Agrawal YP, Freedman M, Szczepiorkowski ZM. Long-term transfusion of polymerized bovine hemoglobin in a Jehovah's Witness following chemotherapy for myeloid leukemia: a case report. Transfusion. 2005;45(11):1735-1738.
Anton N, Hitzler JK, Kavanagh BP. Treatment of life-threatening post-haemorrhagic anaemia with cell-free haemoglobin solution in an adolescent Jehovah’s Witness. Br J Haematol. 2002 Sep;118;1183–1186.
Arnaud F, Fasipe D, Philbin N, Rice J, Flournoy WS, Ahlers S, McCarron R, Freilich D. Hematology patterns after hemoglobin-based oxygen carrier resuscitation from severe controlled Hemorrhage with prolonged delayed definitive care. Transfusion. 2007;47:2098-2109.
Arnaud F, Hammett M, Asher L, Philbin N, Rice J, Dong F, Pearce B, Flournoy WS, Nicholson C, McCarron R, Freilich D. Effects of bovine polymerized hemoglobin on coagulation in controlled hemorrhagic shock in swine. SHOCK. 2005;24(2)145-152.
Arnaud F, Handrigan M, Hammett M, Philbin N, Rice J, Dong F, Pearce LB, McCarron R, Freilich D. Coagulation patterns following haemoglobin-based oxygen carrier resuscitation in severe uncontrolled haemorrhagic shock in swine. Transfus Med. 2006 Aug;16(4):290-302.
Arnaud F, Philbin N, Rice J, Dong F, McCarron R, Freilich D. Coagulation parameters after fluid resuscitation in severe hemorrhage and brain injury. Crit Care Med. 2005;33(12):A40.
Bateman C. Metanalysis critical of blood alternative product challenged. S Afr Med J. 2008 Oct;98(10):746-8.
Baylis, C. Acute and long-term effects of modified hemoglobin (HBOC-201) in a rat model of hypertension and chronic kidney disease. Transfusion. 2006;46(7):1104-1111.
Bonaventura C, Henkins R, Alayash AI, Crumbliss AL. Allosteric effects on oxidative and nitrosative reactions of cell-free hemoglobins. IUBMB Life Aug - Sep 2007;59(8-9):498-505.
Bonegio RGB, Fuhro R, Ragno G, Valeri CR, Lieberthal W. A comparison of the acute hemodynamic and delayed effects of 50% exchange transfusion with two different cross-linked hemoglobin based oxygen carrying solutions and Pentastarch. Artif Cells Blood Substit and Biotechnol. 2006;34(2):145-157.
Braden TD, Tvedten HW, DeCamp CE, et al. Radiographic, biomechanical, and pathologic effects of hemoglobin glutamer-200 in dogs undergoing cemented total hip arthroplasty. Am J Vet Res.1999;60(11):1337-1340.
Brauer P, Standl T, Wilhelm S, Burmeister MA, Schulte am Esch J. Transcranial Doppler sonography mean flow velocity during infusion of ultrapurified bovine hemoglobin. J Neurosurg Anesth. 1998;10(3):146-152.
Breen PH, Isserles SA, Tabac E, Roizen MF, Taitelman UZ. Protective effect of stroma-free methemoglobin during cyanide poisoning in dogs. Anesthesiology. 1996;85(3):555-565.
Buehler PW, Alayash AI. All hemoglobin-based oxygen carriers are not created equally. Biochim Biophys Acta. 2008 Oct;1784(10):1378-81. Epub 2008 Jan 3
Burkhoff D, Lefer DJ. Cardioprotection before revascularization in ischemic myocardial injury and the potential role of hemoglobin-based oxygen carriers. Am Heart J 2005;149:573-9.
Burmeister MA, Rempf C, Rehberg S, Standle TG, Rehberg S, Bartsch-Zwemke S, Krause T, Tuszynski S, Gottschalk A, Schulte J. Effects of prophylactic or therapeutic application of bovine haemoglobin HBOC-200 on ischaemia-reperfusion injury following acute coronary ligature in rats. British Journal of Anaesthesia.2005; 95(6); 737-45
Cabrales P, Tsai AG, Intaglietta M. Increased tissue PO2 and decreased O2 delivery and consumption after 80% exchange transfusion with polymerized hemoglobin. Am J Physiol Heart Circ Physiol. 2004;H2825-H2833.
Cabrales P, Tsai AG, Intaglietta M. Isovolemic exchange transfusion with increasing concentrations of low oxygen affinity hemoglobin solution limits oxygen delivery due to vasoconstriction. Am J Physiol Heart Circ Physiol. 2008 Nov;295(5):H2212-8.
Cabrales P, Tsai AG, Intaglietta M. Isovolemic exchange transfusion with increasing concentrations of low oxygen affinity hemoglobin solution limits oxygen delivery due to vasoconstriction. Am J Physiol Heart Circ Physiol. 2008 Nov;295(5):H2212-8.
Cabrales P, Tsai AG, Intaglietta M. Polymerized bovine hemoglobin can improve small-volume resuscitation from hemorrhagic shock in hamsters. Shock. 2009 Mar;31(3):300-7.
Cabrales P, Tsai AG, Intaglietta M. Polymerized bovine hemoglobin can improve small-volume resuscitation from hemorrhagic shock in hamsters. Shock. 2009 Mar;31(3):300-7.
Callan MB, Rentko VT. Clinical application of a hemoglobin-based oxygen-carrying solution. Vet Clin Small Anim. 2003;33:1277-1293.
Callas DD, Clark TL, Moreira PL, et al. In vitro effects of a novel hemoglobin-based oxygen carrier on routine chemistry, therapeutic drug, coagulation, hematology, and blood bank assays. Clin Chem. 1997;43(9):1744-1748.
Caswell JE, Strange MB, Rimmer DM, Gibson MF, Cole P, Lefer DJ. A novel hemoglobin-based blood substitute protects against myocardial reperfusion injury. Am J Physiol Heart Circ Physiol. 2005 Apr;288:H1796-H1801.
Chan FP, Jahr JS, Driessen B, Daunt DA, Li KC. Validation of in vivo MR measurement of oxygen saturation after resuscitation with a hemoglobin-based oxygen carrier in a rabbit model. Acad Radiol. 2001 Jul;8(7):583-590.
Cheung AT, Duong PL, Driessen B, Chen PC, Jahr JS, Gunther RA. Systemic function, oxygenation and microvascular correlation during treatment of hemorrhagic shock with blood substitutes. Clin Hemorheol Microcirc. 2006;34(1-2):325-334.
Cheung ATW, (Duong) To PL, Chan DM, Ramanujam S, Barbosa MA. Comparison of treatment modalities for hemorrhagic shock. Art. Cell Blood Substit. Immobil. Biotech. 2007;35: 173-190.
Cheung ATW, Driessen B, Jahr JS, Duong PL, Ramanujam S, Chen PCY, Gunther RA. Blood substitute resuscitation as a treatment modality for moderate hypovolemia. Artificial Cell, Blood Substitutes, and Biotechnology. 2004;32(2):189-207.
Cheung ATW, Jahr JS, Driessen B, et al. The effects of hemoglobin glumater-200 (bovine) on the microcirculation in a canine hypovolemia model: a noninvasive computer-assisted intravital microscopy study. Anesth Analg. 2001;93:832-838.
Day TK. Current development ad use of hemoglobin-based oxygen-carrying (HBOC) solutions. J Vet Emerg Crit Care. 2003;13(2):77-93.
Dimino ML, Palmer AF. Hemoglobin-based O2 carrier O2 affinity and capillary inlet pO2 are important factors that influence O2 transport in a capillary. Biotechnol. Prog. 2007;23:921-931.
Dong F, Hall C, Golech S, Philbin N, Rice J, Gurney J, Arnaud G, Hammet M, Ma X, Flournoy WS, Hong J, Kaplan LJ, Pearce LB, McGwin G, Ahlers S, McCarron R, Freilich D. Immune effects of resuscitation with HBOC-201, a hemoglobin-based oxygen carrier, in swine with moderately severe hemorrhagic shock from controlled hemorrhage. Shock 2006; 25; 50-55
Driessen B, Brainard B. Fluid therapy for the traumatized patient. JVECC 2006;16(4):276-299.
Driessen B, Jahr JS, Lurie F, Golkaryeh MS, Gunther RA. Arterial oxygenation and oxygen delivery after hemoglobin-based oxygen carrier infusion in canine hypovolemic shock: a dose-response study. Crit Care Med. 2003;31(6)1771-79.
Driessen B, Jahr JS, Lurie F, Griffey SM, Gunther RA. Effects of haemoglobin-based oxygen carrier Hemoglobin glutamer-200 (bovine) on intestinal perfusion and oxygenation in a canine hypovolaemia model.Br J Anaesth. 2001;86:683-692.
Driessen B, Jahr JS, Lurie F, Gunther RA. Addition of hemoglobin-based oxygen carrier Hemoglobin Glutamer-200 (bovine) to 6% hetastarch solution improves restoration of hemodynamic parameters but not oxygen delivery in a canine hypovolemic model. American Society of Anesthesiology. 2001;95:A391.Abstract.
Driessen B, Jahr JS, Lurie F, Gunther RA. Effects of isovolemic resuscitation with hemoglobin-based oxygen carrier Hemoglobin glutamer-200 (bovine) on systemic and mesenteric perfusion and oxygenation in a canine model of hemorrhagic shock: a comparison with 6% hetastarch solution and shed blood. Vet Anaesthesia Analg. 2006;33(6):368-380.
Driessen B, Jahr JS, Lurie F, Gunther RA. Inadequacy of low-volume resuscitation with hemoglobin-based oxygen carrier hemoglobin glutamer-200 (bovine) in canine hypovolemia. J Vet Pharmacol Ther.2001;24(1):61-71.
Driessen B, Zarucco L, Gunther RA, Burns PM, Lamb SV, Vincent SE, Boston RA, Jahr JS, Cheung ATW. Effects of low-volume hemoglobin glutamer-200 versus normal saline and arginine vasopressin resuscitation on systemic and skeletal muscle blood flow and oxygenation in a canine hemorrhagic shock model. Crit Care Med 2007;Vol.35,No.9:2101-2109.
Dubé GP, Vranckx P, Greenburg AG. HBOC-201: The multi-purpose oxygen therapeutic. EuroInterv.2008;4:161-5.
Duggan VE, Holbrook TC, Denchant JE, Blaik MA, Ritchey JW. Diagnosis of aorto-iliac thrombosis in a quarter horse foal using Doppler ultrasound and nuclear scintigraphy. J Vet Intern Med 2004;18:753-756.
Dunn JF, Nwaigwe C, Roche M, Zhu H, Grinberg OY, Pearce BP, Gawryl MS. Mitigation of acute hypoxia in brain by infusion of the acellular hemoglobin HBOC-201: a bold MR imaging study. ISOTT Proceedings, 1999:54. Abstract.
Estep T, Bucci E, Farmer M, Greenburg G, Harrington J, Kim HW, Klein H, Mitchell P, Nemo G, Olsen K, Palmer A, Valeri RC, Winslow R. Basic science focus on blood substitutes: a summary of the NHLBI Division of Blood Diseases and Resources Working Group Workshop, March 1, 2006. Transfusion2008;48:776-782.
Estep TN. Expectations and implications of blood sparing with hemoglobin based oxygen carriers. Artif Cells Blood Substit Immobil Biotechnol. 2007;35(1):93-105.
Estrada RR. Are i-STAT results adversely affected by an artificial blood substitute in vivo? Military Medicine.2006;171(5):381-388.
Estrin MA, Wehausen CE, Jessen CR, Lee JA. Disseminated intravascular coagulation in cats. J Vet Intern Med. 2006;20:1334-1339.
Farese JP, Carmona D, Collins K, et al. The effect of a hemoglobin-based oxygen carrier on acceptance and lipid peroxidation of free skin grafts in rats. The Journal of Applied Research in Veterinary Medicine.2004;2(1):34-38.
Fielding CL. A hemoglobin-based oxygen carrier solution for the treatment of parasite-induced anemia in a Barbados sheep. JVECC. 2006;16(1):54-57,
Fischer TH, Merricks EP, Nichols TC, Raymer RR, Hayes PM, Pearce LB, Bode AP, Manning JE. The co-infusion of rehydrated, lymphilized platelets with HBOC-201 for hemostasis in dilutional thrombocytopenia. Blood. 2001;98(11):538A. Abstract.
Fitzgerald MC, Chan JY, Ross AW, Liew SM, Butt WW, Baguley D, Salem HH, Russ MK, Deasy C, Martin KE, Mathew JK and Rosenfeld JV. A synthetic haemoglobin-based oxygen carrier and the reversal of cardiac hypoxia secondary to severe anaemia following trauma. Med J Aust 2011; 194 (9): 471-473.
Fitzpatrick CM, Biggs KL, Atkins BZ, Quance-Fitch FJ, Dixon PS, Savage SA, Jenkins DH, Kerby JD. Prolonged low-volume resuscitation with HBOC-201 in a large-animal survival model of controlled hemorrhage. J Trauma. 2005;59:273-283.
Fitzpatrick CM, Dixon PS, Quance-Fitch F, et al. HBOC-201 does not impair wound healing in a rodent model. Journal of Surgical Research. 2006; 130(2):281. (Abstract #328)
Fitzpatrick CM, Savage SA, Kerby JD, Clouse WD, Kashyap VS. Resuscitation with a blood substitute causes vasoconstriction without oxide scavenging in a model of arterial hemorrhage. J Am Coll Surg.2004;199:693-701.
Fleming P, Ferguson E, Townsend E, Lowe KC. Perceptions in transfusion medicine: a pilot field study on risk and ethics for blood and blood substitutes. Artif Cells Blood Substit Immobil Biotechnol. 2007;35:149-156.
Freilich D, Pearce LB, Pitman A, et al. R. HBOC-201 vasoactivity in a phase III clinical trial in orthopedic surgery subjects--extrapolation of potential risk for acute trauma trials. J Trauma. 66: 365-76, 2009.
Freilich D, Pearce LB, Pitman A, Greenburg G, Berzins M, Bebris L, Ahlers S, McCarron R. HBOC-201 vasoactivity in a phase III clinical trial in orthopedic surgery subjects--extrapolation of potential risk for acute trauma trials. J Trauma. 66: 365-76, 2009.
Freitag M, Mann O, Gottschalk A, Strate T, Standl T. Improvement of pancreatic tissue oxygenation by application of the bovine hemoglobin solution HBOC-301 with and without isovolemic hemodilution in swine with severe acute pancreatitis. Anesthesiology. 2004;101:A395.
Freitag M, Standl TG, Gottschalk A, Burmeister MA, Rempf C, Horn EP, Strate T, Schulte am Esch J. Enhanced central organ oxygenation after application of bovine cell-free hemoglobin HBOC-201. Can J Anesth 2005; 52(9): 904-914
Freitag M, Standl TG, Kleinhans H, Gottschalk A, Mann O, Rempf C, Bachman K, Gocht A, Petri S, Izbicki JR, Strate T. Improvement of impaired microcirculation and tissue oxygenation by Hemodilution with hydroxyethyl starch plus cell-free hemoglobin in acute porcine pancreatitis. Pancreatology. 2006;6:232-239.
Gardner RB, Hart KA, Stokol T, Divers TJ, Flaminio MJBF. Fell poly syndrome in a pony in North America. J Vet Intern Med. 2006;20:198-203.
Gasthuys M, Alves S, Tabet J. N-terminal adducts of bovine hemoglobin with glutaraldehyde in a hemoglobin-based oxygen carrier. Analytical Chemistry. 2005;77(10):3372-3378.
Gasthuys M, Fenaille AS, Tabet JC. Simple identification of a cross-linked hemoglobin by tandem mass spectrometry in human serum. Anal Chem. 2004;76(22):6628-6634.
Gawryl MS, Hamilton RG. Absence of IgE antibody responses to multi-dose IV administration of bovine hemoglobin (Hemopure) in humans. J Allergy Clin Immunol. 2000;105:S34. Abstract.
Gawryl MS, Hamilton RG. Immunologic safety studies of bovine-derived human blood substitute (Hemopure). J Allergy Clin Immunol. 2003;111(2 Suppl):S166. Abstract.
Gawryl MS, Rentko VT, Moon-Massat PF, Pearce LB. Toxicological effects associated with a bovine hemoglobin based oxygen carrier (HBOC-201) for treatment of hypovolemia. Shock. 2003;19(Suppl) A252.Abstract.
George I, Yi GH, Schulman, AR, Cheng Y, Gu A, Zhang G, Oz MC, Burkhoff D, Wang J. A polymerized bovine hemoglobin oxygen carrier preserves regional myocardial function and reduces infarct size after acute myocardial ischemia. Am J Physiol Heart Circ Physiol. 2006;291(3):H1126-H1137.
Gold JR, Divers TJ, deLahunta. Postanesthetic poliomyelopathy in a 7-day-old calf. J Vet Intern Med2005;19:775-778.
Goldberg R, Patino R, Brenner M, Lee J, Mahon S, Mukai D, Kreuter K, Tombert B, Saltzman D. Non-invasive in vivo monitoring of tissue hemoglobin after hemoglobin-based blood substitute infusion in rabbit hypovolemic shock. Crit Care Med 2007 Vol. 35, No. 12 (Suppl) #718
Gonzalez P, Hackney AC, Jones S, Strayhorn D, Hoffman EB, Hughes G, Jacobs EE, Orringer EP. A phase I/II study of polymerized bovine hemoglobin in adult patients with sickle cell disease not in crisis at the time of study. J Investig Med. 1997;45(5):258-264.
Gotshall RW, Hamilton KL, Foreman B, et al. Glutaraldehyde-polymerized bovine hemoglobin and phosphodiesterase-5 inhibition. Crit Care Med. 37:1988-93, 2009.
Guan F, Uboh C, Soma, L, et al. Unique tryptic peptides specific for bovine and human hemoglobin in the detection and confirmation of hemoglobin-based oxygen carriers. Anal Chem. 2004;76(17):5118-5126.
Guan F, Uboh CE, Soma LR, et al. Confirmation and quantification of hemoglobin-based oxygen carriers in equine and human plasma by hyphenated liquid chromatography tandem mass spectrometry. Anal Chem.2004;76(17):5127-5135.
Gurney J, Philbin N, Rice J, Arnaud F, Dong F, Wulster-Radcliffe M, Pearce LB, Kaplan L, McCarron R, Freilich D. A hemoglobin based oxygen carrier, bovine polymerized hemoglobin (HBOC-201) versus hetastarch (HEX) in an uncontrolled liver injury hemorrhagic shock swine model with delayed evacuation. J Trauma. 2004;57:726-738.
Hall C, Malkevich N, Handrigan, VanderMolen C, Aranaud F, Hong J, Dong F, Rice J, Philbin N, Ahlers S, McCarron R, Freilich D. Innate immune responses in swing resuscitated from severe traumatic hemorrhagiv shock with hemoglobin-based oxygen carrier-201. Art. Cell Blood Substit. Immobil. Biotech. 2007:35:259-274.
Hall RI. The utility of hemoglobin based oxygen carriers (HBOC) – can animal studies help? Can J Anaesth. 2005;52(9):895-898.
Hamilton RG, Kelly N, Gawryl MS, Rentko VT. Absence of immunopathology associated with repeated IV administration of bovine Hb-based oxygen carrier in dogs. Transfusion. 2001;41(2):219-225.
Handrigan MT, Bentley TB, Oliver JD, et al. Choice of fluid influences outcome in prolonged hypotensive resuscitation after hemorrhage in awake rats. Shock 2005; 23; 337-343
Hayward R, Lefer AM. Administration of polymerized bovine hemoglobin improves survival in a rat model of traumatic shock. Methods Find Exp Clin Pharmacol. 1999;21(6):427-433.
Henderson CL, Anderson MD, Sorrells DL, Wilson BJ, Dick EJ, DiGeronimo RJ. The use of a hemoglobin-based oxygen-carrying solution (HBOC-201) for extracorporeal membrane oxygenation in a porcine model with acute respiratory distress syndrome. Pediatr Crit Care Med. 2004;5(4):384-390.
Heneka MT, Loschmann PA, Osswald H. Polymerized hemoglobin restores cardiovascular and kidney function in endotoxin-induced shock in the rat. J Clin Invest. 1997;99(1):47-54.
Hohenhaus AE, Rentko VT. Blood transfusions and blood substitutes. In: DiBartola SP, ed. Fluid Therapy in Small Animal Practice. 2nd ed. Philadelphia, Pa: WB Saunders; 2000:451-464.
Hohenhaus AE. Editorial: Oxyglobin: A transfusion solution. J Vet Intern Med. 2002;16:394-395.
Horn EP, Standl T, Wilhelm S, et al. Bovine hemoglobin HBOC-201 causes a reduction of the oxygen partial pressure in poststenotic skeletal muscle. Anaesthesist. 1998;47(2):116-123. Abstract (English). Article in German.
Horn EP, Standl T, Wilhelm S, Jacobs EE, Freitag U, Freitag M, Schulte am Esch J. Bovine hemoglobin increases skeletal muscle oxygenation during 95% artificial arterial stenosis. Surgery. 1997;121(4):411-418.
Hughes G, Jacobs E, Antal E, et al. Pharmacokinetics of a novel hemoglobin-based oxygen carrier in humans. Crit Care Med. 1995;23(1):A257. Oral Presentations: Pharmacology. Abstract.
Irwin DC, Foreman B, Morris K, White M, Sullivan T, Jacobs R, Monnet E, Hackett T, TissotvanPatot MC, Hamilton KL, Gotshall RW. Polymerized bovine hemoglobin decreases oxygen delivery during normoxia and acute hypoxia in the rat. Am J Physiol Heart Circ Physiol. 295:H1090-H1099, 2008.
Jacobs EE, Gawryl MS. Tissue oxygen effects of HBOC-201 versus red blood cells. Progress in Applied Microcirculation: Microcirculatory Effects of Hemoglobin Solutions (Book). 2004;Volume 25,pp 16-26, Edited by K. Messmer, K.E. Burhop, J. Hunter. Basel, Karger.
Jacobs EE, Gawryl MS. Use of Hemoglobin Based Oxygen Carrier-201 when blood is not available or not acceptable. Transfusion. 2000;40(S152):41S.
Jahr JS, Liu H, Gull A, Maollempour M, Lim J, Gosselin R. Does HBOC-201 (Hemopure® ) affect platelet function in orthopedic surgery: a single site analysis. Anesth Analg. 2008;106:S-1-S-244. Abstract.
Jahr JS, Lurie F, Bezdikian V, Driessen B, Gunther RA. Measuring Circulating Blood Volume Using Infused Hemoglobin-Based Oxygen Carrier (Oxyglobin®) as an Indicator: Verification in a Canine Hypovolemia Model. Am J Ther. 2008 March/April;15(2):98-101.
Jahr JS, Lurie F, Bezdikian V, et al. Measuring Circulating Blood Volume Using Infused Hemoglobin-Based Oxygen Carrier (Oxyglobin® ) as an Indicator: Verification in a Canine Hypovolemia Model. Am J Ther. 2008 March/April;15(2):98-101.
Jahr JS, Lurie F, Driessen B, et al. The HemoCue, a point of care B-hemoglobin photometer, measures hemoglobin concentrations accurately when mixed in vitro with canine plasma and three hemoglobin-based oxygen carriers (HBOC). Can J Anaesth. 2002 Mar;49(3):243-8.
Jahr JS, Lurie F, Driessen B, Gunther RA, Golkaryeh MS. Comparing arterial oxygen saturation (SaO2) from a Nellcor Oxygen Saturation Monitor, IL Co-Oximeter and (LEXO2CON) with varying concentrations of Hemoglobin-Based Oxygen Carrier (HBOC) in a dog hemorrhage model. American Society of Anesthesiology. 2001;95:A557. Abstract.
Jahr JS, Lurie F, Driessen B, Tang Z, et al. Validation of oxygen saturation measurements in a canine model of hemoglobin based oxygen carrier (HBOC) infusion. Clin Lab Sci. 2000;13(3):173-178.
Jahr JS, Lurie F, Xi S, et al. A novel approach to measuring circulating blood volume: the use of a hemoglobin-based oxygen carrier in a rabbit model. Anesth Analg. 2001 Mar;92(3):609-614.
Jahr JS, Mackenzie C, Pearce LB, et al. HBOC-201 as an alternative to blood transfusion: efficacy and safety evaluation in a multicenter phase III trial in elective orthopedic surgery. J Trauma. 2008 Jun;64(6):1484-97
Jahr JS, Moallempour M, Lim JC. HBOC-201, hemoglobin glutamer-250 (bovine), Hemopure (Biopure Corporation). Expert Opin Biol Ther. 2008 Sep;8(9):1425-33. Review.
Jahr JS, Osgood S, Rothenberg SJ, et al.. Lactate measurement interface by hemoglobin-based oxygen carriers (Oxyglobin, Hemopure and Hemolink). Anesth Analg. 2005;100(2):431-436.
Jahr JS, Stewart LM, Mackenzie C, et al. Pivotal phase III study: safety of polymerized bovine hemoglobin (HBOC-201, Hemopure® ) as compared to RBC in patients undergoing orthopedic surgery. Anesthesiology. 2002;96:A243. Abstract.
Jahr JS, Walker V, Manoochehri K. Blood substitutes as pharmacotherapies in clinical practice. Curr Opin Anaesthesiol. 2007;20:325-330.
Jahr JS; Weeks DL; Desai P; Lim JC; Butch AW; Gunther R; Driessen B. Does OxyVita, a new generation hemoglobin-based oxygen carrier, or Oxyglobin acutely interfere with coagulation compared with normal saline or 6% hetastarch? An ex vivo thromboelastography study. J Cardiothorac Vasc Anesth. 2008;22(1):34-39.
Johnson T, Arnaud F, Dong F, et al. Bovine polymerized hemoglobin (hemoglobin-based oxygen carrier-201) resuscitation in three swine models of hemorrhagic shock with militarily relevant delayed evacuation - effects on histopathology and organ function. Crit Care Med. 2006;34(5):1464-1474.
Kahn AK, Jahr JS, Nesargi S, et al. Does lead interfere with hemoglobin-based oxygen carrier (HBOC) function? A pilot study of lead concentrations in three approved or tested HBOCs and oxyhemoglobin dissociation with HBOCs and/or bovine blood with varying lead concentrations. Anesth Analg. 2003;96:1813-20.
Kaplan LJ, Philbin N, Arnaud F, Rice J, Dong F, Freilich D. Resuscitation from hemorrhagic shock; fluid selectin and infusion strategy drives unmeasured ion genesis. J Trauma, Injury, Infection and Critical Care. 2006;61:90-98.
Kim HW, Hai CM, Greenburg AG. Artif Cells Blood Substit Immobil Biotechnol. 2010 Jan 5. [Epub ahead of print] Relative Roles of Heme-Irons and Globin-Thiols in the Genesis of Acellular Hemoglobin Mediated Vasoconstriction.
Kim HW. Effect of IV HBOC-201 on coronary hemodynamics and function in patients undergoing elective PCI. XIth International Symposium on Blood Substitutes. Beijing, China - October 20, 2007.
King DR, Cohn S, Proctor K. Resuscitation with a hemoglobin-based oxygen carrier after severe brain trauma. Journal of the American College of Surgeons. 2004;199(3 Suppl):45.
King DR, Cohn SM, Proctor KG. Resuscitation with a hemoglobin-based oxygen carrier after traumatic brain injury. J Trauma, Injury, Infection and Critical Care. 2005;59(3):553-562.
Kleinhans H, Mann O, Schurr PG, Kaifi JT, Hansen B, Izbicki JR, Strate T. Oxygen radical formation does not have an impact in the treatment of severe acute experimental pancreatitis using free cellular hemoglobin. World J Gastroenterol. 2006 May 14; 12(18): 2914-2918.
Knudson MM, Lee S, Erickson V, Morabito D, Derugin N, Manley GT. Tissue oxygen monitoring during Hemorrhagic shock and resuscitation: A comparison of lactated ringer's solution, hypertonic saline dextran and HBOC-201. J Trauma, Injury, Infection and Critical Care. 2003;54:242-52.
Koch T, Duncker HP, Heller A, Schaible R, Van Ackern K, Neuhof H. Effects of stroma-free hemoglobin solutions on pulmonary vascular resistance and mediator release in the isolated perfused rabbit lung. Shock. 1994;1(2):146-152.
Kubulus D, Rensing H, Paxian M,et al. Influence of heme-based solutions on stress protein expression and organ failure after hemorrhagic shock. Crit Care Med. 2005;33:629-637.
Kunicka J, Malin M, Zelmanovic D, et al. Automated Quantitation of Hemoglobin-Based Blood Substitutes in Whole Blood Samples. Am JClin Pathol 2001;116:913-919.
Laccetti A, Baqai J, Gawryl MS, Light WR. Hemopure's process demonstrates TSE and viral clearance. Vyas GN, Williams AE (eds.) Advances in Transfusion Safety. Dev Biol (Basel), Karger. 2005;120:35-36.
LaMuraglia GM, O'Hara PJ, Baker WH, Naslund TC, Norris EJ, Li J, Vandermeersch E. The reduction of the allogenic transfusion requirement in aortic surgery with hemoglobin-based solution. J Vasc Surg. 2000;31(2):299-308.
Lasne F, Crepin N, Ashenden M, et al. J. Detection of hemoglobin-based oxygen carriers in human serum for doping analysis: screening by electrophoresis. Clin Chem. 2004;50(2):410-415.
Lee SK, Morabito D, Hemphill JC, Erickson V, Holcroft JJ, Derugin N, Knudson MM, Manley GT. Small-volume resuscitation with HBOC-201: Effects on cardiovascular parameters and brain tissue oxygen tension in an out-of-hospital model of hemorrhage in swine. Acad Emerg Med. 2002;9(10);969-976.
Levien LJ. Bovine hemoglobin (Hemopure): Clinical Use in South Africa. Accepted for oral presentation at the Xth International Symposium on Blood Substitutes, Brown University, Providence, RI, June 14, 2005, abstract.
Levien LJ. Clinical Use of Hemopure (HBOC 201) in South Africa. Presented at the Annual Meeting of the Vascular Society of Southern Africa. Stellenbosch, South Africa. October 2003 Abstract.
Levien LJ. Clinical Use of Hemopure (HBOC 201) in South Africa. Presented at the Controversies and Problems in Surgery IX Symposium. University of Pretoria, South Africa. October 2003 Abstract.
Levien LJ. South Africa: clinical experience with Hemopure. ISBT Science Series.2006;1:167-173.
Levy J. The use of haemoglobin glutamer-250 (HBOC-201) as an oxygen bridge in patients with acute anaemia associated with surgical blood loss. Expert Opin Biol Ther. 2003;3(3):509-517.
Levy JH, Goodnough LT, Greilich P, Pet al. A room-temperature stable hemoglobin (HBOC-201) eliminates allogeneic red blood cell (RBC) transfusion in post-operative cardiac surgery patients. Circulation. 1998;17(Suppl 1):132. Abstract.
Levy JH, Goodnough LT, Greilich PE, et al. Polymerized bovine hemoglobin solution as a replacement for allogeneic red blood cell transfusion after cardiac surgery: Results of a randomized, double-blind trial. J Thorac Cardiovasc Surg. 2002;124(1):35-42.
Lichtenberger, M. Transfusion medicine in exotic pets. Clinical Techniques in Small Animal Practice. 2004;19(2):88-95.
Light WR, Jacobs EE, Rentko VT, Gawryl MS, Hughes GS. Use of HBOC-201 as an oxygen therapeutic in the preclinical and clinical settings. In: Rudolph AS, Rabinovici R, Feuerstein GZ, eds. Red Blood Cell Substitutes: Basic Principles and Clinical Applications. Marcel Dekker Inc; 1998:19:421-36.
Lipfert B, Standl T, Dullmann J, et al. Histology and ultrastructure of liver and kidney following blood exchange with ultrapurified, polymerised bovine hemoglobin in comparison with hydroxyethyl starch. Lab Invest. 1999;79(5):573-582.
Loke KR, Forfia PR, Recchia FA, et al. Bovine polymerized hemoglobin increases cardiac oxygen consumption and alters myocardial substrate metabolism in conscious dogs: role of nitric oxide. J Cardiovasc Pharmacol. 2000;35:84-92.
Lurie F, Driessen B, Jahr JS, et al. Validity of arterial and mixed venous oxygen saturation measurements in a canine hemorrhage model after resuscitation with varying concentrations of hemoglobin-based oxygen carrier. Anesth Analg. 2003;96:46-50. Abstract.
Lurie F, Jahr JS, Davis JM, Uet al. Reliability of plasma hemoglobin concentrations measurement using the HemoCue®, a point of care hemoglobin photometer, after infusions of hemoglobin-based oxygen carrier (HBOC). Anesthesiology. 2000;93:A408.
Lurie F, Jahr JS, Driessen B, et al. Mixed venous oxygen saturation (SvO2) measured with an Abbot Oximetric pulmonary artery catheter, and instrumentation laboratory co-Oximeter after resuscitation with varying concentrations of Hemoglobin-Based Oxygen Carrier (HBOC) in a dog hemorrhage model. American Society of Anesthesiology. 2001. Abstract.
Lurie F, Jahr JS, Driessen B, Tang Z, Louie R. Oxygen saturation measurements in canine blood after hemoglobin glutamer-200 (bovine) (HBOC) infusion: In vitro validation of the Nova Co-Oximeter. Anesthesiology. 2000;93:A407.
Lurie F, Jahr JS, Driessen B. The novel HemoCu plasma/low hemoglobin system accurately measures small concentrations of three different hemoglobin-based oxygen carriers in plasma: hemoglobin glutamer-200 (bovine) (Oxyglobin), hemoglobin glutamer-250 (bovine) (Hemopure), and hemoglobin-Raffimer (Hemolink). Anesth Analg. 2002 Oct;95(4):870-3, table of contents.
Lurie F, Jahr JS, Driessen B. Validation of Hemocue plasma/low hemoglobin system for measurements of low concentration plasma hemoglobin after hemoglobin-based oxygen carrier (HBOC) transfusion. American Society of Anesthesiology. 2001;95:A558. Abstract.
Mackenzie CF, Bucci C. Artificial oxygen carriers for trauma: myth or reality? Hospital Medicine, October 2004; Vol 65, No 10:582-588.
Mackenzie CF. Haemoglobin-based oxygen carriers: is the benefit worth the risk? Br J Hosp Med (Lond). 2009 Jan;70(1):26-30.
Manley G, Morabito D, Hemphill J, Erickson V, Holcraft J, Derugin N, Knudson MM. Effect of small-volume resuscitation with hemoglobin substitute HBOC-201 on brain tissue oxygenation following experimental hemorrhagic shock. J Trauma. 2000;48(1):195. Abstract.
Manley GT, Hemphill C, Morabito D, Erickson V, Holcroft JJ, Derugin N, Knudson MM. Small-volume resuscitation with the hemoglobin substitute HBOC-201: Effect on brain tissue oxygenation. Oxygen Transport to Tissue XXIV. Eds. Dunn and Schwartz, KluwerAcademia / Plenum Publishers. 2003;29:311-317.
Manley GT, Rosenthal G, Lam M, Morabito D, Yan D, Derugin N, Bollen A, Knudson MM, Panter SS. Controlled cortical impact in swine: pathophysiology and biomechanics. J Neurotrauma. 2006;23(2):128-139.
Manning JE, Katz LM, Brownstein MR, Pearce LB, Gawryl MS, Baker CC, Carolina Resuscitation Group. Bovine hemoglobin-based oxygen carrier (HBOC-201) for resuscitation of uncontrolled, exsanguinating liver injury in swine. Shock. 2000;13(2):152-159.
Manning JE, Katz LM, Pearce LB, Batson N, McCurdy SL, Gawryl MS, Baker CC. Selective aortic arch perfusion with hemoglobin-based oxygen carrier-201 for resuscitation from exsanguinating cardiac arrest in swine. Crit Care Med. 2001;29(11): 2067-2074.
March H, Barger A, McCullough S, Schaeffer D, MacWilliams P. Use of the ADVIA 120 for differentiating extracellular and intracellular hemoglobin. Veterinary Clinical Pathology. 2005;34(2):106-109.
Marret E, Riou B, Jacobs E, Coriat P, Samama CM. Bovine haemoglobin solution and gelatin infusion in a rabbit model of arterial thrombosis and bleeding. Eur J Anaesth. 2000;17(19):A-234. Abstract.
Maxwell RA, Gibson JB, Fabian TC, Proctor KG. Resuscitation of Severe Chest Trauma with Four Different Hemoglobin-Based Oxygen-Carrying Solutions. J Trauma. 2000;49:200-211. Abstract. (Note: HBOC formulation may have been modified.)
McNeil JD, Smith DL, Josephs JJ. Hypotensive resuscitation using a polymerized bovine hemoglobin based oxygen carrying solution (HBOC-201) leads to reversal of anaerobic metabolism. J Trauma. 2001;50(6):1063-1075.
Meliga E, Vranckx P, Regar E, et al. Proof-of-concept trial to evaluate haemoglobin based oxygen therapeutics in elective Percutaneous coronary revascularization. Rationale, protocol design and haemodynamic results. EuroInterv 2008;4:99-107.
Moallempour M, Jahr JS, Lim JC, Weeks D, Butch A, Driessen B. Methemoglobin effects on coagulation: a dose-response study with HBOC-200 (Oxyglobin) in a thrombelastogram model. J Cardiothorac Vasc Anesth. 2009 Feb;23(1):41-7.
Mongan PD, Moon-Massat PF, Rentko V, Mihok S, Dragovich A, Sharma P. Regional blood flow after serial normovolemic exchange transfusion with HBOC-201 (Hemopure) in anesthetized swine. J Trauma. 67:51-60, 2009.
Moon PF, Bliss SP, Posner LP, Erb HN, Nathanielsz PW. Fetal oxygen content is restored after maternal hemorrhage and fluid replacement with polymerized bovine hemoglobin, but not with hetastarch, in pregnant sheep. Anesth Analg. 2001;93:142-150.
Moon PF, Rentko VT, Pearce LB, Gawryl MS. Effect of HBOC polymerization on clinical signs, clinical chemistry, and histopathology. Shock. 2003;19(Suppl) A253. Abstract.
Moon-Massat PF, Tierney JP, Hock KG, et al. Hitachi Hemolytic Index correlates with HBOC-201 concentrations: impact on suppression of analyte results. Clinical Biochemistry. 2008;41:432-435.
Muir WW, Wellman ML. Hemoglobin solutions and tissue oxygenation. J Vet Intern Med. 2003;17:127-135.
Mullon J, Giacoppe G, Clagett C, McCune D, Dillard T. Transfusions of polymerized bovine hemoglobin in a patient with severe autoimmune hemolytic anemia. New Engl J Med. 2000;342(22):1638-1643.
Nascimento P, Vaid S, Hoskins S, Espana J, Kinsky M, Deyo D, Kramer G. Comparison of plasma volume expansion measured by Indocy Anine Green (ICG) or hematocrit in hemorrhaged resuscitated swine. Shock. 2005;23:28-29 (Abstract).
Neragi-Mandoab S, Vlahakes GJ. Elevated troponin I level with hemoglobin based oxygen carrying solutions (HBOCs) as a priming solution despite improved left ventricular function. Interactive Cardiovascular and Thoracic Surgery. 2006;5:135-138.
Neragi-Miandoab S, Guerrero JL, Vlahakes GJ. Autologous blood sequestration using a double venous reservoir bypass circuit and polymerized hemoglobin prime. ASAIO Journal. 2002;48:407-411
Ness PM, Cushing MM. Oxygen Therapeutics Pursuit of an Alternative to the Donor Red Blood Cell Arch Pathol Lab Med. 2007;131:734-741.
Neya K, Lee R, Vlahakes GJ. Hemoglobin based oxygen carrying solution stability in extracorporeal circulation: an in vitro evaluation and implication for clinical use. ASAIO J. 1998;(44)3:166-170.
Niquille M, Touzet M, Leblanc I, Baron JF. Reversal of intraoperative myocardial ischemia with a hemoglobin-based oxygen carrier. Anesthesiology. 2000;92(3):882-885.
Orcutt C. Oxyglobin® administration for the treatment of anemia in ferrets. In: Exotic DVM. 2000;2(3):44-46. Abstract.
Ortegon DP, Davis MR, Sampson JB, et al.. Bovine hemoglobin-based oxygen carrying solution (HBOC-201) improves flap survival in a rat model of epigastric flap failure. Microsurgery. 2006;26:203-206.
Ortegon DP, Dixon PS, Crow KK, Mueller DL, Kerby JD. The effect of the bovine hemoglobin oxygen therapeutic HBOC-201 on human neutrophil activation in vitro. J Trauma, Injury, Infection and Critical Care. 2003;55(4):755-61.
Osgood Sl, Jahr JS, Desai P et al. Does methemoglobin from oxidized hemoglobin –based oxygen carrier (Hemoglobin Glutamer-200) interfere with lactate measurement (YS1 2700 SELECT Biochemistry Analyzer)? Anesth Anelg. 2005; 100:437-439.
Patel MB, Feinstein AJ, Saenz AD, Majetschak M, Proctor KG. Prehospital HBOC-201 after traumatic brain injury and hemorrhagic shock in swine. J Trauma, Injury, Infection and Critical Care. 2006;61(1):46-56.
Pearce BJ, Gawryl MS. The pharmacology of tissue oxygenation by Biopure's hemoglobin-based oxygen carrier, Hemopure (HBOC-201). Adv Exp Med Biol. 2003;530:261-270.
Pearce LB, Gawryl MS, Rentko VT, Moon-Massat PF, Rausch CW. HBOC-201 [Hemoglobin Glutamer-250 (bovine), Hemopure]: clinical studies. In: .Winslow R. (ed) Blood Substitutes. London, England: Elsevier Inc;:2006:437-450.
Pearce LB, Gawryl MS. Overview of preclinical and clinical efficacy of Biopure's HBOCs. In: Chang TMS, ed. Blood Substitutes: Principles, Methods, Products and Clinical Trials. New York: Karger Langer Systems; 1998;5:82-100.
Pearce LB, Pitman A, Greenburg AG, Freilich DA, Kaplan L. Application of a unique scoring system for numerical determination of a benefit risk ratio in clinical trials. Clinical Pharmacology & Therapeutics. 2008;83(Suppl 1):S87-88;PIII-52. Abstract.
Pearce LB, Pitman AN, Connolly M. Risk of adverse outcome due to acute anemia in the orthopedic surgical setting. Clinical Pharmacology & Therapeutics. 2008;83(Suppl 1):S39;OII-B-4. Abstract.
Pearce LB, Pitman AN, Greenburg AG. Breaking the rules: misinterpretation of dose-response relationships in clinical trials. Clinical Pharmacology & Therapeutics. 2008;83(Suppl 1):S87;PIII-50. Abstract.
Pearce LB, Rentko VT, Moon-Massat PF, et al.. Comparative pharmacokinetics of a hemoglobin-based oxygen carrier. Acad Emerg Med. 2003; Volume 10, Number 5:557.
Pearce LB, Rentko VT, Moon-Massat PF, et al.. The pharmacokinetics of a hemoglobin-based oxygen carrier, HBOC-201, does not change during second trimester pregnancy. Acad Emerg Med. 2003; Volume 10, Number 5:494.
Perkins GA, Divers TJ. Polymerized hemoglobin therapy in a foal with neonatal isoerythrolysis. J Vet Emerg Crit Care. 2001;11(2):141-146.
Philbin N, Rice J, Gurney J, McGwin G, Arnaud F, Dong F, Johnson T, Flournoy WS, Ahlers S, Pearce LB, McCarron R, Freilich D. A hemoglobin-based oxygen carrier, bovine polymerized hemoglobin (HBOC-201) versus hetastarch (HEX) in a moderate severity hemorrhagic shock swine model with delayed evacuation. Resuscitation. 2005;66:367-378
Pitman AN, Pearce LB. A flexible outcome scoring system for clinical trials. Clinical Pharmacology & Therapeutics. 2008;83(Suppl 1):S87PIII-51. Abstract.
Posner LP, Moon PF, Bliss SP, Gleed RD, Erb HN. Colloid osmotic pressure after hemorrhage and replenishment with Oxyglobin Solution, hetastarch, or whole blood in pregnant sheep. Veterinary Anaesthesia. 2003;30:30-36.
Raabe A, Gottschalk A, Hommel M, Dubben H, Strandl T. No effect if the hemoglobin solution HBOC-201 on the response of the rat R1H tumor to fractionated irradiation. Strahlenther Onkol 2005; 11: 730-737
Rempf C, Standl T, Schenke K, Chammas K, Gottschalk A, Burmeister MA, Gottschalk A. Administration of bovine polymerized haemoglobin before and during coronary occlusion reduces infarct size in rabbits. Br J Anaesth. 103: 470-1, 2009.
Rentko VT, Cotter SM. Hematopoietic Dysfunction. In: Slatter D, eds. Textbook of Small Animal Surgery. 3rd Ed. Philadelphia , Pa: WB Saunders; 2003;68:1030-1037.
Rentko VT, Pearce LB, Moon-Massat PF, Gawryl MS. Hemopure [HBOC-201, Hemoglobin Glutamer-250 (Bovine)]: Preclinical Studies. Blood Substitutes. In.: Winslow RM, ed. London, UK: Elsevier Inc.; 2006:424-436.
Rentko VT, Sharpe TA. Red blood cell substitutes. In: Feldman BF, Zinkl JG, Jain NC, eds. Schalm's Veterinary Hematology. 5th ed. Philadelphia, Pa: Lippincott Williams & Wilkins; 2000:874-878.
Rentko VT. Practical use of a blood substitute. In: Bonagura JD, ed. Kirk's Current Veterinary Therapy. Philadelphia, Pa: WB Saunders; 2000:424-427.
Rentko, VT, Pearce LB, Moon-Massat PF, Hansen BJ, Gawryl MS. Pharmacokinetics of low doses of a hemoglobin-based O2 carrier in dogs with normovolemic anemia. JVIM. 2003;17(3):407(A114) Abstract.
Rice J, Philbin N, Arnaud F, McCarron R, Freilich D, Stern S, McGwin G. Resuscitation with HBOC-201 vs. LR following severe uncontrolled hemorrhage and traumatic brain injury (TBI) in swine. Crit Care Med. 2005;33(12):A31.
Rice J, Philbin N, Handrigan M, Hall C, McGwin G, Ahlers S, Pearce L B, Arnaud F, McCarron R, Freilich D. Vasoactivity of bovine polymerized hemoglobin (HBOC-201) in swine with traumatic hemorrhagic shock with and without brain injury. J Trauma. 2006; 61(5): 1085-1099.
Rice J, Philbin N, Light R, et al. The effects of decreasing low-molecular weight hemoglobin components of hemoglobin-based oxygen carriers in swine with hemorrhagic shock. J Trauma. 2008 May;64(5):1240-57.
Rivera F, Minei JP. Hypertonic HBOC-201 resuscitation decrease endothelin levels after hemorrhagic shock. Journal of Surgical Research. 2006;130(2):281. (Abstract #327)
Rivera-Chavez FA, Brown RJ, Minei JP. Hypertonic HBOC-201 reduces the systemic and pulmonary hypertension observed with standard HBOC-201. American Association for the Surgery of Trauma (AAST). Presented at the 2005 Annual Meeting of the American Association for the Surgery of Trauma, Atlanta, GA. September 22-24, 2005.
Rivera-Chavez FA, Huerta S, Brown R, York GB, Minei JP. Resuscitation from hemorrhagic shock comparing standard hemoglobin-based oxygen carrier (HBOC)-201 versus 7.5% hypertonic HBOC-201. J Trauma, Injury, Infection and Critical Care. 2007;63(5):1113-1119.
Rivera-Chavez FA, York GB, Brown R, Minei JP. Hypertonic HBOC-201 limits neutrophil activation after hemorrhagic shock. Eastern Association for the Surgery of Trauma (EAST). Presented at the 19th Annual Scientific Meeting of East, Orlando, FL. January 10-14, 2006.
Rosenthal G, Cohen M, Morabito D, Derugin N, Panter S, Knudson MP, Manley GT. HBOC-201 improves resuscitation parameters and prevents secondary brain injury in a swine model of traumatic brain injury and hemorrhage. Presented at the 74th AANS (American Association of Neurological Surgeons) Annual Meeting, 25 April 2006, San Francisco, CA.
Rosenthal G, Morabito D, Cohen M, Roeytenberg A, Derugin N, Panter SS, Knudson MM, Manley G. Use of hemoglobin-based oxygen-carrying solution-201 to improve resuscitation parameters and prevent secondary brain injury in a swine model of traumatic brain injury and hemorrhage. J Neurosurg. 2008 Mar;108(3):575-87.
Sampson JB, Davis MR, Mueller DL, Kashyap VS, Jenkins DH, Kerby JD. A Comparison of the Hemoglobin-Based Oxygen Carrier HBOC-201 to Other Low-Volume Resuscitation Fluids in a Model of Controlled Hemorrhagic Shock. J Trauma. 2003;55(4):747-54.
Serruys PW, Vranckx P, Slagboom T, Regar E, Meliga E, de Winter RJ, Heyndrickx G, Schuler G, van Remortel EA, Dube GP, Symons J. Haemodynamic effects, safety and tolerability of haemoglobin-based oxygen carrier-201 in patients undergoing PCI for CAD. EuroInterv. 2008;3:600-609.
Soma LR, Uboh CE, Guan F, Luo Y, Moate PJ, Boston RC, Driessen B. The pharmacokinetics of hemoglobin-based oxygen carrier hemoglobin glutamer-200 bovine in the horse. Anesth Analg. 2005;100:570-1575.
Spahn DR, Kocian R. Artificial O2 carriers: status in 2005. Current Pharmaceutical Design. 2005;11:4099-4114.
Sprung J, Kindscher JD, Wahr JA, Levy JH, Monk TG, Moritz MW, O'Hara PJ. The use of bovine hemoglobin glutamer-250 (Hemopure®) in surgical patients: results of a multicenter, randomized, single-blinded trial. Anesth Analg. 2002;94(4):799-808.
Sprung J, Kindscher JD, Wahr JA, Levy JH, Monk TG. Plasma hemoglobin and methemoglobin concentrations after infusion of bovine hemoglobin-based oxygen carrier (HBOC) in surgical patients. American Society of Anesthesiologists. 2001;95:A394. Abstract.
Stefan DC, Uys R, Wessels G. Hemopure transfusion in a child with severe anemia. Pediatric Hematology and Oncology. 2007;24:269-273.
Stern S, Rice J, Philbin N, et al. Resuscitation with the hemoglobin-based oxygen carrier, HBOC-201, in a swine model of severe uncontrolled hemorrhage and traumatic brain injury. Shock. 2009 Jan;31(1):64-79.
Stollings JL, Oyen LJ. Oxygen Therapeutics: Oxygen Delivery without Blood. Pharmacotherapy. 2006;26(10):1453-1464.
Strange MB, Caswell JE, Jones SP, Cole PA, Dale PJ, Lefer DJ. Evaluation of a hemoglobin based blood substitute in a canine model of myocardial ischemia-reperfusion. FASEB J. 2000;14(4):A467. Abstract.
Strate T, Freitag M, Kleinhans H, Mann O, Schneider C, Yekeban E, Bloechle C, Standl T, Knoefe WTl, Izbicki JR. Isovolemic hemodilution with HES and bovine hemoglobin improves pancreatic microcirculation, tissue oxygenation and survival in a porcine model of severe acute pancreatitis. Pancreas. 2003;27(4):413.
Strate T, Mann O, Kleinhans H, Rusani S, Schneider C, Yekebas E, Freitag M, Standl T, Bloechle C, Izbicki JR. Microcirculatory function and tissue damage is improved after therapeutic injection of bovine hemoglobin in severe acute rodent pancreatitis. Pancreas. 2005 Apr;30(3):254-9.
Strate T, Mann O, Kleinhans H, Schneider C, Knoefel WT, Yekebas E, Standl T, Bloechle C, Izbicki JR. Systemic intravenous infusion of bovine hemoglobin significantly reduces microcirculatory dysfunction in experimentally induced pancreatitis in the rat. Annals of Surgery. 2003;238(5):765-71.
Sun PZ, Schoening ZB, Jasanoff A. In vivo oxygen detection using exogenous hemoglobin as a contrast agent in magnetic resonance microscopy. Magnetic Resonance in Medicine. 003;49:609-614.
te Lintel Hekkert M, Dubé GP, de Boer M, et al. Intracoronary infusion of oxygenated haemoglobin-based oxygen carrier, HBOC-201, during brief coronary artery occlusion in pigs provides cardioprotection. Acta Physiological Sinica, 60: 301-418, 2008.
The effect of Hemopure on coagulation in clinically relevant concentrations. Anesth Analg. 2004;99:1593-1597.
The effects of a polymerized bovine-derived hemoglobin solution in a rabbit model of arterial thrombosis and bleeding. Anesth Analg. 2004;98:604-610.
Thevis M, Ogorzalek Loo RR, Loo J, Schanzer W. Doping control analysis of bovine hemoglobin-based oxygen therapeutics in human plasma by LC-electroscopy ionization-MS/MS. Anal Chem. 2003;75(14):3287-3293.
Tsai AG, Cabrales P. Can the effects of vasoactivity of molecular hemoglobin-based plasma expanders be ignored? Crit Care Med. 2006;34(5):1566-1567.
Umar RK, Katz LM, Manning JE, Pearce BL, Gawryl MS. Selective aortic arch perfusion of hemoglobin bovine oxygen carrier-201 during cardiac arrest decreases heart damage in dogs. Acad Emerg Med. 1999;6(5):508.
VanderMolen C, Malkevich N, Philbin N, et al.Immune effects of decreasing low-molecular weight hemoglobin components of hemoglobin-based oxygen carriers (HBOC) in a swine model of severe controlled hemorrhagic shock. Artif Cells Blood Substit Immobil Biotechnol. 2007;35(5):507-17
Varet-Marie E, Ashenden M, Lasne F, Sicart MT, Marion B, De Ceaurriz J, Audran M. Detection of hemoglobin-based oxygen carriers in human serum for doping analysis: Confirmation by size-exclusion HPLC. Clinical Chemistry. 2004;50(4):723-731.
Wang TY, Ra SV. Anemia in Patients Undergoing Percutaneous Coronary Intervention: Current Issues and Future Directions. Am J Cardiovasc Drugs. 2007;7(4):225-33.
Warndorf M, Dong F, Philbin NB, Rice JP, Arnaud FG, Pearce LB, McCarron RM, Frelich DA. ASAIO Journal. 2005;51(2):6A.
Weinkle TK, Center SA, Randolph JF, Warner KL, Barr SC. Evaluation of prognostic factors, survival rates, and treatment protocols for immune-mediated hemolytic anemia in dogs: 151 cases (1993-2002) JAVMA. 2005;226(11):1869-1880
Wettstein R, Tsai AG, Harder Y, Erni D, Intaglietta M. Early resuscitation with polymerized bovine hemoglobin reverses acidosis, but not peripheral tissue oxygenation, in a severe hamster shock model. Shock. 2006 Nov;26(5):496-503.
Wolthuis A, Peek sD, Scholten R, Moreira P, Gawryl MS, Clark T, Westerhuis L. Effect of the hemoglobin-based oxygen carrier HBOC-201 on laboratory instrumentation: Cobas Integra, Chiron Blood Gas Analyzer 840, Sysmex SE-9000 and BCT. Clin Chem Lab Med. 1999;37(1):71-76.
Wu. J, Hutchings A, Rodriguez C, He J, Moon-Massat P, Rue L III, Kerby J. HBOC may attenuate inflammation by constraining the late-acting inflammatory protein Hmgb-1 in an acute hemorrhage model. XIth International Symposium on Blood Substitutes Beijing, China - October 20, 2007
York GB, DiGeronimo R, Wilson BJ, Cofer BR, Breuer CK,Josephs JD, Smith DL, Sorells DP. Extracorporeal membrane oxygenation in piglets using a polymerized bovine hemoglobin-based oxygen-carrying solution (HBOC-201). J Pediatr Surg. 2002;37(10):1387-1392.
York GB, Eggers JS, Smith DL, Jenkins DH, McNeil JD, Mueller D, Josephs JD, Kerby JD. Low-volume resuscitation with a polymerized bovine hemoglobin-based oxygen-carrying solution (HBOC-201) provides adequate tissue oxygenation for survival in a porcine model of controlled hemorrhage. J Trauma, Injury, Infection and Critical Care. 2003;55(5):873-85.
Yu B, Raher MJ, Volpato GP, Bloch KD, Ichinose F, Zapol WM. Inhaled nitric oxide enables artificial blood transfusion without hypertension. Circulation. 2008;117:1982-1990.
Zambelli AB, Leisewitz AL, Schoeman JP. Oxyglobin and packed red cell transfusions provide similar blood gas, acid base, haemodynamic and subjective benefits in a canine Babesia Rossi model of anaemia. Presented at the 16th ECVIM-CA Congress, 14-16 September 2006, Amsterdam, The Netherlands.
Zambelli AB, Leisewitz AL. A prospective, randomized comparison of Oxyglobin (HB-200) and packed red blood cell transfusion for canine babesiosis. J Vet Emerg Crit Care. 19: 102-12, 2009.
HbO2 Therapeutics LLC - All Rights Reserved