Citation

Matton APM, Burlage LC, van Rijn R, de Vries Y, Karangwa SA, Nijsten MW, et al. Normothermic machine perfusion of donor livers without the need for human blood products. Liver Transpl. 2018 Apr;24(4):528-538. doi: 10.1002/lt.25005. Erratum in: Liver Transpl. 2018 Aug;24(8):1151. PubMed PMID: 29281862; PubMed Central PMCID: PMC5900573.

The Use of an Acellular Oxygen Carrier in a Human Liver Model of Normothermic Machine Perfusion

2017
Organ Perfusion/ Transplantation
Citation

Laing RW, Bhogal RH, Wallace L, Boteon Y, Neil DAH, Smith A, Stephenson BTF, Schlegel A, Hübscher SG, Mirza DF, Afford SC, Mergental H. The Use of an Acellular Oxygen Carrier in a Human Liver Model of Normothermic Machine Perfusion. Transplantation. 2017 Nov;101(11):2746-2756. doi: 10.1097/TP.0000000000001821. PubMed PMID: 28520579; PubMed Central PMCID: PMC5656179

Liver preservation with machine perfusion and a newly developed cell-free oxygen carrier solution under subnormothermic conditions

2015
Organ Perfusion/ Transplantation
Citation

Fontes P, Lopez R, van der Plaats A, Vodovotz Y, Minervini M, Scott V, et al. Liver preservation with machine perfusion and a newly developed cell-free oxygen carrier solution under subnormothermic conditions. Am J Transplant. 2015 Feb;15(2):381-94. PubMed PMID: 25612645; PubMed Central PMCID: PMC5024042.

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