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Anton N, Hitzler JK, Kavanagh BP. Treatment of life-threatening post-haemorrhagic anaemia with cell-free haemoglobin solution in an adolescent Jehovah’s Witness. Br J Haematol. 2002 Sep;118;1183–1186.

Arnaud F, Fasipe D, Philbin N, Rice J, Flournoy WS, Ahlers S, McCarron R, Freilich D. Hematology patterns after hemoglobin-based oxygen carrier resuscitation from severe controlled Hemorrhage with prolonged delayed definitive care. Transfusion. 2007;47:2098-2109.

Arnaud F, Hammett M, Asher L, Philbin N, Rice J, Dong F, Pearce B, Flournoy WS, Nicholson C, McCarron R, Freilich D. Effects of bovine polymerized hemoglobin on coagulation in controlled hemorrhagic shock in swine. SHOCK. 2005;24(2)145-152.

Arnaud F, Handrigan M, Hammett M, Philbin N, Rice J, Dong F, Pearce LB, McCarron R, Freilich D. Coagulation patterns following haemoglobin-based oxygen carrier resuscitation in severe uncontrolled haemorrhagic shock in swine. Transfus Med. 2006 Aug;16(4):290-302.

Arnaud F, Philbin N, Rice J, Dong F, McCarron R, Freilich D. Coagulation parameters after fluid resuscitation in severe hemorrhage and brain injury. Crit Care Med. 2005;33(12):A40.

 

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Bateman C. Metanalysis critical of blood alternative product challenged. S Afr Med J. 2008 Oct;98(10):746-8.

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Bonegio RGB, Fuhro R, Ragno G, Valeri CR, Lieberthal W. A comparison of the acute hemodynamic and delayed effects of 50% exchange transfusion with two different cross-linked hemoglobin based oxygen carrying solutions and Pentastarch. Artif Cells Blood Substit and Biotechnol. 2006;34(2):145-157.

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Buehler PW, Alayash AI. All hemoglobin-based oxygen carriers are not created equally. Biochim Biophys Acta. 2008 Oct;1784(10):1378-81. Epub 2008 Jan 3

Burkhoff D, Lefer DJ. Cardioprotection before revascularization in ischemic myocardial injury and the potential role of hemoglobin-based oxygen carriers. Am Heart J 2005;149:573-9.

Burmeister MA, Rempf C, Rehberg S, Standle TG, Rehberg S, Bartsch-Zwemke S, Krause T, Tuszynski S, Gottschalk A, Schulte J. Effects of prophylactic or therapeutic application of bovine haemoglobin HBOC-200 on ischaemia-reperfusion injury following acute coronary ligature in rats. British Journal of Anaesthesia.2005; 95(6); 737-45

 

C

Cabrales P, Tsai AG, Intaglietta M. Increased tissue PO2 and decreased O2 delivery and consumption after 80% exchange transfusion with polymerized hemoglobin. Am J Physiol Heart Circ Physiol. 2004;H2825-H2833.

Cabrales P, Tsai AG, Intaglietta M. Isovolemic exchange transfusion with increasing concentrations of low oxygen affinity hemoglobin solution limits oxygen delivery due to vasoconstriction. Am J Physiol Heart Circ Physiol. 2008 Nov;295(5):H2212-8.

Cabrales P, Tsai AG, Intaglietta M. Isovolemic exchange transfusion with increasing concentrations of low oxygen affinity hemoglobin solution limits oxygen delivery due to vasoconstriction. Am J Physiol Heart Circ Physiol. 2008 Nov;295(5):H2212-8.

Cabrales P, Tsai AG, Intaglietta M. Polymerized bovine hemoglobin can improve small-volume resuscitation from hemorrhagic shock in hamsters. Shock. 2009 Mar;31(3):300-7.

Cabrales P, Tsai AG, Intaglietta M. Polymerized bovine hemoglobin can improve small-volume resuscitation from hemorrhagic shock in hamsters. Shock. 2009 Mar;31(3):300-7.

Callan MB, Rentko VT. Clinical application of a hemoglobin-based oxygen-carrying solution. Vet Clin Small Anim. 2003;33:1277-1293.

Callas DD, Clark TL, Moreira PL, et al. In vitro effects of a novel hemoglobin-based oxygen carrier on routine chemistry, therapeutic drug, coagulation, hematology, and blood bank assays. Clin Chem. 1997;43(9):1744-1748.

Caswell JE, Strange MB, Rimmer DM, Gibson MF, Cole P, Lefer DJ. A novel hemoglobin-based blood substitute protects against myocardial reperfusion injury. Am J Physiol Heart Circ Physiol. 2005 Apr;288:H1796-H1801.

Chan FP, Jahr JS, Driessen B, Daunt DA, Li KC. Validation of in vivo MR measurement of oxygen saturation after resuscitation with a hemoglobin-based oxygen carrier in a rabbit model. Acad Radiol. 2001 Jul;8(7):583-590.

Cheung AT, Duong PL, Driessen B, Chen PC, Jahr JS, Gunther RA. Systemic function, oxygenation and microvascular correlation during treatment of hemorrhagic shock with blood substitutes. Clin Hemorheol Microcirc. 2006;34(1-2):325-334.

Cheung ATW, (Duong) To PL, Chan DM, Ramanujam S, Barbosa MA. Comparison of treatment modalities for hemorrhagic shock. Art. Cell Blood Substit. Immobil. Biotech. 2007;35: 173-190.

Cheung ATW, Driessen B, Jahr JS, Duong PL, Ramanujam S, Chen PCY, Gunther RA. Blood substitute resuscitation as a treatment modality for moderate hypovolemia. Artificial Cell, Blood Substitutes, and Biotechnology. 2004;32(2):189-207.

Cheung ATW, Jahr JS, Driessen B, et al. The effects of hemoglobin glumater-200 (bovine) on the microcirculation in a canine hypovolemia model: a noninvasive computer-assisted intravital microscopy study. Anesth Analg. 2001;93:832-838.

 

D

Day TK. Current development ad use of hemoglobin-based oxygen-carrying (HBOC) solutions. J Vet Emerg Crit Care. 2003;13(2):77-93.

Dimino ML, Palmer AF. Hemoglobin-based O2 carrier O2 affinity and capillary inlet pO2 are important factors that influence O2 transport in a capillary. Biotechnol. Prog. 2007;23:921-931.

Dong F, Hall C, Golech S, Philbin N, Rice J, Gurney J, Arnaud G, Hammet M, Ma X, Flournoy WS, Hong J, Kaplan LJ, Pearce LB, McGwin G, Ahlers S, McCarron R, Freilich D. Immune effects of resuscitation with HBOC-201, a hemoglobin-based oxygen carrier, in swine with moderately severe hemorrhagic shock from controlled hemorrhage. Shock 2006; 25; 50-55

Driessen B, Brainard B. Fluid therapy for the traumatized patient. JVECC 2006;16(4):276-299.

Driessen B, Jahr JS, Lurie F, Golkaryeh MS, Gunther RA. Arterial oxygenation and oxygen delivery after hemoglobin-based oxygen carrier infusion in canine hypovolemic shock: a dose-response study. Crit Care Med. 2003;31(6)1771-79.

Driessen B, Jahr JS, Lurie F, Griffey SM, Gunther RA. Effects of haemoglobin-based oxygen carrier Hemoglobin glutamer-200 (bovine) on intestinal perfusion and oxygenation in a canine hypovolaemia model.Br J Anaesth. 2001;86:683-692.

Driessen B, Jahr JS, Lurie F, Gunther RA. Addition of hemoglobin-based oxygen carrier Hemoglobin Glutamer-200 (bovine) to 6% hetastarch solution improves restoration of hemodynamic parameters but not oxygen delivery in a canine hypovolemic model. American Society of Anesthesiology. 2001;95:A391.Abstract.

Driessen B, Jahr JS, Lurie F, Gunther RA. Effects of isovolemic resuscitation with hemoglobin-based oxygen carrier Hemoglobin glutamer-200 (bovine) on systemic and mesenteric perfusion and oxygenation in a canine model of hemorrhagic shock: a comparison with 6% hetastarch solution and shed blood. Vet Anaesthesia Analg. 2006;33(6):368-380.

Driessen B, Jahr JS, Lurie F, Gunther RA. Inadequacy of low-volume resuscitation with hemoglobin-based oxygen carrier hemoglobin glutamer-200 (bovine) in canine hypovolemia. J Vet Pharmacol Ther.2001;24(1):61-71.

Driessen B, Zarucco L, Gunther RA, Burns PM, Lamb SV, Vincent SE, Boston RA, Jahr JS, Cheung ATW. Effects of low-volume hemoglobin glutamer-200 versus normal saline and arginine vasopressin resuscitation on systemic and skeletal muscle blood flow and oxygenation in a canine hemorrhagic shock model. Crit Care Med 2007;Vol.35,No.9:2101-2109.

Dubé GP, Vranckx P, Greenburg AG. HBOC-201: The multi-purpose oxygen therapeutic. EuroInterv.2008;4:161-5.

Duggan VE, Holbrook TC, Denchant JE, Blaik MA, Ritchey JW. Diagnosis of aorto-iliac thrombosis in a quarter horse foal using Doppler ultrasound and nuclear scintigraphy. J Vet Intern Med 2004;18:753-756.

Dunn JF, Nwaigwe C, Roche M, Zhu H, Grinberg OY, Pearce BP, Gawryl MS. Mitigation of acute hypoxia in brain by infusion of the acellular hemoglobin HBOC-201: a bold MR imaging study. ISOTT Proceedings, 1999:54. Abstract.

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Estep T, Bucci E, Farmer M, Greenburg G, Harrington J, Kim HW, Klein H, Mitchell P, Nemo G, Olsen K, Palmer A, Valeri RC, Winslow R. Basic science focus on blood substitutes: a summary of the NHLBI Division of Blood Diseases and Resources Working Group Workshop, March 1, 2006. Transfusion2008;48:776-782.

Estep TN. Expectations and implications of blood sparing with hemoglobin based oxygen carriers. Artif Cells Blood Substit Immobil Biotechnol. 2007;35(1):93-105.

Estrada RR. Are i-STAT results adversely affected by an artificial blood substitute in vivo? Military Medicine.2006;171(5):381-388.

Estrin MA, Wehausen CE, Jessen CR, Lee JA. Disseminated intravascular coagulation in cats. J Vet Intern Med. 2006;20:1334-1339.

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Farese JP, Carmona D, Collins K, et al. The effect of a hemoglobin-based oxygen carrier on acceptance and lipid peroxidation of free skin grafts in rats. The Journal of Applied Research in Veterinary Medicine.2004;2(1):34-38.

Fielding CL. A hemoglobin-based oxygen carrier solution for the treatment of parasite-induced anemia in a Barbados sheep. JVECC. 2006;16(1):54-57,

Fischer TH, Merricks EP, Nichols TC, Raymer RR, Hayes PM, Pearce LB, Bode AP, Manning JE. The co-infusion of rehydrated, lymphilized platelets with HBOC-201 for hemostasis in dilutional thrombocytopenia. Blood. 2001;98(11):538A. Abstract.

Fitzgerald MC, Chan JY, Ross AW, Liew SM, Butt WW, Baguley D, Salem HH, Russ MK, Deasy C, Martin KE, Mathew JK and Rosenfeld JV. A synthetic haemoglobin-based oxygen carrier and the reversal of cardiac hypoxia secondary to severe anaemia following trauma. Med J Aust 2011; 194 (9): 471-473.

Fitzpatrick CM, Biggs KL, Atkins BZ, Quance-Fitch FJ, Dixon PS, Savage SA, Jenkins DH, Kerby JD. Prolonged low-volume resuscitation with HBOC-201 in a large-animal survival model of controlled hemorrhage. J Trauma. 2005;59:273-283.

Fitzpatrick CM, Dixon PS, Quance-Fitch F, et al. HBOC-201 does not impair wound healing in a rodent model. Journal of Surgical Research. 2006; 130(2):281. (Abstract #328)

Fitzpatrick CM, Savage SA, Kerby JD, Clouse WD, Kashyap VS. Resuscitation with a blood substitute causes vasoconstriction without oxide scavenging in a model of arterial hemorrhage. J Am Coll Surg.2004;199:693-701.

Fleming P, Ferguson E, Townsend E, Lowe KC. Perceptions in transfusion medicine: a pilot field study on risk and ethics for blood and blood substitutes. Artif Cells Blood Substit Immobil Biotechnol. 2007;35:149-156.

Freilich D, Pearce LB, Pitman A, et al. R. HBOC-201 vasoactivity in a phase III clinical trial in orthopedic surgery subjects--extrapolation of potential risk for acute trauma trials. J Trauma. 66: 365-76, 2009.

Freilich D, Pearce LB, Pitman A, Greenburg G, Berzins M, Bebris L, Ahlers S, McCarron R. HBOC-201 vasoactivity in a phase III clinical trial in orthopedic surgery subjects--extrapolation of potential risk for acute trauma trials. J Trauma. 66: 365-76, 2009.

Freitag M, Mann O, Gottschalk A, Strate T, Standl T. Improvement of pancreatic tissue oxygenation by application of the bovine hemoglobin solution HBOC-301 with and without isovolemic hemodilution in swine with severe acute pancreatitis. Anesthesiology. 2004;101:A395.

Freitag M, Standl TG, Gottschalk A, Burmeister MA, Rempf C, Horn EP, Strate T, Schulte am Esch J. Enhanced central organ oxygenation after application of bovine cell-free hemoglobin HBOC-201. Can J Anesth 2005; 52(9): 904-914

Freitag M, Standl TG, Kleinhans H, Gottschalk A, Mann O, Rempf C, Bachman K, Gocht A, Petri S, Izbicki JR, Strate T. Improvement of impaired microcirculation and tissue oxygenation by Hemodilution with hydroxyethyl starch plus cell-free hemoglobin in acute porcine pancreatitis. Pancreatology. 2006;6:232-239.

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Gardner RB, Hart KA, Stokol T, Divers TJ, Flaminio MJBF. Fell poly syndrome in a pony in North America. J Vet Intern Med. 2006;20:198-203.

Gasthuys M, Alves S, Tabet J. N-terminal adducts of bovine hemoglobin with glutaraldehyde in a hemoglobin-based oxygen carrier. Analytical Chemistry. 2005;77(10):3372-3378.

Gasthuys M, Fenaille AS, Tabet JC. Simple identification of a cross-linked hemoglobin by tandem mass spectrometry in human serum. Anal Chem. 2004;76(22):6628-6634.

Gawryl MS, Hamilton RG. Absence of IgE antibody responses to multi-dose IV administration of bovine hemoglobin (Hemopure) in humans. J Allergy Clin Immunol. 2000;105:S34. Abstract.

Gawryl MS, Hamilton RG. Immunologic safety studies of bovine-derived human blood substitute (Hemopure). J Allergy Clin Immunol. 2003;111(2 Suppl):S166. Abstract.

Gawryl MS, Rentko VT, Moon-Massat PF, Pearce LB. Toxicological effects associated with a bovine hemoglobin based oxygen carrier (HBOC-201) for treatment of hypovolemia. Shock. 2003;19(Suppl) A252.Abstract.

George I, Yi GH, Schulman, AR, Cheng Y, Gu A, Zhang G, Oz MC, Burkhoff D, Wang J. A polymerized bovine hemoglobin oxygen carrier preserves regional myocardial function and reduces infarct size after acute myocardial ischemia. Am J Physiol Heart Circ Physiol. 2006;291(3):H1126-H1137.

Gold JR, Divers TJ, deLahunta. Postanesthetic poliomyelopathy in a 7-day-old calf. J Vet Intern Med2005;19:775-778.

Goldberg R, Patino R, Brenner M, Lee J, Mahon S, Mukai D, Kreuter K, Tombert B, Saltzman D. Non-invasive in vivo monitoring of tissue hemoglobin after hemoglobin-based blood substitute infusion in rabbit hypovolemic shock. Crit Care Med 2007 Vol. 35, No. 12 (Suppl) #718

Gonzalez P, Hackney AC, Jones S, Strayhorn D, Hoffman EB, Hughes G, Jacobs EE, Orringer EP. A phase I/II study of polymerized bovine hemoglobin in adult patients with sickle cell disease not in crisis at the time of study. J Investig Med. 1997;45(5):258-264.

Gotshall RW, Hamilton KL, Foreman B, et al. Glutaraldehyde-polymerized bovine hemoglobin and phosphodiesterase-5 inhibition. Crit Care Med. 37:1988-93, 2009.

Guan F, Uboh C, Soma, L, et al. Unique tryptic peptides specific for bovine and human hemoglobin in the detection and confirmation of hemoglobin-based oxygen carriers. Anal Chem. 2004;76(17):5118-5126.

Guan F, Uboh CE, Soma LR, et al. Confirmation and quantification of hemoglobin-based oxygen carriers in equine and human plasma by hyphenated liquid chromatography tandem mass spectrometry. Anal Chem.2004;76(17):5127-5135.

Gurney J, Philbin N, Rice J, Arnaud F, Dong F, Wulster-Radcliffe M, Pearce LB, Kaplan L, McCarron R, Freilich D. A hemoglobin based oxygen carrier, bovine polymerized hemoglobin (HBOC-201) versus hetastarch (HEX) in an uncontrolled liver injury hemorrhagic shock swine model with delayed evacuation. J Trauma. 2004;57:726-738.

 

H

Hall C, Malkevich N, Handrigan, VanderMolen C, Aranaud F, Hong J, Dong F, Rice J, Philbin N, Ahlers S, McCarron R, Freilich D. Innate immune responses in swing resuscitated from severe traumatic hemorrhagiv shock with hemoglobin-based oxygen carrier-201. Art. Cell Blood Substit. Immobil. Biotech. 2007:35:259-274.

Hall RI. The utility of hemoglobin based oxygen carriers (HBOC) – can animal studies help? Can J Anaesth. 2005;52(9):895-898.

Hamilton RG, Kelly N, Gawryl MS, Rentko VT. Absence of immunopathology associated with repeated IV administration of bovine Hb-based oxygen carrier in dogs. Transfusion. 2001;41(2):219-225.

Handrigan MT, Bentley TB, Oliver JD, et al. Choice of fluid influences outcome in prolonged hypotensive resuscitation after hemorrhage in awake rats. Shock 2005; 23; 337-343

Hayward R, Lefer AM. Administration of polymerized bovine hemoglobin improves survival in a rat model of traumatic shock. Methods Find Exp Clin Pharmacol. 1999;21(6):427-433.

Henderson CL, Anderson MD, Sorrells DL, Wilson BJ, Dick EJ, DiGeronimo RJ. The use of a hemoglobin-based oxygen-carrying solution (HBOC-201) for extracorporeal membrane oxygenation in a porcine model with acute respiratory distress syndrome. Pediatr Crit Care Med. 2004;5(4):384-390.

Heneka MT, Loschmann PA, Osswald H. Polymerized hemoglobin restores cardiovascular and kidney function in endotoxin-induced shock in the rat. J Clin Invest. 1997;99(1):47-54.

Hohenhaus AE, Rentko VT. Blood transfusions and blood substitutes. In: DiBartola SP, ed. Fluid Therapy in Small Animal Practice. 2nd ed. Philadelphia, Pa: WB Saunders; 2000:451-464.

Hohenhaus AE. Editorial: Oxyglobin: A transfusion solution. J Vet Intern Med. 2002;16:394-395.

Horn EP, Standl T, Wilhelm S, et al. Bovine hemoglobin HBOC-201 causes a reduction of the oxygen partial pressure in poststenotic skeletal muscle. Anaesthesist. 1998;47(2):116-123. Abstract (English). Article in German.

Horn EP, Standl T, Wilhelm S, Jacobs EE, Freitag U, Freitag M, Schulte am Esch J. Bovine hemoglobin increases skeletal muscle oxygenation during 95% artificial arterial stenosis. Surgery. 1997;121(4):411-418.

Hughes G, Jacobs E, Antal E, et al. Pharmacokinetics of a novel hemoglobin-based oxygen carrier in humans. Crit Care Med. 1995;23(1):A257. Oral Presentations: Pharmacology. Abstract.

I

Irwin DC, Foreman B, Morris K, White M, Sullivan T, Jacobs R, Monnet E, Hackett T, TissotvanPatot MC, Hamilton KL, Gotshall RW. Polymerized bovine hemoglobin decreases oxygen delivery during normoxia and acute hypoxia in the rat. Am J Physiol Heart Circ Physiol. 295:H1090-H1099, 2008.

J

Jacobs EE, Gawryl MS. Tissue oxygen effects of HBOC-201 versus red blood cells. Progress in Applied Microcirculation: Microcirculatory Effects of Hemoglobin Solutions (Book). 2004;Volume 25,pp 16-26, Edited by K. Messmer, K.E. Burhop, J. Hunter. Basel, Karger.

Jacobs EE, Gawryl MS. Use of Hemoglobin Based Oxygen Carrier-201 when blood is not available or not acceptable. Transfusion. 2000;40(S152):41S.

Jahr JS, Liu H, Gull A, Maollempour M, Lim J, Gosselin R. Does HBOC-201 (Hemopure® ) affect platelet function in orthopedic surgery: a single site analysis. Anesth Analg. 2008;106:S-1-S-244. Abstract.

Jahr JS, Lurie F, Bezdikian V, Driessen B, Gunther RA. Measuring Circulating Blood Volume Using Infused Hemoglobin-Based Oxygen Carrier (Oxyglobin®) as an Indicator: Verification in a Canine Hypovolemia Model. Am J Ther. 2008 March/April;15(2):98-101.

Jahr JS, Lurie F, Bezdikian V, et al. Measuring Circulating Blood Volume Using Infused Hemoglobin-Based Oxygen Carrier (Oxyglobin® ) as an Indicator: Verification in a Canine Hypovolemia Model. Am J Ther. 2008 March/April;15(2):98-101.

Jahr JS, Lurie F, Driessen B, et al. The HemoCue, a point of care B-hemoglobin photometer, measures hemoglobin concentrations accurately when mixed in vitro with canine plasma and three hemoglobin-based oxygen carriers (HBOC). Can J Anaesth. 2002 Mar;49(3):243-8.

Jahr JS, Lurie F, Driessen B, Gunther RA, Golkaryeh MS. Comparing arterial oxygen saturation (SaO2) from a Nellcor Oxygen Saturation Monitor, IL Co-Oximeter and (LEXO2CON) with varying concentrations of Hemoglobin-Based Oxygen Carrier (HBOC) in a dog hemorrhage model. American Society of Anesthesiology. 2001;95:A557. Abstract.

Jahr JS, Lurie F, Driessen B, Tang Z, et al. Validation of oxygen saturation measurements in a canine model of hemoglobin based oxygen carrier (HBOC) infusion. Clin Lab Sci. 2000;13(3):173-178.

Jahr JS, Lurie F, Xi S, et al. A novel approach to measuring circulating blood volume: the use of a hemoglobin-based oxygen carrier in a rabbit model. Anesth Analg. 2001 Mar;92(3):609-614.

Jahr JS, Mackenzie C, Pearce LB, et al. HBOC-201 as an alternative to blood transfusion: efficacy and safety evaluation in a multicenter phase III trial in elective orthopedic surgery. J Trauma. 2008 Jun;64(6):1484-97

Jahr JS, Moallempour M, Lim JC. HBOC-201, hemoglobin glutamer-250 (bovine), Hemopure (Biopure Corporation). Expert Opin Biol Ther. 2008 Sep;8(9):1425-33. Review.

Jahr JS, Osgood S, Rothenberg SJ, et al.. Lactate measurement interface by hemoglobin-based oxygen carriers (Oxyglobin, Hemopure and Hemolink). Anesth Analg. 2005;100(2):431-436.

Jahr JS, Stewart LM, Mackenzie C, et al. Pivotal phase III study: safety of polymerized bovine hemoglobin (HBOC-201, Hemopure® ) as compared to RBC in patients undergoing orthopedic surgery. Anesthesiology. 2002;96:A243. Abstract.
Jahr JS, Walker V, Manoochehri K. Blood substitutes as pharmacotherapies in clinical practice. Curr Opin Anaesthesiol. 2007;20:325-330.

Jahr JS; Weeks DL; Desai P; Lim JC; Butch AW; Gunther R; Driessen B. Does OxyVita, a new generation hemoglobin-based oxygen carrier, or Oxyglobin acutely interfere with coagulation compared with normal saline or 6% hetastarch? An ex vivo thromboelastography study. J Cardiothorac Vasc Anesth. 2008;22(1):34-39.

Johnson T, Arnaud F, Dong F, et al. Bovine polymerized hemoglobin (hemoglobin-based oxygen carrier-201) resuscitation in three swine models of hemorrhagic shock with militarily relevant delayed evacuation - effects on histopathology and organ function. Crit Care Med. 2006;34(5):1464-1474.

K

Kahn AK, Jahr JS, Nesargi S, et al. Does lead interfere with hemoglobin-based oxygen carrier (HBOC) function? A pilot study of lead concentrations in three approved or tested HBOCs and oxyhemoglobin dissociation with HBOCs and/or bovine blood with varying lead concentrations. Anesth Analg. 2003;96:1813-20.

Kaplan LJ, Philbin N, Arnaud F, Rice J, Dong F, Freilich D. Resuscitation from hemorrhagic shock; fluid selectin and infusion strategy drives unmeasured ion genesis. J Trauma, Injury, Infection and Critical Care. 2006;61:90-98.

Kim HW, Hai CM, Greenburg AG. Artif Cells Blood Substit Immobil Biotechnol. 2010 Jan 5. [Epub ahead of print] Relative Roles of Heme-Irons and Globin-Thiols in the Genesis of Acellular Hemoglobin Mediated Vasoconstriction.
Kim HW. Effect of IV HBOC-201 on coronary hemodynamics and function in patients undergoing elective PCI. XIth International Symposium on Blood Substitutes. Beijing, China - October 20, 2007.

King DR, Cohn S, Proctor K. Resuscitation with a hemoglobin-based oxygen carrier after severe brain trauma. Journal of the American College of Surgeons. 2004;199(3 Suppl):45.

King DR, Cohn SM, Proctor KG. Resuscitation with a hemoglobin-based oxygen carrier after traumatic brain injury. J Trauma, Injury, Infection and Critical Care. 2005;59(3):553-562.

Kleinhans H, Mann O, Schurr PG, Kaifi JT, Hansen B, Izbicki JR, Strate T. Oxygen radical formation does not have an impact in the treatment of severe acute experimental pancreatitis using free cellular hemoglobin. World J Gastroenterol. 2006 May 14; 12(18): 2914-2918.

Knudson MM, Lee S, Erickson V, Morabito D, Derugin N, Manley GT. Tissue oxygen monitoring during Hemorrhagic shock and resuscitation: A comparison of lactated ringer's solution, hypertonic saline dextran and HBOC-201. J Trauma, Injury, Infection and Critical Care. 2003;54:242-52.

Koch T, Duncker HP, Heller A, Schaible R, Van Ackern K, Neuhof H. Effects of stroma-free hemoglobin solutions on pulmonary vascular resistance and mediator release in the isolated perfused rabbit lung. Shock. 1994;1(2):146-152.

Kubulus D, Rensing H, Paxian M,et al. Influence of heme-based solutions on stress protein expression and organ failure after hemorrhagic shock. Crit Care Med. 2005;33:629-637.

Kunicka J, Malin M, Zelmanovic D, et al. Automated Quantitation of Hemoglobin-Based Blood Substitutes in Whole Blood Samples. Am JClin Pathol 2001;116:913-919.

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Laccetti A, Baqai J, Gawryl MS, Light WR. Hemopure's process demonstrates TSE and viral clearance. Vyas GN, Williams AE (eds.) Advances in Transfusion Safety. Dev Biol (Basel), Karger. 2005;120:35-36.

LaMuraglia GM, O'Hara PJ, Baker WH, Naslund TC, Norris EJ, Li J, Vandermeersch E. The reduction of the allogenic transfusion requirement in aortic surgery with hemoglobin-based solution. J Vasc Surg. 2000;31(2):299-308.

Lasne F, Crepin N, Ashenden M, et al. J. Detection of hemoglobin-based oxygen carriers in human serum for doping analysis: screening by electrophoresis. Clin Chem. 2004;50(2):410-415.

Lee SK, Morabito D, Hemphill JC, Erickson V, Holcroft JJ, Derugin N, Knudson MM, Manley GT. Small-volume resuscitation with HBOC-201: Effects on cardiovascular parameters and brain tissue oxygen tension in an out-of-hospital model of hemorrhage in swine. Acad Emerg Med. 2002;9(10);969-976.

Levien LJ. Bovine hemoglobin (Hemopure): Clinical Use in South Africa. Accepted for oral presentation at the Xth International Symposium on Blood Substitutes, Brown University, Providence, RI, June 14, 2005, abstract.

Levien LJ. Clinical Use of Hemopure (HBOC 201) in South Africa. Presented at the Annual Meeting of the Vascular Society of Southern Africa. Stellenbosch, South Africa. October 2003 Abstract.

Levien LJ. Clinical Use of Hemopure (HBOC 201) in South Africa. Presented at the Controversies and Problems in Surgery IX Symposium. University of Pretoria, South Africa. October 2003 Abstract.

Levien LJ. South Africa: clinical experience with Hemopure. ISBT Science Series.2006;1:167-173.

Levy J. The use of haemoglobin glutamer-250 (HBOC-201) as an oxygen bridge in patients with acute anaemia associated with surgical blood loss. Expert Opin Biol Ther. 2003;3(3):509-517.

Levy JH, Goodnough LT, Greilich P, Pet al. A room-temperature stable hemoglobin (HBOC-201) eliminates allogeneic red blood cell (RBC) transfusion in post-operative cardiac surgery patients. Circulation. 1998;17(Suppl 1):132. Abstract.

Levy JH, Goodnough LT, Greilich PE, et al. Polymerized bovine hemoglobin solution as a replacement for allogeneic red blood cell transfusion after cardiac surgery: Results of a randomized, double-blind trial. J Thorac Cardiovasc Surg. 2002;124(1):35-42.

Lichtenberger, M. Transfusion medicine in exotic pets. Clinical Techniques in Small Animal Practice. 2004;19(2):88-95.

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Ortegon DP, Dixon PS, Crow KK, Mueller DL, Kerby JD. The effect of the bovine hemoglobin oxygen therapeutic HBOC-201 on human neutrophil activation in vitro. J Trauma, Injury, Infection and Critical Care. 2003;55(4):755-61.

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Pearce LB, Rentko VT, Moon-Massat PF, et al.. The pharmacokinetics of a hemoglobin-based oxygen carrier, HBOC-201, does not change during second trimester pregnancy. Acad Emerg Med. 2003; Volume 10, Number 5:494.

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Rempf C, Standl T, Schenke K, Chammas K, Gottschalk A, Burmeister MA, Gottschalk A. Administration of bovine polymerized haemoglobin before and during coronary occlusion reduces infarct size in rabbits. Br J Anaesth. 103: 470-1, 2009.

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Rentko, VT, Pearce LB, Moon-Massat PF, Hansen BJ, Gawryl MS. Pharmacokinetics of low doses of a hemoglobin-based O2 carrier in dogs with normovolemic anemia. JVIM. 2003;17(3):407(A114) Abstract.

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Rice J, Philbin N, Handrigan M, Hall C, McGwin G, Ahlers S, Pearce L B, Arnaud F, McCarron R, Freilich D. Vasoactivity of bovine polymerized hemoglobin (HBOC-201) in swine with traumatic hemorrhagic shock with and without brain injury. J Trauma. 2006; 61(5): 1085-1099.

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Rivera-Chavez FA, Brown RJ, Minei JP. Hypertonic HBOC-201 reduces the systemic and pulmonary hypertension observed with standard HBOC-201. American Association for the Surgery of Trauma (AAST). Presented at the 2005 Annual Meeting of the American Association for the Surgery of Trauma, Atlanta, GA. September 22-24, 2005.

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Wu. J, Hutchings A, Rodriguez C, He J, Moon-Massat P, Rue L III, Kerby J. HBOC may attenuate inflammation by constraining the late-acting inflammatory protein Hmgb-1 in an acute hemorrhage model. XIth International Symposium on Blood Substitutes Beijing, China - October 20, 2007

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