Cardiovascular

Selective aortic arch perfusion with fresh whole blood or HBOC-201 reverses hemorrhage-induced traumatic cardiac arrest in a lethal model of noncompressible torso hemorrhage

2019
Cardiovascular
Citation

Hoops HE, Manning JE, Graham TL, McCully BH, McCurdy SL, Ross JD. Selective aortic arch perfusion with fresh whole blood or HBOC-201 reverses hemorrhage-induced traumatic cardiac arrest in a lethal model of noncompressible torso hemorrhage. J Trauma Acute Care Surg. 2019 Aug;87(2):263-273. doi: 10.1097/TA.0000000000002315. PMID:31348400

Bloodless reperfusion with the oxygen carrier HBOC-201 in acute myocardial infarction: a novel platform for cardioprotective probes delivery. Basic Res Cardiol

2017
Cardiovascular
Citation

García-Ruiz JM, Galán-Arriola C, Fernández-Jiménez R, Aguero J, Sánchez-González J, García-Alvarez A, Nuno-Ayala M, Dubé GP, Zafirelis Z, López-Martín GJ, Bernal JA, Lara-Pezzi E, Fuster V, Ibáñez B. Bloodless reperfusion with the oxygen carrier HBOC-201 in acute myocardial infarction: a novel platform for cardioprotective probes delivery. Basic Res Cardiol. 2017 Mar;112(2):17. doi: 10.1007/s00395-017-0605-6. Epub 2017 Feb 10. PubMed PMID: 28188434.

Preoxygenated hemoglobin-based oxygen carrier HBOC-201 annihilates myocardial ischemia during brief coronary artery occlusion in pigs

2010
Cardiovascular
Citation

Te Lintel Hekkert M, Dubé GP, Regar E, de Boer M, Vranckx P, van der Giessen WJ, Serruys PW, Duncker DJ.
Preoxygenated hemoglobin-based oxygen carrier HBOC-201 annihilates myocardial ischemia during brief coronary artery occlusion in pigs. Am J Physiol Heart Circ Physiol. 2010 Mar;298(3):H1103-13. doi: 10.1152/ajpheart.00667.2009. Epub 2010 Jan 8. PMID:20061545

Effects of hemodilution with a hemoglobin-based oxygen carrier (HBOC-201) on ischemia/reperfusion injury in a model of partial warm liver ischemia of the rat

2009
Cardiovascular
Citation

Zapletal C, Bode A, Lorenz MW, Gebhard MM, Golling M. Effects of hemodilution with a hemoglobin-based oxygen carrier (HBOC-201) on ischemia/reperfusion injury in a model of partial warm liver ischemia of the rat. Microvasc Res. 2009 Dec;78(3):386-92. doi: 10.1016/j.mvr.2009.08.005. Epub 2009 Aug 26. PMID:19715706

Administration of bovine polymerized haemoglobin before and during coronary occlusion reduces infarct size in rabbits

2009
Cardiovascular
Citation

Rempf C, Standl T, Schenke K, Chammas K, Gottschalk A, Burmeister MA, et al. Administration of bovine polymerized haemoglobin before and during coronary occlusion reduces infarct size in rabbits. Br J Anaesth. 2009 Oct;103(4):496-504. doi: 10.1093/bja/aep233. Epub 2009 Aug 26. PMID:19710071

Do approved blood substitutes reduce myocardial infarction size: is this the critical question?

2009
Cardiovascular
Citation

Jahr J. Do approved blood substitutes reduce myocardial infarction size: is this the critical question? Br J Anaesth. 2009 Oct;103(4):470-1. doi: 10.1093/bja/aep227. No abstract available. PMID:19749116

Haemodynamic effects, safety, and tolerability of haemoglobin-based oxygen carrier-201 in patients undergoing PCI for CAD

2008
Cardiovascular
Citation

Serruys PW, Vranckx P, Slagboom T, Regar E, Meliga E, de Winter RJ, et al. Haemodynamic effects, safety, and tolerability of haemoglobin-based oxygen carrier-201 in patients undergoing PCI for CAD. EuroIntervention. 2008 Mar;3(5):600-9. PMID:19608488

Proof-of-concept trial to evaluate haemoglobin based oxygen therapeutics in elective percutaneous coronary revascularisation. Rationale, protocol design and haemodynamic results

2008
Cardiovascular
Citation

Meliga E, Vranckx P, Regar E, Kint PP, Duncker DJ, Serruys PW. Proof-of-concept trial to evaluate haemoglobin based oxygen therapeutics in elective percutaneous coronary revascularisation. Rationale, protocol design and haemodynamic results. EuroIntervention. 2008 May;4(1):99-107. PMID:19112786

A polymerized bovine hemoglobin oxygen carrier preserves regional myocardial function and reduces infarct size after acute myocardial ischemia

2006
Cardiovascular
Citation

George I, Yi GH, Schulman AR, Morrow BT, Cheng Y, Gu A, et al. A polymerized bovine hemoglobin oxygen carrier preserves regional myocardial function and reduces infarct size after acute myocardial ischemia. Am J Physiol Heart Circ Physiol. 2006 Sep;291(3):H1126-37. Epub 2006 Apr 14. PMID:16617139

A novel hemoglobin-based blood substitute protects against myocardial reperfusion injury

2005
Cardiovascular
Citation

Caswell JE, Strange MB, Rimmer DM 3rd, Gibson MF, Cole P, Lefer DJ. A novel hemoglobin-based blood substitute protects against myocardial reperfusion injury. Am J Physiol Heart Circ Physiol. 2005 Apr;288(4):H1796-801. PMID:15772335

Cardioprotection before revascularization in ischemic myocardial injury and the potential role of hemoglobin-based oxygen carriers

2005
Cardiovascular
Citation

Burkhoff D, Lefer DJ. Cardioprotection before revascularization in ischemic myocardial injury and the potential role of hemoglobin-based oxygen carriers. Am Heart J. 2005 Apr;149(4):573-9. Review. PMID:15990736

The effects of a polymerized bovine-derived hemoglobin solution in a rabbit model of arterial thrombosis and bleeding

2004
Cardiovascular
Citation

Marret E, Bonnin P, Mazoyer E, Riou B, Jacobs T, Coriat P, Samama CM. The effects of a polymerized bovine-derived hemoglobin solution in a rabbit model of arterial thrombosis and bleeding. Anesth Analg. 2004 Mar;98(3):604-10, table of contents. PMID:14980905

Polymerized bovine hemoglobin solution as a replacement for allogeneic red blood cell transfusion after cardiac surgery: results of a randomized, double-blind trial

2002
Cardiovascular
Citation

Levy JH, Goodnough LT, Greilich PE, Parr GV, Stewart RW, Gratz I, et al. Polymerized bovine hemoglobin solution as a replacement for allogeneic red blood cell transfusion after cardiac surgery: results of a randomized, double-blind trial. J Thorac Cardiovasc Surg. 2002 Jul;124(1):35-42. PMID:12091806

Bovine hemoglobin (HBOC-201) restores tissue oxygen tension during peripheral and coronary artery stenosis under extended hemodilution

2001
Cardiovascular
Citation

Horn EP, Burmeister MA. Bovine hemoglobin (HBOC-201) restores tissue oxygen tension during peripheral and coronary artery stenosis under extended hemodilution. Anasthesiol Intensivmed Notfallmed Schmerzther. 2001 Nov;36 Suppl 2:S117-8. No abstract available. PMID:11753715

Selective aortic arch perfusion with hemoglobin-based oxygen carrier-201 for resuscitation from exsanguinating cardiac arrest in swine

2001
Cardiovascular
Citation

Manning JE, Katz LM, Pearce LB, Batson DN, McCurdy SL, Gawryl MS, et al. Selective aortic arch perfusion with hemoglobin-based oxygen carrier-201 for resuscitation from exsanguinating cardiac arrest in swine.Crit Care Med. 2001 Nov;29(11):2067-74. PMID:11700396

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