Organ Perfusion / Transplantation

Comparison of Centrifugal and Pulsatile Perfusion to Preserve Donor Kidneys Using Ex Vivo Subnormothermic Perfusion

Luke PPW, Jiang L, Ruthirakanthan A, Lee D, Sun Q, Richard-Mohamed M, Kwong J, Aquil S, Alogaili R, Haig A, Sener A, Bhattacharjee RN. Comparison of Centrifugal and Pulsatile Perfusion to Preserve Donor Kidneys Using Ex Vivo Subnormothermic Perfusion. J Invest Surg. 2021 Jan 5:1-7. doi: 10.1080/08941939.2020.1829212. Epub ahead of print. PMID: 33400888.

Oxygen Transport during Ex Situ Machine Perfusion of Donor Livers Using Red Blood Cells or Artificial Oxygen Carriers.

Bodewes SB, van Leeuwen OB, Thorne AM, Lascaris B, Ubbink R, Lisman T, Monbaliu D, De Meijer VE, Nijsten MWN, Porte RJ. Oxygen Transport during Ex Situ Machine Perfusion of Donor Livers Using Red Blood Cells or Artificial Oxygen Carriers. Int J Mol Sci. 2020 Dec 28;22(1):235. doi: 10.3390/ijms22010235. PMID: 33379394; PMCID: PMC7795786.

Evaluating the Effects of Subnormothermic Perfusion with AP39 in a Novel Blood-Free Model of Ex Vivo Kidney Preservation and Reperfusion.

Juriasingani S, Jackson A, Zhang MY, Ruthirakanthan A, Dugbartey GJ, Sogutdelen E, Levine M, Mandurah M, Whiteman M, Luke P, Sener A. Evaluating the Effects of Subnormothermic Perfusion with AP39 in a Novel Blood-Free Model of Ex Vivo Kidney Preservation and Reperfusion. International Journal of Molecular Sciences. 2021; 22(13):7180. https://doi.org/10.3390/ijms22137180

Metabolic and lipidomic profiling of steatotic human livers during ex situ normothermic machine perfusion guides resuscitation strategies

Raigani S, Karimian N, Huang V, Zhang AM, Beijert I, Geerts S, et al. Metabolic and lipidomic profiling of steatotic human livers during ex situ normothermic machine perfusion guides resuscitation strategies. PLoS One. 2020 Jan 24;15(1):e0228011. doi: 10.1371/journal.pone.0228011. eCollection 2020. PubMed PMID: 31978172; PubMed Central PMCID: PMC6980574.

The efficacy of HBOC-201 in ex situ gradual rewarming kidney perfusion in a rat model

Mahboub P, Aburawi M, Karimian N, Lin F, Karabacak M, Fontan F, et al. The efficacy of HBOC-201 in ex situ gradual rewarming kidney perfusion in a rat model. Artif Organs. 2020 Jan;44(1):81-90. doi: 10.1111/aor.13534. Epub 2019 Aug 1. PMID:31368159 | PMCID:PMC6916591

Ex-Vivo Normothermic Limb Perfusion With a Hemoglobin-Based Oxygen Carrier Perfusate

Said SA, Ordeñana CX, Rezaei M, Figueroa BA, Dasarathy S, Brunengraber H, et al. Ex-Vivo Normothermic Limb Perfusion With a Hemoglobin-Based Oxygen Carrier Perfusate Mil Med. 2020 Jan 7;185(Suppl 1):110-120. https://doi.org/10.1093/milmed/usz314. PubMed PMID: 32074378

Synthetic hemoglobin-based oxygen carriers are an acceptable alternative for packed red blood cells in normothermic kidney perfusion

Aburawi MM, Fontan FM, Karimian N, Eymard C, Cronin S, Pendexter C, et al. Synthetic hemoglobin-based oxygen carriers are an acceptable alternative for packed red blood cells in normothermic kidney perfusion. Am J Transplant. 2019 Oct;19(10):2814-2824. doi: 10.1111/ajt.15375. Epub 2019 Apr 26. PubMed PMID: 30938927; PubMed Central PMCID: PMC6763345.

Pretransplant sequential hypo- and normothermic machine perfusion of suboptimal livers donated after circulatory death using a hemoglobin-based oxygen carrier perfusion solution

de Vries Y, Matton APM, Nijsten MWN, Werner MJM, van den Berg AP, de Boer MT, et. al. Pretransplant sequential hypo- and normothermic machine perfusion of suboptimal livers donated after circulatory death using a hemoglobin-based oxygen carrier perfusion solution. Am J Transplant. 2019 Apr;19(4):1202-1211. doi: 10.1111/ajt.15228. Epub 2019 Jan 23. PubMed PMID: 30588774; PubMed Central PMCID: PMC6590255.

Transplantation of High-risk Donor Livers After Ex Situ Resuscitation and Assessment Using Combined Hypo- and Normothermic Machine Perfusion: A Prospective Clinical Trial

van Leeuwen OB, de Vries Y, Fujiyoshi M, Nijsten MWN, Ubbink R, Pelgrim GJ, et. al. Transplantation of High-risk Donor Livers After Ex Situ Resuscitation and Assessment Using Combined Hypo- and Normothermic Machine Perfusion: A Prospective Clinical Trial. Ann Surg. 2019 Nov;270(5):906-914. doi: 10.1097/SLA.0000000000003540. PubMed PMID: 31633615.

Restoration of brain circulation and cellular functions hours post-mortem

Vrselja Z., Daniele, S.G., Silbereis, J. et al. Restoration of brain circulation and cellular functions hours post-mortem. Nature 568, 336–343 (2019) doi:10.1038/s41586-019-1099-1

Renal Protection Against Ischemia Perfusion Injury: Hemoglobin Based Oxygen Carrier-201 vs. Blood as an Oxygen Carrier in Ex vivo Subnormothermic Machine Perfusion

Bhattacharjee RN, Patel SVB, Sun Q, Jiang L, Richard-Mohamed M, Ruthirakanthan A, et al.
Renal Protection Against Ischemia Perfusion Injury: Hemoglobin Based Oxygen Carrier-201 vs. Blood as an Oxygen Carrier in Ex vivo Subnormothermic Machine Perfusion. Transplantation. 2019 Sep 18. doi: 10.1097/TP.0000000000002967. [Epub ahead of print] PMID:31568396

Transplantation of high-risk donor livers after resuscitation and viability assessment using a combined protocol of oxygenated hypothermic, rewarming and normothermic machine perfusion: study protocol for a prospective, single-arm study (DHOPE-COR-NMP trial)

de Vries Y, Berendsen TA, Fujiyoshi M, van den Berg AP, Blokzijl H, de Boer MT, van der Heide F, de Kleine RHJ, van Leeuwen OB, Matton APM, Werner MJM, Lisman T, de Meijer VE, Porte R. Transplantation of high-risk donor livers after resuscitation and viability assessment using a combined protocol of oxygenated hypothermic, rewarming and normothermic machine perfusion: study protocol for a prospective, single-arm study (DHOPE-COR-NMP trial). BMJ Open. 2019 Aug 15;9(8):e028596. doi: 10.1136/bmjopen-2018-028596. PubMed PMID: 31420387; PubMed Central PMCID: PMC6701560.

The impact on the bioenergetic status and oxidative-mediated tissue injury of a combined protocol of hypothermic and normothermic machine perfusion using an acellular haemoglobin-based oxygen carrier: The cold-to-warm machine perfusion of the liver

Boteon YL, Laing RW, Schlegel A, Wallace L, Smith A, Attard J, et al. The impact on the bioenergetic status and oxidative-mediated tissue injury of a combined protocol of hypothermic and normothermic machine perfusion using an acellular haemoglobin-based oxygen carrier: The cold-to-warm machine perfusion of the liver. PLoS One. 2019 Oct 23;14(10):e0224066. doi: 10.1371/journal.pone.0224066. eCollection 2019. PMID:31644544 | PMCID:PMC6808429

Normothermic machine perfusion of donor livers without the need for human blood products

Matton APM, Burlage LC, van Rijn R, de Vries Y, Karangwa SA, Nijsten MW, et al. Normothermic machine perfusion of donor livers without the need for human blood products. Liver Transpl. 2018 Apr;24(4):528-538. doi: 10.1002/lt.25005. Erratum in: Liver Transpl. 2018 Aug;24(8):1151. PubMed PMID: 29281862; PubMed Central PMCID: PMC5900573.

The Use of an Acellular Oxygen Carrier in a Human Liver Model of Normothermic Machine Perfusion

Laing RW, Bhogal RH, Wallace L, Boteon Y, Neil DAH, Smith A, Stephenson BTF, Schlegel A, Hübscher SG, Mirza DF, Afford SC, Mergental H. The Use of an Acellular Oxygen Carrier in a Human Liver Model of Normothermic Machine Perfusion. Transplantation. 2017 Nov;101(11):2746-2756. doi: 10.1097/TP.0000000000001821. PubMed PMID: 28520579; PubMed Central PMCID: PMC5656179

Liver preservation with machine perfusion and a newly developed cell-free oxygen carrier solution under subnormothermic conditions

Fontes P, Lopez R, van der Plaats A, Vodovotz Y, Minervini M, Scott V, et al. Liver preservation with machine perfusion and a newly developed cell-free oxygen carrier solution under subnormothermic conditions. Am J Transplant. 2015 Feb;15(2):381-94. PubMed PMID: 25612645; PubMed Central PMCID: PMC5024042.