Organ Perfusion / Transplantation
EX-VIVO LIMB PERFUSION
Meyers A, Duarte-Bateman D, Almalak M, Kopparthy V, Rampazzo A, Gharb BB. EX-VIVO LIMB PERFUSION. European Journal of Transplantation. 2023 Mar 21:143-54.
THE EFFECT OF KIDNEY PRESERVATION AT 10° C WITH HEMOPURE AND HYDROGEN SULFIDE DONOR, SODIUM THIOSULFATE, IN A SYNGENEIC RAT RENAL TRANSPLANTATION MODEL.
Taka MA, Sener A. PD31-06 THE EFFECT OF KIDNEY PRESERVATION AT 10° C WITH HEMOPURE AND HYDROGEN SULFIDE DONOR, SODIUM THIOSULFATE, IN A SYNGENEIC RAT RENAL TRANSPLANTATION MODEL. The Journal of Urology. 2023 Apr;209(Supplement 4):e902.
338.3: Utilization of oxygenated hemopure based University of Wisconsin solution during simulated procurement, back-benching, and graft implantation to minimize ischemic reperfusion injury in a rat liver transplantation simulated on pump.
Kharga A, Chen H, Taggart M, Mojoudi M, Yeh H, Uygun K, Markmann JF. 338.3: Utilization of oxygenated hemopure based University of Wisconsin solution during simulated procurement, back-benching, and graft implantation to minimize ischemic reperfusion injury in a rat liver transplantation simulated on pump. Transplantation. 2023 Oct 1;107(10S2):147-8.
Cellular recovery after prolonged warm ischaemia of the whole body.
Andrijevic D, Vrselja Z, Lysyy T, Zhang S, Skarica M, Spajic A, et al.Nature. 2022 Aug 3. Epub ahead of print.
Improved organ recovery after oxygen deprivation.
Porte RJ. Nature. 2022 Aug 3. Epub ahead of print.
A O03 Ex vivo perfusion of isolated human liver segments: the development of a novel model for ethical, translational research.
Kanani T, Isherwood J, Chung WY, Tang S, Alnabati N, Haigh R, West K, Oggioni MR, Garcea G, Dennison A. A O03 Ex vivo perfusion of isolated human liver segments: the development of a novel model for ethical, translational research. British Journal of Surgery. 2022 Dec 14;109(Supplement_9):znac404-003.
Hemoglobin-Based Oxygen Carriers: Clinical Application of HBOC-201 As an Alternative to Red Blood Cells for Machine Perfusion in Liver Transplantation.
Moein M, Ahmed M, Arafa F, Saidi RF. Hemoglobin-Based Oxygen Carriers: Clinical Application of HBOC-201 As an Alternative to Red Blood Cells for Machine Perfusion in Liver Transplantation. Surgery in Practice and Science. 2022 Aug 20:100120.
The Immunological Effect of Oxygen Carriers on Normothermic Ex Vivo Liver Perfusion.
Jennings H, Carlson KN, Little C, Verhagen JC, Nagendran J, Liu Y, Verhoven B, Zeng W, McMorrow S, Chlebeck P, Al-Adra DP. Front Immunol. 2022 Jun 22;13:833243. doi: 10.3389/fimmu.2022.833243. PMID: 35812402; PMCID: PMC9258194.
Perfusate Composition and Duration of Ex-Vivo Normothermic Perfusion in Kidney Transplantation: A Systematic Review
Fard A, Pearson R, Lathan R, Mark PB, Clancy MJ. Transpl Int. 2022 May 11;35:10236. doi: 10.3389/ti.2022.10236. PMID: 35634582; PMCID: PMC9130468.
Ex vivo normothermic preservation of amputated limbs with a hemoglobin-based oxygen carrier perfusate. Journal of Trauma and Acute Care Surgery. 2022 Feb 1;92(2):388-97.
Figueroa BA, Said SA, Ordenana C, Rezaei M, Orfahli LM, Dubé GP, Papay F, Brunengraber H, Dasarathy S, Rampazzo A, Gharb BB. Ex vivo normothermic preservation of amputated limbs with a hemoglobin-based oxygen carrier perfusate. Journal of Trauma and Acute Care Surgery. 2022 Feb 1;92(2):388-97.
Evaluating the Effects of Subnormothermic Perfusion with AP39 in a Novel Blood-Free Model of Ex Vivo Kidney Preservation and Reperfusion.
Juriasingani S, Jackson A, Zhang MY, Ruthirakanthan A, Dugbartey GJ, Sogutdelen E, Levine M, Mandurah M, Whiteman M, Luke P, Sener A. Evaluating the Effects of Subnormothermic Perfusion with AP39 in a Novel Blood-Free Model of Ex Vivo Kidney Preservation and Reperfusion. International Journal of Molecular Sciences. 2021; 22(13):7180. https://doi.org/10.3390/ijms22137180
Comparison of Centrifugal and Pulsatile Perfusion to Preserve Donor Kidneys Using Ex Vivo Subnormothermic Perfusion
Luke PPW, Jiang L, Ruthirakanthan A, Lee D, Sun Q, Richard-Mohamed M, Kwong J, Aquil S, Alogaili R, Haig A, Sener A, Bhattacharjee RN. Comparison of Centrifugal and Pulsatile Perfusion to Preserve Donor Kidneys Using Ex Vivo Subnormothermic Perfusion. J Invest Surg. 2021 Jan 5:1-7. doi: 10.1080/08941939.2020.1829212. Epub ahead of print. PMID: 33400888.
Oxygen Transport during Ex Situ Machine Perfusion of Donor Livers Using Red Blood Cells or Artificial Oxygen Carriers.
Bodewes SB, van Leeuwen OB, Thorne AM, Lascaris B, Ubbink R, Lisman T, Monbaliu D, De Meijer VE, Nijsten MWN, Porte RJ. Oxygen Transport during Ex Situ Machine Perfusion of Donor Livers Using Red Blood Cells or Artificial Oxygen Carriers. Int J Mol Sci. 2020 Dec 28;22(1):235. doi: 10.3390/ijms22010235. PMID: 33379394; PMCID: PMC7795786.
Ex-Vivo Normothermic Limb Perfusion With a Hemoglobin-Based Oxygen Carrier Perfusate
Said SA, Ordeñana CX, Rezaei M, Figueroa BA, Dasarathy S, Brunengraber H, et al. Ex-Vivo Normothermic Limb Perfusion With a Hemoglobin-Based Oxygen Carrier Perfusate Mil Med. 2020 Jan 7;185(Suppl 1):110-120. https://doi.org/10.1093/milmed/usz314. PubMed PMID: 32074378
The efficacy of HBOC-201 in ex situ gradual rewarming kidney perfusion in a rat model
Mahboub P, Aburawi M, Karimian N, Lin F, Karabacak M, Fontan F, et al. The efficacy of HBOC-201 in ex situ gradual rewarming kidney perfusion in a rat model. Artif Organs. 2020 Jan;44(1):81-90. doi: 10.1111/aor.13534. Epub 2019 Aug 1. PMID:31368159 | PMCID:PMC6916591
Metabolic and lipidomic profiling of steatotic human livers during ex situ normothermic machine perfusion guides resuscitation strategies
Raigani S, Karimian N, Huang V, Zhang AM, Beijert I, Geerts S, et al. Metabolic and lipidomic profiling of steatotic human livers during ex situ normothermic machine perfusion guides resuscitation strategies. PLoS One. 2020 Jan 24;15(1):e0228011. doi: 10.1371/journal.pone.0228011. eCollection 2020. PubMed PMID: 31978172; PubMed Central PMCID: PMC6980574.
The impact on the bioenergetic status and oxidative-mediated tissue injury of a combined protocol of hypothermic and normothermic machine perfusion using an acellular haemoglobin-based oxygen carrier: The cold-to-warm machine perfusion of the liver
Boteon YL, Laing RW, Schlegel A, Wallace L, Smith A, Attard J, et al. The impact on the bioenergetic status and oxidative-mediated tissue injury of a combined protocol of hypothermic and normothermic machine perfusion using an acellular haemoglobin-based oxygen carrier: The cold-to-warm machine perfusion of the liver. PLoS One. 2019 Oct 23;14(10):e0224066. doi: 10.1371/journal.pone.0224066. eCollection 2019. PMID:31644544 | PMCID:PMC6808429
Transplantation of high-risk donor livers after resuscitation and viability assessment using a combined protocol of oxygenated hypothermic, rewarming and normothermic machine perfusion: study protocol for a prospective, single-arm study (DHOPE-COR-NMP trial)
de Vries Y, Berendsen TA, Fujiyoshi M, van den Berg AP, Blokzijl H, de Boer MT, van der Heide F, de Kleine RHJ, van Leeuwen OB, Matton APM, Werner MJM, Lisman T, de Meijer VE, Porte R. Transplantation of high-risk donor livers after resuscitation and viability assessment using a combined protocol of oxygenated hypothermic, rewarming and normothermic machine perfusion: study protocol for a prospective, single-arm study (DHOPE-COR-NMP trial). BMJ Open. 2019 Aug 15;9(8):e028596. doi: 10.1136/bmjopen-2018-028596. PubMed PMID: 31420387; PubMed Central PMCID: PMC6701560.
Renal Protection Against Ischemia Perfusion Injury: Hemoglobin Based Oxygen Carrier-201 vs. Blood as an Oxygen Carrier in Ex vivo Subnormothermic Machine Perfusion
Bhattacharjee RN, Patel SVB, Sun Q, Jiang L, Richard-Mohamed M, Ruthirakanthan A, et al.
Renal Protection Against Ischemia Perfusion Injury: Hemoglobin Based Oxygen Carrier-201 vs. Blood as an Oxygen Carrier in Ex vivo Subnormothermic Machine Perfusion. Transplantation. 2019 Sep 18. doi: 10.1097/TP.0000000000002967. [Epub ahead of print] PMID:31568396
Restoration of brain circulation and cellular functions hours post-mortem
Vrselja Z., Daniele, S.G., Silbereis, J. et al. Restoration of brain circulation and cellular functions hours post-mortem. Nature 568, 336–343 (2019) doi:10.1038/s41586-019-1099-1
Transplantation of High-risk Donor Livers After Ex Situ Resuscitation and Assessment Using Combined Hypo- and Normothermic Machine Perfusion: A Prospective Clinical Trial
van Leeuwen OB, de Vries Y, Fujiyoshi M, Nijsten MWN, Ubbink R, Pelgrim GJ, et. al. Transplantation of High-risk Donor Livers After Ex Situ Resuscitation and Assessment Using Combined Hypo- and Normothermic Machine Perfusion: A Prospective Clinical Trial. Ann Surg. 2019 Nov;270(5):906-914. doi: 10.1097/SLA.0000000000003540. PubMed PMID: 31633615.
Pretransplant sequential hypo- and normothermic machine perfusion of suboptimal livers donated after circulatory death using a hemoglobin-based oxygen carrier perfusion solution
de Vries Y, Matton APM, Nijsten MWN, Werner MJM, van den Berg AP, de Boer MT, et. al. Pretransplant sequential hypo- and normothermic machine perfusion of suboptimal livers donated after circulatory death using a hemoglobin-based oxygen carrier perfusion solution. Am J Transplant. 2019 Apr;19(4):1202-1211. doi: 10.1111/ajt.15228. Epub 2019 Jan 23. PubMed PMID: 30588774; PubMed Central PMCID: PMC6590255.
Synthetic hemoglobin-based oxygen carriers are an acceptable alternative for packed red blood cells in normothermic kidney perfusion
Aburawi MM, Fontan FM, Karimian N, Eymard C, Cronin S, Pendexter C, et al. Synthetic hemoglobin-based oxygen carriers are an acceptable alternative for packed red blood cells in normothermic kidney perfusion. Am J Transplant. 2019 Oct;19(10):2814-2824. doi: 10.1111/ajt.15375. Epub 2019 Apr 26. PubMed PMID: 30938927; PubMed Central PMCID: PMC6763345.
Normothermic machine perfusion of donor livers without the need for human blood products
Matton APM, Burlage LC, van Rijn R, de Vries Y, Karangwa SA, Nijsten MW, et al. Normothermic machine perfusion of donor livers without the need for human blood products. Liver Transpl. 2018 Apr;24(4):528-538. doi: 10.1002/lt.25005. Erratum in: Liver Transpl. 2018 Aug;24(8):1151. PubMed PMID: 29281862; PubMed Central PMCID: PMC5900573.
The Use of an Acellular Oxygen Carrier in a Human Liver Model of Normothermic Machine Perfusion
Laing RW, Bhogal RH, Wallace L, Boteon Y, Neil DAH, Smith A, Stephenson BTF, Schlegel A, Hübscher SG, Mirza DF, Afford SC, Mergental H. The Use of an Acellular Oxygen Carrier in a Human Liver Model of Normothermic Machine Perfusion. Transplantation. 2017 Nov;101(11):2746-2756. doi: 10.1097/TP.0000000000001821. PubMed PMID: 28520579; PubMed Central PMCID: PMC5656179
Liver preservation with machine perfusion and a newly developed cell-free oxygen carrier solution under subnormothermic conditions
Fontes P, Lopez R, van der Plaats A, Vodovotz Y, Minervini M, Scott V, et al. Liver preservation with machine perfusion and a newly developed cell-free oxygen carrier solution under subnormothermic conditions. Am J Transplant. 2015 Feb;15(2):381-94. PubMed PMID: 25612645; PubMed Central PMCID: PMC5024042.