Hematology/Oncology

Posttransfusion hyperhemolysis is arrested by targeting macrophage activation with novel use of Tocilizumab.

Lee LE, Beeler BW, Graham BC, Cap AP, Win N, Chen F. Posttransfusion hyperhemolysis is arrested by targeting macrophage activation with novel use of Tocilizumab. Transfusion. 2020;60(1):30-35. doi:10.1111/trf.15562

A case study of 10 patients administered HBOC-201 in high doses over a prolonged period: outcomes during severe anemia when transfusion is not an option

Zumberg M, Gorlin J, Griffiths EA, Schwartz G, Fletcher BS, Walsh K, et al. A case study of 10 patients administered HBOC-201 in high doses over a prolonged period: outcomes during severe anemia when transfusion is not an option. Transfusion. 2020 May 1. doi: 10.1111/trf.15778. [Epub ahead of print] PubMed PMID: 32358832

Management of thymoma-associated pure red cell aplasia: A novel use of blood substitute HBOC-201 in a Jehovah's Witness

Rubinstein MM, Goss C, Avecilla ST, et al. Management of thymoma-associated pure red cell aplasia: A novel use of blood substitute HBOC-201 in a Jehovah's Witness. Clin Case Rep. 2019 Dec 26;8(2):289-292. doi: 10.1002/ccr3.2626. eCollection 2020 Feb. PubMed PMID: 32128175; PubMed Central PMCID: PMC7044386.

Successful management of the potentially fatal hyperhaemolysis syndrome of sickle cell anaemia with a regimen including bortezomib and Hemopure

Epstein SS, Hadley TJ. Successful management of the potentially fatal hyperhaemolysis syndrome of sickle cell anaemia with a regimen including bortezomib and Hemopure. J Clin Pharm Ther. 2019 Oct;44(5):815-818. doi: 10.1111/jcpt.12998. Epub 2019 Jun 25. PMID:31237703

Use of the blood substitute HBOC-201 in critically ill patients during sickle crisis: a three-case series

Davis JM, El-Haj N, Shah NN, Schwartz G, Block M, Wall J, Tidswell M, DiNino E. Use of the blood substitute HBOC-201 in critically ill patients during sickle crisis: a three-case series. Transfusion. 2018 Jan;58(1):132-137. doi:10.1111/trf.14386. Epub 2017 Oct 26. PubMed PMID: 29076161.

Difficult to swallow: warm autoimmune hemolytic anemia in a Jehovah's Witness treated with hemoglobin concentrate complicated by achalasia

Epperla N, Strouse C, VanSandt AM, Foy P. Difficult to swallow: warm autoimmune hemolytic anemia in a Jehovah's Witness treated with hemoglobin concentrate complicated by achalasia. Transfusion. 2016 Jul;56(7):1801-6. doi: 10.1111/trf.13607. Epub 2016 Apr 6. PMID:27062564

Management of acute anemia in a Jehovah's Witness patient with acute lymphoblastic leukemia with polymerized bovine hemoglobin-based oxygen carrier: a case report

Donahue LL, Shapira I, Shander A, Kolitz J, Allen S, Greenburg G. Management of acute anemia in a Jehovah's Witness patient with acute lymphoblastic leukemia with polymerized bovine hemoglobin-based oxygen carrier: a case report and review of literature. Transfusion. 2010 Jul;50(7):1561-7. doi: 10.1111/j.1537-2995.2010.02603.x. Epub 2010 Apr 23. Review. PMID:20456679

Bovine Blood and Neuromuscular Paralysis as a Bridge to Recovery in a Patent with Severe Autoimmune Hemolytic Anemia

Pachinburavan M, Marik PE. Bovine blood and neuromuscular paralysis as a bridge to recovery in a patient with severe autoimmune hemolytic anemia. Clin Transl Sci. 2008 Sep;1(2):172-3. doi: 10.1111/j.1752-8062.2008.00006.x. PMID:20443842 | PMCID:PMC5439555

Hemoglobin-based oxygen carrier enhanced tumor oxygenation: a novel strategy for cancer therapy

Gundersen SI, Palmer AF. Hemoglobin-based oxygen carrier enhanced tumor oxygenation: a novel strategy for cancer therapy. Biotechnol Prog. 2008 Nov-Dec;24(6):1353-64. doi: 10.1002/btpr.56. PMID:19194950

Bovine hemoglobin (glutamer-250, Hemopure)-specific immunoglobulin G antibody cross-reacts with human hemoglobin but does not lyse red blood cells in vitro

Hamilton RG, Kickler TS. Bovine hemoglobin (glutamer-250, Hemopure)-specific immunoglobulin G antibody cross-reacts with human hemoglobin but does not lyse red blood cells in vitro. Transfusion. 2007 Apr;47(4):723-8. PMID:17381632

Hemopure transfusion in a child with severe anemia

Stefan DC, Uys R, Wessels G. Hemopure transfusion in a child with severe anemia. Pediatr Hematol Oncol. 2007 Jun;24(4):269-73. PMID:17613869.

Influence of the hemoglobin solution HBOC-201 on tissue oxygenation in the rat R1H-tumor

Gottschalk A, Raabe A, Hommel M, Rempf C, Freitag M, Standl T. Influence of the hemoglobin solution HBOC-201 on tissue oxygenation in the rat R1H-tumor. Artif Cells Blood Substit Immobil Biotechnol. 2005;33(4):379-89. PMID:16317957

Long-term transfusion of polymerized bovine hemoglobin in a Jehovah's Witness following chemotherapy for myeloid leukemia: a case report

Agrawal YP, Freedman M, Szczepiorkowski ZM. Long-term transfusion of polymerized bovine hemoglobin in a Jehovah's Witness following chemotherapy for myeloid leukemia: a case report. Transfusion. 2005 Nov;45(11):1735-8. PMID:16271098

Transfusions of Polymerized Bovine Hemoglobin in a Patient with Severe Autoimmune Hemolytic Anemia

Mullon J, Giacoppe G, Clagett C, McCune D, Dillard T. Transfusions of polymerized bovine hemoglobin in a patient with severe autoimmune hemolytic anemia. N Engl J Med. 2000 Jun 1;342(22):1638-43. No abstract available. PMID:10836875

A phase I/II study of polymerized bovine hemoglobin in adult patients with sickle cell disease not in crisis at the time of study

Gonzalez P, Hackney AC, Jones S, Strayhorn D, Hoffman EB, Hughes G, et al. A phase I/II study of polymerized bovine hemoglobin in adult patients with sickle cell disease not in crisis at the time of study. J Investig Med. 1997 Jun;45(5):258-64. PMID:9249998