Hematology/Oncology

A case study of 10 patients administered HBOC-201 in high doses over a prolonged period: outcomes during severe anemia when transfusion is not an option

2020
Hematology/Oncology
Citation

Zumberg M, Gorlin J, Griffiths EA, Schwartz G, Fletcher BS, Walsh K, et al. A case study of 10 patients administered HBOC-201 in high doses over a prolonged period: outcomes during severe anemia when transfusion is not an option. Transfusion. 2020 May 1. doi: 10.1111/trf.15778. [Epub ahead of print] PubMed PMID: 32358832

Safety of bloodless autologous stem cell transplantation in Jehovah's Witness patients

2020
Hematology/Oncology
Citation

Beck A, Lin R, Reza Rejali A, et al. Safety of bloodless autologous stem cell transplantation in Jehovah's Witness patients [published online ahead of print, 2020 Jan 2]. Bone Marrow Transplant. 2020;10.1038/s41409-019-0777-9. doi:10.1038/s41409-019-0777-9

Posttransfusion hyperhemolysis is arrested by targeting macrophage activation with novel use of Tocilizumab.

2020
Hematology/Oncology
Citation

Lee LE, Beeler BW, Graham BC, Cap AP, Win N, Chen F. Posttransfusion hyperhemolysis is arrested by targeting macrophage activation with novel use of Tocilizumab. Transfusion. 2020;60(1):30-35. doi:10.1111/trf.15562

Successful management of the potentially fatal hyperhaemolysis syndrome of sickle cell anaemia with a regimen including bortezomib and Hemopure

2019
Hematology/Oncology
Citation

Epstein SS, Hadley TJ. Successful management of the potentially fatal hyperhaemolysis syndrome of sickle cell anaemia with a regimen including bortezomib and Hemopure. J Clin Pharm Ther. 2019 Oct;44(5):815-818. doi: 10.1111/jcpt.12998. Epub 2019 Jun 25. PMID:31237703

Management of thymoma-associated pure red cell aplasia: A novel use of blood substitute HBOC-201 in a Jehovah's Witness

2019
Hematology/Oncology
Citation

Rubinstein MM, Goss C, Avecilla ST, et al. Management of thymoma-associated pure red cell aplasia: A novel use of blood substitute HBOC-201 in a Jehovah's Witness. Clin Case Rep. 2019 Dec 26;8(2):289-292. doi: 10.1002/ccr3.2626. eCollection 2020 Feb. PubMed PMID: 32128175; PubMed Central PMCID: PMC7044386.

Use of the blood substitute HBOC-201 in critically ill patients during sickle crisis: a three-case series

2017
Hematology/Oncology
Citation

Davis JM, El-Haj N, Shah NN, Schwartz G, Block M, Wall J, Tidswell M, DiNino E. Use of the blood substitute HBOC-201 in critically ill patients during sickle crisis: a three-case series. Transfusion. 2018 Jan;58(1):132-137. doi:10.1111/trf.14386. Epub 2017 Oct 26. PubMed PMID: 29076161.

Difficult to swallow: warm autoimmune hemolytic anemia in a Jehovah's Witness treated with hemoglobin concentrate complicated by achalasia

2016
Hematology/Oncology
Citation

Epperla N, Strouse C, VanSandt AM, Foy P. Difficult to swallow: warm autoimmune hemolytic anemia in a Jehovah's Witness treated with hemoglobin concentrate complicated by achalasia. Transfusion. 2016 Jul;56(7):1801-6. doi: 10.1111/trf.13607. Epub 2016 Apr 6. PMID:27062564

Management of acute anemia in a Jehovah's Witness patient with acute lymphoblastic leukemia with polymerized bovine hemoglobin-based oxygen carrier: a case report

2010
Hematology/Oncology
Citation

Donahue LL, Shapira I, Shander A, Kolitz J, Allen S, Greenburg G. Management of acute anemia in a Jehovah's Witness patient with acute lymphoblastic leukemia with polymerized bovine hemoglobin-based oxygen carrier: a case report and review of literature. Transfusion. 2010 Jul;50(7):1561-7. doi: 10.1111/j.1537-2995.2010.02603.x. Epub 2010 Apr 23. Review. PMID:20456679

Hemoglobin-based oxygen carrier enhanced tumor oxygenation: a novel strategy for cancer therapy

2008
Hematology/Oncology
Citation

Gundersen SI, Palmer AF. Hemoglobin-based oxygen carrier enhanced tumor oxygenation: a novel strategy for cancer therapy. Biotechnol Prog. 2008 Nov-Dec;24(6):1353-64. doi: 10.1002/btpr.56. PMID:19194950

Bovine Blood and Neuromuscular Paralysis as a Bridge to Recovery in a Patent with Severe Autoimmune Hemolytic Anemia

2008
Hematology/Oncology
Citation

Pachinburavan M, Marik PE. Bovine blood and neuromuscular paralysis as a bridge to recovery in a patient with severe autoimmune hemolytic anemia. Clin Transl Sci. 2008 Sep;1(2):172-3. doi: 10.1111/j.1752-8062.2008.00006.x. PMID:20443842 | PMCID:PMC5439555

Bovine hemoglobin (glutamer-250, Hemopure)-specific immunoglobulin G antibody cross-reacts with human hemoglobin but does not lyse red blood cells in vitro

2007
Hematology/Oncology
Citation

Hamilton RG, Kickler TS. Bovine hemoglobin (glutamer-250, Hemopure)-specific immunoglobulin G antibody cross-reacts with human hemoglobin but does not lyse red blood cells in vitro. Transfusion. 2007 Apr;47(4):723-8. PMID:17381632

Hemopure transfusion in a child with severe anemia

2007
Hematology/Oncology
Citation

Stefan DC, Uys R, Wessels G. Hemopure transfusion in a child with severe anemia. Pediatr Hematol Oncol. 2007 Jun;24(4):269-73. PMID:17613869.

Influence of the hemoglobin solution HBOC-201 on tissue oxygenation in the rat R1H-tumor

2005
Hematology/Oncology
Citation

Gottschalk A, Raabe A, Hommel M, Rempf C, Freitag M, Standl T. Influence of the hemoglobin solution HBOC-201 on tissue oxygenation in the rat R1H-tumor. Artif Cells Blood Substit Immobil Biotechnol. 2005;33(4):379-89. PMID:16317957

Long-term transfusion of polymerized bovine hemoglobin in a Jehovah's Witness following chemotherapy for myeloid leukemia: a case report

2005
Hematology/Oncology
Citation

Agrawal YP, Freedman M, Szczepiorkowski ZM. Long-term transfusion of polymerized bovine hemoglobin in a Jehovah's Witness following chemotherapy for myeloid leukemia: a case report. Transfusion. 2005 Nov;45(11):1735-8. PMID:16271098

Transfusions of Polymerized Bovine Hemoglobin in a Patient with Severe Autoimmune Hemolytic Anemia

2000
Hematology/Oncology
Citation

Mullon J, Giacoppe G, Clagett C, McCune D, Dillard T. Transfusions of polymerized bovine hemoglobin in a patient with severe autoimmune hemolytic anemia. N Engl J Med. 2000 Jun 1;342(22):1638-43. No abstract available. PMID:10836875

A phase I/II study of polymerized bovine hemoglobin in adult patients with sickle cell disease not in crisis at the time of study

1997
Hematology/Oncology
Citation

Gonzalez P, Hackney AC, Jones S, Strayhorn D, Hoffman EB, Hughes G, et al. A phase I/II study of polymerized bovine hemoglobin in adult patients with sickle cell disease not in crisis at the time of study. J Investig Med. 1997 Jun;45(5):258-64. PMID:9249998

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